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Identification of CSC-specific markers for non-small cell lung cancer and development of lung cancer root therapy

Research Project

Project/Area Number 17K10787
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionKagawa University

Principal Investigator

Liu Dage  香川大学, 医学部, 助教 (30314941)

Co-Investigator(Kenkyū-buntansha) 上野 正樹  香川大学, 医学部, 教授 (30322267)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords非小細胞肺癌 / 癌幹細胞 / 癌 / 肺癌 / マーカー / 治療法
Outline of Final Research Achievements

The treatment results for advanced stage lung cancer are still poor, and there is an urgent need to develop new treatments for advanced stage lung cancer. In recent years, the introduction of the concept of cancer stem cells (CSCs) has led to a better understanding of the mechanisms of cancer development, metastasis, and recurrence. Eradication of cancer stem cells is essential for tumor elimination and prevention of recurrence, and cancer stem cells have become important targets for cancer treatment. In this study, by inducing epithelial-mesenchymal transition, we established a cancer stem cell line for non-small cell lung cancer, which is difficult to identify and isolate cancer stem cells, and obtained basic data for new cancer treatment aiming at radical cure of cancer.

Academic Significance and Societal Importance of the Research Achievements

本研究により,EMT誘導で本来癌幹細胞の同定・分離の困難な非小細胞肺癌に対する癌幹細胞株の確立が短期間かつ高い効率的にできると期待できる.確立した癌幹細胞株を他分野の研究者に提供することもでき,癌幹細胞の制御機構の解明を加速させる.また,本研究の成果は,肺癌だけでなく,消化器癌や婦人科癌など多くの癌腫に応用でき,癌の発生や転移機序への理解を深める,より効率的な新規癌根治治療法の開発に貢献することができる.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (17 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (11 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Overexpression of Antiapoptotic MCL-1 Predicts Worse Overall Survival of Patients With Non-small Cell Lung Cancer2020

    • Author(s)
      NAKANO TAKAYUKI、GO TETSUHIKO、NAKASHIMA NARIYASU、LIU DAGE、YOKOMISE HIROYASU
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 2 Pages: 1007-1014

    • DOI

      10.21873/anticanres.14035

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of Cell-surface Molecular GPR87 With GPR87-suppressing Adenoviral Vector Disturb Tumor Proliferation in Lung Cancer Cells2020

    • Author(s)
      KITA YUSUKE、GO TETSUHIKO、NAKASHIMA NARIYASU、LIU DAGE、TOKUNAGA YOSHIMASA、ZHANG XIA、NAKANO TAKAYUKI、NII KAZUHITO、CHANG SUNG SOO、YOKOMISE HIROYASU
    • Journal Title

      Anticancer Research

      Volume: 40 Issue: 2 Pages: 733-741

    • DOI

      10.21873/anticanres.14004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The clinical significance of autophagy in patients with non small cell lung cancer.2018

    • Author(s)
      Nariyasu Nakashima, Dage Liu, Takayuki Nakano, Xia Zhang, Tetsuhiko Go, Yoshiyuki Kakehi, and Hiroyasu Yokomise
    • Journal Title

      Journal of Clinical Oncology

      Volume: 36:15_suppl Issue: 15_suppl Pages: e24268-e24268

    • DOI

      10.1200/jco.2018.36.15_suppl.e24268

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Takayuki Nakano, Dage Liu, Nariyasu Nakashima, Hiroyasu Yokomise, Kazuhito Nii, Tetsuhiko Go, Shintaro Tarumi, Natsumi Matsuura, Sung soo Chang, Atsushi Fujiwara, and Yoshiyuki Kakehi2018

    • Author(s)
      MCL-1 expression of non-small cell lung cancer as a prognostic factor and MCL-1 as a promising target for gene therapy
    • Journal Title

      Journal of Clinical Oncology

      Volume: 36:15_suppl Issue: 15_suppl Pages: e24236-e24236

    • DOI

      10.1200/jco.2018.36.15_suppl.e24236

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Candidate biomarkers predictive of anthracycline and taxane efficacy against breast cancer.2018

    • Author(s)
      Norimura S, Kontani K, Kubo T, Hashimoto SI, Murazawa C, Kenzaki K, Liu D, Tamaki M, Aki F, Miura K, Yoshizawa K, Tangoku A, Yokomise H.
    • Journal Title

      J Cancer Res There.

