| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
The purpose of this study is to elucidate the activation mechanism of the liver resident natural killer (NK) cells with vigorous antitumor activity. We have created a mouse model that weakens the liver resident NK cells, and clarified the function and differentiation mechanism of the liver resident NK cells by the whole liver irradiation model. Moreover, it was revealed that genetic polymorphisms of antitumor molecules are associated with recurrence of liver cancer. Maintaining the activity of NK cells in the liver by gene regulation would lead to a novel treatment for liver cancer.
|
