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Neo-angiogenesis induction by pluripotent stem cell Muse as a new therapeutic strategy for severer form of moyamoya disease

Research Project

Project/Area Number 17K10815
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionTohoku University

Principal Investigator

Miki Fujimura  東北大学, 医学系研究科, 非常勤講師 (00361098)

Co-Investigator(Kenkyū-buntansha) 冨永 悌二  東北大学, 大学病院, 教授 (00217548)
新妻 邦泰  東北大学, 医工学研究科, 教授 (10643330)
坂田 洋之  東北大学, 医学系研究科, 非常勤講師 (80722305)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsもやもや病 / 血管新生 / 再生医療 / 幹細胞移植 / 頭蓋外内バイパス術
Outline of Final Research Achievements

In the laboratory research, we established a reproducible chronic hypoperfusion model using mice and rat, and found significant neo-angiogenesis and the migration of immune cells to the brain surface after indirect pial synangiosis. Using moyamoya disease patients’ sample, we found increased serum levels of sCD163 (M2 macrophage-associated factor) and CXCL5, suggesting the contribution of intrinsic immune reaction in its pathophysiology (Fujimura et al. Brain Res 2018). Finally, we found marked expression of endogenous pluripotent stem cells in the arachnoid membrane of moyamoya disease patients, indicating the possible role of endogenous stem cells in the intrinsic angiogenesis in moyamoya disease (Fujimura et al. submitted).

Academic Significance and Societal Importance of the Research Achievements

厚労省指定難病で原因不明の脳血管障害であるもやもや病における、得意な免疫反応、遺伝子変異の病態に及ぼす影響について新たな知見が得られた。さらに患者クモ膜における内因性多能性幹細胞の発現上昇を見出し、本疾患特有の血管新生のメカニズムを解き明かし、重症例に対する血管新生療法の確立に新たな道を開いた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (57 results)

All 2020 2019 2018 2017

All Journal Article (24 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 24 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (32 results) (of which Int'l Joint Research: 15 results,  Invited: 26 results) Book (1 results)

  • [Journal Article] The hemodynamic complexities underlying transient ischemic attacks in early-stage Moyamoya disease: an exploratory CFD study2020

    • Author(s)
      Rashad Sherif、Saqr Khalid M.、Fujimura Miki、Niizuma Kuniyasu、Tominaga Teiji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 3700-3700

    • DOI

      10.1038/s41598-020-60683-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of cortical hemodynamic failure on both subsequent hemorrhagic stroke and effect of bypass surgery in hemorrhagic moyamoya disease: a supplementary analysis of the Japan Adult Moyamoya Trial2020

    • Author(s)
      Takahashi JC, Funaki T, Houkin K, Kuroda S, Fujimura M, Tomata Y, Miyamoto S
    • Journal Title

      J Neurosurg

      Volume: in press Issue: 3 Pages: 1-6

    • DOI

      10.3171/2020.1.jns192392

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuro-endoscopic management of hemorrhagic moyamoya disease in the acute stage: single institute experience2019

    • Author(s)
      Mino M, Fujimura M M, Endo H, Endo T, Sato K, Tominaga T
    • Journal Title

      Neurol Res

      Volume: 41 Issue: 12 Pages: 1097-1103

    • DOI

      10.1080/01616412.2019.1674006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of quantitative cerebral blood flow measurement in the acute stage after revascularization surgery for adult moyamoya disease: Implication for the pathological threshold of local cerebral hyperperfusion2019

    • Author(s)
      Kameyama M, Fujimura M, Tashiro R, Sato K, Endo H, Niizuma K, Mugikura S, Tominaga T
    • Journal Title

      Cerebrovasc Dis

      Volume: 48 Issue: 3-6 Pages: 217-225

    • DOI

      10.1159/000504835

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and risk factors of the watershed shift phenomenon after superficial temporal artery-middle cerebral artery anastomosis for adult moyamoya disease2019

    • Author(s)
      Tashiro R, Fujimura M, Kameyama M, Mugikura S, Endo H, Takeuchi Y, Tomata Y, Niizuma K, Tominaga T
    • Journal Title

      Cerebrovasc Dis

      Volume: 47 Issue: 3-4 Pages: 178-187

    • DOI

      10.1159/000500802

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study2019

    • Author(s)
      Tashiro R, Niizuma K, Khor SS, Tokunaga K, Fujimura M, Sakata H, Endo H, Inoko H, Ogasawara K, Tominaga T
    • Journal Title

      PLoS One

      Volume: 14 Issue: 8 Pages: e0220858-e0220858

    • DOI

      10.1371/journal.pone.0220858

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic analysis of Ring Finger Protein 213 (RNF213) c.14576G>A polymorphism in patients with vertebral artery dissection: a comparative study with moyamoya disease2019

    • Author(s)
      Tashiro R, Fujimura M, Sakata H, Endo H, Tomata Y, Sato-Maeda M, Niizuma K, Tominaga T
    • Journal Title

      Neurol Res

      Volume: 41 Issue: 9 Pages: 811-816

    • DOI

      10.1080/01616412.2019.1615726

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of direct revascularization surgery for hemorrhagic moyamoya syndrome as a late complication of cranial irradiation for childhood craniopharyngioma2019

