Analysis of the mechanism of liver resident NK cell activation through the EZH2 epigenetic regulations
| Project/Area Number |
17K10669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肝細胞癌 / ナチュラルキラー細胞 / 肝臓内免疫 / NK細胞 / 肝臓 / エピジェネティック / TRAIL / 癌免疫 |
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| Outline of Final Research Achievements |
The purpose of this study is to elucidate the activation mechanism of the liver resident natural killer (NK) cells with vigorous antitumor activity. We have created a mouse model that weakens the liver resident NK cells, and clarified the function and differentiation mechanism of the liver resident NK cells by the whole liver irradiation model. Moreover, it was revealed that genetic polymorphisms of antitumor molecules are associated with recurrence of liver cancer. Maintaining the activity of NK cells in the liver by gene regulation would lead to a novel treatment for liver cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
肝臓癌は悪性腫瘍死因の第5位であり、根治的な治療を行っても再発することが多い。抗癌剤治療や放射線治療の効果は限定的であり、新規治療法の開発が急務である。肝臓内に存在する抗腫瘍活性の高いNK細胞は、肝癌や肝臓治療により弱体化する。本研究結果は、遺伝子制御を含めた免疫療法につながる礎となる。肝内在性NK細胞の活性を維持できる治療法は、既存の治療法に上乗せ効果が期待でき肝臓癌治療成績のさらなる向上が見込まれる。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Reply: Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity -matched analysis in a single institution.2019
Author(s)
Nakano R, Ohira M, Kobayashi T, Ide K, Tahara H, Kuroda S, Shimizu S, Kimura T, Nagata Y, Aikata H, Chayama K, Ohdan H.
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Journal Title
Surgery.
Volume: 165
Issue: 5
Pages: 1054-1057
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 臓器移植における免疫機能分子一塩基多型の役割.2019
Author(s)
大平真裕, 清水誠一, 今岡祐輝, 佐藤幸毅, 山根宏昭, 秋本修志, 田口和浩, 田中飛鳥, 黒田慎太郎, 田原裕之, 井手健太郎, 小林剛, 田中友加, 大段秀樹
Organizer
第119回日本外科学会定期学術集会
Related Report
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[Presentation] 生体肝移植周術期の門脈圧がアロ免疫応答に与える影響2019
Author(s)
大平真裕, 橋本慎二, 尾上隆司, 今岡祐輝, 佐藤幸毅, 田口和浩, 黒田慎太郎, 田原裕之, 井手健太郎, 小林剛, 田中友加, 大段秀樹
Organizer
第26回日本門脈圧亢進症学会総会
Related Report
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[Presentation] Adjuvant immunotherapy using liver natural killer cells for preventing recurrence of hepatocellular carcinoma in liver transplantation2019
Author(s)
大平真裕, 清水誠一, 今岡祐輝, 佐藤幸毅, 山根宏明, 秋本修志, 田口和浩, 田中飛鳥, 黒田慎太郎, 田原裕之, 井手健太郎, 小林剛, 田中友加, 大段秀樹
Organizer
第31回日本肝胆膵外科学会学術集会.
Related Report
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[Presentation] Impact of Aortic Abdominal Calcification among Living Donor Liver Transplant Recipients; A retrospective study2018
Author(s)
Yuki Imaoka, Masahiro Ohira, Takuya Yano, Ryosuke Nakano, Naoki Tanimine, Seiichi Shimizu, Shintaro Kuroda, Hiroyuki Tahara, Tsuyoshi Kobayashi, Yuka Tanaka, Hideki Ohdan
Organizer
2018 American Transplant Congress
Related Report
Int'l Joint Research
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