Chemoprevention of triple negative breast cancer by targeting Wnt signaling.

• Project/Area Number: 17K10556
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: Ohtake Tohru 福島県立医科大学, 医学部, 教授 (50363750)
• Co-Investigator(Kenkyū-buntansha): 岡山 洋和 福島県立医科大学, 医学部, 講師 (20583397) ; 立花 和之進 福島県立医科大学, 医学部, 学内講師 (50583598) ; 齋藤 元伸 福島県立医科大学, 医学部, 講師 (90611749)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: トリプルネガティブ乳癌 / Wntシグナル / Wnt/β-cateninシグナル / 化学予防 / 乳癌

Outline of Final Research Achievements

This study was designed to analyze the association between triple negative breast cancer and Wnt signaling. This study revealed an association between triple negative breast cancer and Wnt signaling. Annexin A1 and AP1 were considered as Wnt signaling related molecules. Immunohistological, prognostic, and clinicopathological analysis in breast cancer cases revealed that triple negative breast cancer cases with high expression of annexin A1 were poor prognosis than those without expression. Analysis of AP1 expression patterns showed a significant correlation with breast cancer subtypes.

Academic Significance and Societal Importance of the Research Achievements

トリプルネガティブ乳癌とWntシグナルとの関連ならびにアネキシンA1発現、AP1発現との関連と臨床学的意義を研究することは、発癌機序や予後因子との関連の解明に必須であるとともに、乳癌の化学予防や個別化医療に寄与する可能性がある。

Research Products

• [Journal Article] Clinicopathological examination of dipeptidase 1 expression in colorectal cancer. (2017)
  • Author(s): Tachibana K, Saito M, Imai JI, Ito E, Yanagisawa Y, Honma R, Saito K, Ando J, Momma T, Ohki S, Ohtake T, Watanabe S, Waguri S, Takenoshita S
  • Journal Title: Biomedical Reports Volume: 6 Pages: 423428-423428
  • DOI: 10.3892/br.2017.870
  • Peer Reviewed / Open Access
• [Presentation] トリプルネガティブ乳癌におけるAnnexin A1の発現と臨床病理学的因子との関連および予後の検討 (2017)
  • Author(s): 立花和之進
  • Organizer: 第25回日本乳癌学会