    • Author(s)
      Kato Y, FUJIMURA M, Sato K, Endo H, Tominaga T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: - Issue: 5 Pages: e46-e50

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.01.033

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Hemorrhage-prone Anastomoses in Asymptomatic Moyamoya Disease; A Comparative Study with Japan Adult Moyamoya Trial2019

    • Author(s)
      Yamamoto S, Funaki T, Fujimura M, Takahashi JC, Uchino H, Houkin K, Tominaga T, Miyamoto S, Kuroda S
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 28 Issue: 11 Pages: 104328-104328

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.104328

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic analysis of the recipient parasylvian cortical arteries for predicting postoperative hyperperfusion during STA-MCA bypass in adult patients with moyamoya disease2019

    • Author(s)
      Zhang J, Li S, Fujimura M, Lau TY, Wu X, Hu M, Zheng H, Xu H, Zhao W, Li X, Chen J
    • Journal Title

      J Neurosurg

      Volume: in press Issue: 1 Pages: 1-7

    • DOI

      10.3171/2019.10.jns191207

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of Choroidal Collateral Vessels on De Novo Hemorrhage in Moyamoya Disease: Analysis of Nonhemorrhagic Hemispheres in the Japan Adult Moyamoya Trial2019

    • Author(s)
      Funaki T, Takahashi JC, Houkin K, Kuroda S, FUJIMURA M, Tomata Y, Miyamoto S
    • Journal Title

      J Neurosurg

      Volume: - Issue: 2 Pages: 408-414

    • DOI

      10.3171/2018.10.jns181139

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] もやもや病:診断基準改定と外科治療に関する最新知見2019

    • Author(s)
      藤村幹、冨永悌二
    • Journal Title

      脳神経外科ジャーナル

      Volume: 28 Pages: 789-795

    • NAID

      130007772474

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemorrhagic Moyamoya Disease: A Recent Update2019

    • Author(s)
      FUJIMURA M, Tominaga T
    • Journal Title

      J Korean Neurosurg Soc

      Volume: 62 Issue: 2 Pages: 136-143

    • DOI

      10.3340/jkns.2018.0101

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intrinsic development of choroidal and thalamic collaterals in hemorrhagic-onset moyamoya disease: Case control study of the Japan Adult Moyamoya trial2018

    • Author(s)
      FUJIMURA M, Funaki T, Houkin K, Takahashi JC, Kuroda S, Tomata Y, Tominaga T, Miyamoto S
    • Journal Title

      J Neurosurg

      Volume: - Issue: 5 Pages: 1453-1459

    • DOI

      10.3171/2017.11.jns171990

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Paradoxical association of symptomatic local vasogenic edema with global cerebral hypoperfusion after direct revascularization surgery for adult moyamoya disease2018

    • Author(s)
      Tashiro R, Fujimura M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T
    • Journal Title

      Tashiro R, FUJIMURA M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T

      Volume: - Issue: 8 Pages: e172-e176

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.03.002

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biphasic development of focal cerebral hyperperfusion after revascularization surgery for adult moyamoya disease associated with autosomal dominant polycystic kidney disease2018

    • Author(s)
      Tashiro R, FUJIMURA M, Endo H, Endo T, Niizuma K, Tominaga T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 27 Issue: 11 Pages: 3256-3260

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.07.024

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low frequency of cervicocranial artery involvement in Japanese with renal artery fibromuscular dysplasia compared with that of Caucasians2018

    • Author(s)
      Eikan Mishima, Shu Umezawa, Takehiro Suzuki, Miki Fujimura, Michiaki Abe, Junichiro Hashimoto, Takaaki Abe, Sadayoshi Ito
    • Journal Title

      Clin Exp Nephrol

      Volume: 印刷中 Issue: 6 Pages: 1294-1299

    • DOI

      10.1007/s10157-018-1575-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] もやもや病に対する血行再建術:術式選択と周術期管理の現状と課題2018

    • Author(s)
      藤村幹、冨永悌二
    • Journal Title

      脳卒中の外科

      Volume: 46 Pages: 249-253

    • NAID

      130007436996

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] もやもや病(ウイリス動脈輪閉塞症)診断・治療ガイドライン(改訂版)2018

    • Author(s)
      冨永悌二、鈴木則宏、宮本享、小泉明夫、黒田敏、高橋淳、藤村幹、寳金清博
    • Journal Title

      脳卒中の外科

      Volume: 46 Pages: 1-24

    • NAID

      130006350165

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased serum production of soluble CD163 and CXCL5 in patients with moyamoya disease: Involvement of intrinsic immune reaction in its pathogenesis2018

    • Author(s)
      Fujimura M, Fujimura T, Kakizaki A, Sato-Maeda M, Niizuma K, Tomata Y, Aiba S, Tominaga T
    • Journal Title

      Brain Res

      Volume: 1679 Pages: 39-44

    • DOI

      10.1016/j.brainres.2017.11.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: Cerebral hyperperfusion and remote ischemia caused by the 'watershed shift'2017

