Investigation of CCN family for development and drug resistance of gastrointestinal cancers
Project/Area Number |
17K10596
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Kumamoto University |
Principal Investigator |
Nagai Youhei 熊本大学, 病院, 特任助教 (30551254)
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Co-Investigator(Kenkyū-buntansha) |
石本 崇胤 熊本大学, 病院, 特任准教授 (00594889)
馬場 祥史 熊本大学, 病院, 非常勤診療医師 (20599708)
小澄 敬祐 熊本大学, 病院, 非常勤診療医師 (50594884)
吉田 直矢 熊本大学, 病院, 特任准教授 (60467983)
宮本 裕士 熊本大学, 病院, 講師 (80551259)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | CCN family / 消化器癌 / バイオマーカー / エピジェネティクス / がん代謝 / 腫瘍免疫 / genetic change / epigenetic change / cancer metabolism / immunity / microbiome / predictive marker |
Outline of Final Research Achievements |
The aim of the current study is to investigate the significance of CCN(Cyr61:cysteine-rich 61、CTGF:connective tissue growth factor、Nov:nephroblastoma overexpressed)family using global human population-based database, and contribute to the development of the new treatments. We found the significant inverse association of CCN4 expression level with high-T, high-M, high-Stage, poor clinical outcomes, and less follicle lymphocytic reaction. Our findings support the possible influence of CCN4 on cancer development and anti-tumor immunity.
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Academic Significance and Societal Importance of the Research Achievements |
本研究では間質増殖因子CCN(Cyr61:cysteine-rich 61、CTGF:connective tissue growth factor、Nov:nephroblastoma overexpressed)family の消化器癌における意義を明らかにすべく、グローバルかつ膨大な消化器癌データベースを用い、検討を行った。その結果、CCN familyの一つであるCCN4が食道癌の癌進展、予後不良に関連する可能性が示唆された。また、飲酒歴およびリンパ球浸潤低下と関連する可能性もあり、今後の発癌予防および免疫を介したがん治療に寄与できる可能性が示唆された。
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Prognostic Factors of Salvage Esophagectomy for Residual or Recurrent Esophageal Squamous Cell Carcinoma After Definitive Chemoradiotherapy.2018
Author(s)
Kiyozumi Y, Yoshida N, Ishimoto T, Yagi T, Koga Y, Uchihara T, Sawayama H, Hiyoshi Y, Iwatsuki M, Baba Y, Miyamoto Y, Watanabe M, Matsuyama T, Oya N, Baba H.
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Journal Title
World J Surg.
Volume: Feb 8.
Issue: 9
Pages: 2887-2893
DOI
Related Report
Peer Reviewed
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[Journal Article] Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen species.2018
Author(s)
Kitano Y, Baba Y, Nakagawa S, Miyake K, Iwatsuki M, Ishimoto T, Yamashita YI, Yoshida N, Watanabe M, Nakao M, Baba H.
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Journal Title
J Pathol.
Volume: 244(3)
Issue: 3
Pages: 346-357
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fusobacterium nucleatum in gastroenterological cancer: Evaluation of measurement methods using quantitative polymerase chain reaction and a literature review.2017
Author(s)
Yamamura K, Baba Y, Miyake K, Nakamura K, Shigaki H, Mima K, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, Yamashita Y, Yoshida N, Watanabe M, Baba H
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Journal Title
Oncol Lett
Volume: 14(6)
Pages: 6373-6378
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Colorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc.2017
Author(s)
Izumi D, Ishimoto T, Miyake K, Eto T, Arima K, Kiyozumi Y, Uchihara T, Kurashige J, Iwatsuki M, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Goel A, Tan P, Baba H.
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Journal Title
Stem Cells.
Volume: 35(9)
Issue: 9
Pages: 2027-2036
DOI
Related Report
Peer Reviewed
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[Journal Article] Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells.2017
Author(s)
Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang KK, Joyce LN, Kalpana R, Tay ST, Suzuki Y, Cho BC, Kuroda D, Arima K, Izumi D, Iwatsuki M, Baba Y, Oki E, Watanabe M, Saya H, Hirakawa K, Baba H, Tan P.
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Journal Title
Gastroenterology
Volume: in press
Issue: 1
Pages: 191-204
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] IDO1 high expression is associated with a poor prognosis in patients with esophageal cancer.2018
Author(s)
Yuki Kiyozumi, Yoshifumi Baba, Taisuke Yagi, Yuki Koga, Tomoyuki Uchihara, Daisuke Kuroda, Hiroshi Sawayama, Ryuichi Krashima, Yukiharu Hiyoshi, Takatsugu Ishimoto, Masaaki Iwatsuki, Yuji Miyamoto, Naoya Yoshida, Hideo Baba.
Organizer
Association for Cancer Research 2018
Related Report
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