      Volume: 14(2) Issue: 2 Pages: 409-415

    • DOI

      10.4103/jcrt.jcrt_1053_16

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Customized Adjuvant Chemotherapy Based on Biomarker Examination May Improve Survival of Patients Completely Resected for Non-small-cell Lung Cancer.2017

    • Author(s)
      Liu D, Nakashima N, Nakano J, Tarumi S, Matsuura N, Nakano T, Nii K, Tokunaga Y, Yokomise H.
    • Journal Title

      Anticancer Res,

      Volume: 37(5) Issue: 5 Pages: 2401-7

    • DOI

      10.21873/anticanres.11591

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 非小細胞肺癌におけるアミノ酸トランスポーターSLC7A11/xCT発現とp53変異との関連2019

    • Author(s)
      劉 大革, 中島 成泰, 中野 貴之, 張 霞, 横見瀬 裕保
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中島 成泰, 劉 大革, 新居和仁, 中野 貴之, 呉 哲彦, 横見瀬裕保2019

    • Author(s)
      ヒストン変異体H3F3Aは悪性細胞株におけるGPR87発現に相関する
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 18FDG-PET SUVmaxは原発性肺癌における病理学的脈管侵襲を術前に予測する強力なバイオマーカーである2018

    • Author(s)
      中島 成泰, 横見瀬 裕保, 藤本 周祐, 芳賀 ななせ, 横田 直哉, 加藤 歩, 藤原 敦史, 松浦 奈都美, 垂水 晋太郎, 中野 貴之, 張 性洙, 劉 大革, 呉 哲彦
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 抗腫瘍剤関連バイオマーカーの評価は肺癌術後の予後改善に寄与するか2018

    • Author(s)
      中野 貴之, 横見瀬 裕保, 呉 哲彦, 劉 大革, 張 性洙, 垂水 晋太郎, 中島 成泰, 松浦 奈都美, 新居 和人, 藤原 敦史, 加藤 歩, 横田 直哉, 芳賀 ななせ, 藤本 周祐
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 非小細胞肺癌におけるオートファジーの臨床的意義2018

    • Author(s)
      劉 大革, 中島 成泰, 中野 貴之, 芳賀 ななせ, 加藤 歩, 横田 直哉, 藤原 敦史, 松浦 奈都美, 垂水 晋太郎, 張 性洙, 呉 哲彦, 横見瀬 裕保
    • Organizer
      第35回日本呼吸器外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 非小細胞肺癌におけるMCL-1発現の臨床的意義2018

    • Author(s)
      中野 貴之, 芳賀 ななせ, 藤本 周祐, 横田 直哉, 加藤 歩, 藤原 敦史, 松浦 奈都美, 中島 成泰, 垂水 晋太郎, 張 性洙, 劉 大革, 呉 哲彦, 横見瀬 裕保
    • Organizer
      第35回日本呼吸器外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 非小細胞肺癌におけるアミノ酸トランスポーターSLC7A11/xCT発現の臨床意義2018

    • Author(s)
      劉 大革, 中島 成泰, 中野 貴之, 張 霞, 横見瀬 裕保
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 非小細胞肺癌におけるオートファジーの臨床的意義について2018

    • Author(s)
      中島 成泰, 劉 大革, 中野 貴之, 呉 哲彦, 横見瀬 裕保
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] MCl-1の発現は非小細胞肺癌の予後因子である2018

    • Author(s)
      中野 貴之, 劉 大革, 中島 成泰, 横見瀬 裕保
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] intratumoral vessel invasion (vascular and lymphatic invasion) has an adverse effect to the survival of patients with NSCLC and may be predicted by preoperative 18F-FDG PET2018

    • Author(s)
      Nariyasu Nakashima, H.Yokomise, D.Liu, T.Go, S.S.Chang, S.Tarumi, N.Matsuura, T.Nakano
    • Organizer
      26th ESTS2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 非小細胞肺癌における抗癌剤耐性遺伝子を標的とした遺伝子治療の基礎研究2017

    • Author(s)
      劉 大革, 中島 成泰, 中野 貴之, 喜田 裕介, 徳永 義昌, 張 霞, 呉 哲彦, 黄 政龍, 横見瀬 裕保.
    • Organizer
      .第76回日本癌学会学術総会,
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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