Searching for molecular markers of postoperative recurrence after surgery for lung cancer and its clinical application
| Project/Area Number |
17K10803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
薄田 勝男 金沢医科大学, 医学部, 教授 (00324046)
本野 望 金沢医科大学, 医学部, 講師 (30634901)
上田 善道 金沢医科大学, 医学部, 教授 (50271375)
町田 雄一郎 金沢医科大学, 金沢医科大学氷見市民病院, 助教 (50460366)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺癌 / 術後再発 / TSHZ2 / PRDX4 / biomarker / 手術 / 再発 / 診断 / 肺外科 |
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| Outline of Final Research Achievements |
Surgery has reduced relapse, new tumors and deaths in patients with lung adenocarcinoma, but survival rate was still lower due to it’s characteristics of early metastasis and recurrence. we performed a microarray expression analysis using a combination of tumor tissues and cell lines based on recurrence or no-recurrence cases.We demonstrated the tumor-suppressive function of TSHZ2 in lung adenocarcinoma. TSHZ2 was found to be highly expressed in most lung adenocarcinoma cell lines and tumor tissues of lung adenocarcinoma patients. The overexpressed plasmids of TSHZ2 led to the dramatic inhibition of cell proliferation, colony formation ability, migration and apoptosis induction in lung adenocarcinoma cells. Notably, the high TSHZ2 expression patients with lung adenocarcinoma was inclined to have less EGFR mutations，but had preferable prognosis. Increased TSHZ2 could restrain EGFR and p-Erk1/2 expression, simultaneously activate p-SAPK/Jnk and p-P38 expression in vitro.
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| Academic Significance and Societal Importance of the Research Achievements |
完全切除はすなわち、完治、つまり再発がない根治ということを意味する。しかし、実際には種々の固形腫瘍で一定の割合で再発する。しかも肺癌の術後再発率は決して低くはない。しかし、病理組織学的評価、腫瘍マーカーなどの臨床的パラメーターはそれなりの再発の予測になるが、それらをもってしても全貌を説明可能ではない。また現在、肺癌では再発率を少しでも減らすために、術後補助化学療法が施行されているが、その真の恩恵を得るのは約5%にすぎない。つまり、再発するであろう、かつ、その薬剤の効果を期待できる母集団に限定される。本研究はその再発するであろう集団の特定につながると思われる。
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] The impact of PRDX4 and the EGFR mutation status on cellular proliferation in lung adenocarcinoma. Mizutani K, Guo X, Shioya A, Zhang J, Zheng J, Kurose N, Ishibashi H, Motono N, U2019
Author(s)
Mizutani K, Guo X, Shioya A, Zhang J, Zheng J, Kurose N, Ishibashi H, Motono N, Uramoto H, Yamada S.
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Journal Title
Int J Med Sci.
Volume: 16
Issue: 9
Pages: 1199-1206
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.2018
Author(s)
Guo X, Noguchi H, Ishii N, Homma T, Hamada T, Hiraki T, Zhang J, Matsuo K, Yokoyama S, Ishibashi H, Fukushige T, Kanekura T, Fujii J, Uramoto H, Tanimoto A,Yamada S.
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Journal Title
Antioxid Redox Signal.
Volume: 30
Issue: 10
Pages: 1271-1284
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression.2018
Author(s)
Kumagai M, Guo X, Wang KY, Izumi H, Tsukamoto M, Nakashima T, Tasaki T, Kurose N, Uramoto H, Sasaguri Y,Kohno K, Yamada S.
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Journal Title
International Journal of Medical Sciences
Volume: 16
Issue: 3
Pages: 416-423
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing2017
Author(s)
Gou Yamamoto, Mari Kikuchi, Shiho Kobayashi, Yoshiko Arai, Kenji Fujiyoshi, Tomokazu Wakatsuki, Miho Kakuta, Yuki Yamane, Yoshihito Iijima, Hideaki Mizutani, Yuki Nakajima, Junko Sudo, Hiroyasu Kinoshita, Futoshi Kurimoto, Hirohiko Akiyama, Hidetaka Uramoto, Hiroshi Sakai, Yoshito Akagi, Kiwamu Akagi
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Journal Title
International journal of oncology
Volume: 50
Issue: 5
Pages: 1579-1589
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Expression of Notch1 and Numb in small cell lung cancer.2017
Author(s)
Kikuchi H, Sakakibara-Konishi J, Furuta M, Yokouchi H, Nishihara H, Yamazaki S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Harada T, Higuchi M, Honjo O, Minami Y, Watanabe N, Oizumi S, Suzuki H, Ishida T, Dosaka-Akita H, Isobe H, Munakata M, Nishimura M.
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Journal Title
Oncotarget
Volume: 8
Issue: 6
Pages: 10348-10358
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunohistochemical profiling of receptor tyrosine kinases, MED12, and TGF-βRII of surgically resected small cell lung cancer, and the potential of c-kit as a prognostic marker2016
Author(s)
Yokouchi H, Nishihara H, Harada T, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Higuchi M, Honjo O, Minami Y, Watanabe N, Goto A, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M
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Journal Title
Oncotarget
Volume: Dec 31
Issue: 24
Pages: 39711-39726
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Prospective study for usefulness of plasma DNA on prediction of third generation EGFR tyrosine kinase inhibitors; The intermediate analysis of S-PLAT study.2019
Author(s)
H. Yoshida, C. Nakashima, N. Matsumoto, K. Iwanaga, N. Ebi, A. Nishiyama, K. Yatera, S. Kuyama, M. Fukuda, S. Ushijima, H. Umeguchi, D. Harada, K. Kashiwabara, T. Suetsugu, N. Fujimoto, F. Tanaka, H. Uramoto, C. Yoshii, K. Nakatomi, N. Sueoka-Aragane
Organizer
ESMO
Related Report
Int'l Joint Research
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[Presentation] Diffusion-Weighted Imaging can differentiate pleural dissemination from malignant pleural mesothelioma, empyema or pleural effusion.2018
Author(s)
Usuda K, Iwai S, Funasaki A, Sekimura A, Motono N, Matoba M, Doai M, Yamada S, Ueda Y, Uramoto H.
Organizer
International Cancer Imaging
Related Report
Int'l Joint Research
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