Neo-angiogenesis induction by pluripotent stem cell Muse as a new therapeutic strategy for severer form of moyamoya disease
| Project/Area Number |
17K10815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
Miki Fujimura 東北大学, 医学系研究科, 非常勤講師 (00361098)
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| Co-Investigator(Kenkyū-buntansha) |
冨永 悌二 東北大学, 大学病院, 教授 (00217548)
新妻 邦泰 東北大学, 医工学研究科, 教授 (10643330)
坂田 洋之 東北大学, 医学系研究科, 非常勤講師 (80722305)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | もやもや病 / 血管新生 / 再生医療 / 幹細胞移植 / 頭蓋外内バイパス術 |
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| Outline of Final Research Achievements |
In the laboratory research, we established a reproducible chronic hypoperfusion model using mice and rat, and found significant neo-angiogenesis and the migration of immune cells to the brain surface after indirect pial synangiosis. Using moyamoya disease patients’ sample, we found increased serum levels of sCD163 (M2 macrophage-associated factor) and CXCL5, suggesting the contribution of intrinsic immune reaction in its pathophysiology （Fujimura et al. Brain Res 2018）. Finally, we found marked expression of endogenous pluripotent stem cells in the arachnoid membrane of moyamoya disease patients, indicating the possible role of endogenous stem cells in the intrinsic angiogenesis in moyamoya disease (Fujimura et al. submitted）.
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| Academic Significance and Societal Importance of the Research Achievements |
厚労省指定難病で原因不明の脳血管障害であるもやもや病における、得意な免疫反応、遺伝子変異の病態に及ぼす影響について新たな知見が得られた。さらに患者クモ膜における内因性多能性幹細胞の発現上昇を見出し、本疾患特有の血管新生のメカニズムを解き明かし、重症例に対する血管新生療法の確立に新たな道を開いた。
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Hemodynamic analysis of the recipient parasylvian cortical arteries for predicting postoperative hyperperfusion during STA-MCA bypass in adult patients with moyamoya disease2019
Author(s)
Zhang J, Li S, Fujimura M, Lau TY, Wu X, Hu M, Zheng H, Xu H, Zhao W, Li X, Chen J
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Journal Title
J Neurosurg
Volume: in press
Issue: 1
Pages: 1-7
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Paradoxical association of symptomatic local vasogenic edema with global cerebral hypoperfusion after direct revascularization surgery for adult moyamoya disease2018
Author(s)
Tashiro R, Fujimura M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T
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Journal Title
Tashiro R, FUJIMURA M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T
Volume: -
Issue: 8
Pages: e172-e176
DOI
Related Report
Peer Reviewed
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