    • Author(s)
      Tu XK, Fujimura M, Rashad S, Mugikura S, Sakata H, Niizuma K, Tominaga T
    • Journal Title

      Neurosurg Rev

      Volume: - Issue: 3 Pages: 507-512

    • DOI

      10.1007/s10143-017-0845-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Sequel of Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan2017

    • Author(s)
      Mugikura S, Fujimura M, Takahashi S, Takase K
    • Journal Title

      Radiology

      Volume: 284 Issue: 1 Pages: 301-303

    • DOI

      10.1148/radiol.2017170252

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Navigation-guided clipping of a de novo aneurysm associated with superficial temporal artery-middle cerebral artery bypass combined with indirect pial synangiosis in a patient with moyamoya disease2017

    • Author(s)
      Aburakawa D, Fujimura M, Niizuma K, Sakata H, Endo H, Tominaga T
    • Journal Title

      Neurosurg Rev

      Volume: 40 Issue: 3 Pages: 517-521

    • DOI

      10.1007/s10143-017-0866-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex.2017

    • Author(s)
      Sato-Maeda M, Fujimura M, Rashad S, Morita-Fujimura Y, Niizuma K, Sakata H, Ikawa S, Tominaga T.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 26 Issue: 9 Pages: 1904-1911

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.06.032

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Indirect and combined bypass technique for moyamoya disease2020

    • Author(s)
      Fujimura M, Tominaga T
    • Organizer
      Bypass 2020 (Zurich, Switzerland)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Post-operative hyperperfusion after bypass: Diagnosis and management [special consideration for moyamoya disease]2020

    • Author(s)
      Fujimura M, Tominaga T
    • Organizer
      Bypass 2020 (Zurich, Switzerland)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current status of EC-IC bypass; new evidence in Moyamoya disease2019

    • Author(s)
      Fujimura M, Tominaga T
    • Organizer
      Congress of Neurological Surgeons 2019 (San Francisco, USA)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current status of revascularization surgery for Moyamoya disease2019

    • Author(s)
      Fujimura M
    • Organizer
      University of Utah 【Grand Round Lecture 2019】
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current status of revascularization surgery for moyamoya disease2019

    • Author(s)
      Fujimura M, Tominaga T
    • Organizer
      The First Moyamoya Disease Meeting in Central China Area. 2019 (Wuhan, China)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current status of EC-IC bypass for Moyamoya disease: Surgical procedure and peri-operative management2019

    • Author(s)
      Fujimura M, Tominaga T
    • Organizer
      The 18th ASEAN Neurosurgical Meeting, 2019 (Hanoi, Vietnam)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current status of revascularization surgery for moyamoya disease; Significance of surgical technique and peri-operative care2019

    • Author(s)
      Fujimura M, Tominaga T
    • Organizer
      The 11th Conference of Chinese-Japanese Neurosurgery Committee 2019 (Urumqi, China)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 本邦におけるもやもや病研究:その変遷と叡智について2019

    • Author(s)
      藤村幹、冨永悌二
    • Organizer
      第78回日本脳神経外科学会総会 (大阪)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳動脈瘤手術の基本手技と最近の術前診断2019

    • Author(s)
      藤村幹
    • Organizer
      第78回日本脳神経外科学会総会 (大阪)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 乳幼児もやもや病に対する外科治療の現状と課題2019

    • Author(s)
      藤村幹、林俊哲、冨永悌二
    • Organizer
      第48回日本脳卒中の外科学会総会 (横浜)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 出血発症もやもや病の病態と治療2019

    • Author(s)
      藤村幹、冨永悌二
    • Organizer
      第44回日本脳卒中学会総会 (横浜)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] もやもや病に対する頭蓋外内バイパス術 基本手技とpitfall回避の工夫2019

    • Author(s)
      藤村幹
    • Organizer
      第39回日本脳神経外科コングレス総会 (横浜)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 成人もやもや病に対するSTA-MCAバイパス術後急性期の脳循環動態と臨床像についての検討2019

    • Author(s)
      藤村幹、田代亮介、亀山昌幸、佐藤健一、遠藤英徳、新妻邦泰、冨永悌二
    • Organizer
      第62回 日本脳循環代謝学会総会 (仙台)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] もやもや病に対する複合頭蓋外内バイパス術-周術期における血圧管理と抗血小板剤の役割2019

    • Author(s)
      藤村幹
    • Organizer
      第62回 日本脳循環代謝学会総会 (仙台)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] もやもや病に対する複合血行再建術におけるチタン製・生体性吸収性プレート併用・頭蓋形成の長期成績2019

    • Author(s)
      藤村幹、冨永悌二
    • Organizer
      第12回日本整容脳神経外科学会総会 (岡山)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 頭蓋内動脈狭窄症の診断:もやもや病との鑑別の重要性について2019

    • Author(s)
      藤村幹、冨永悌二
    • Organizer
      第38回The Mt. Fuji Workshop on CVD (横浜)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Hemorrhagic Moyamoya disease; Current management strategy based on its intrinsic angio-architecture.2018

    • Author(s)
      Fujimura M, Tominaga T.
    • Organizer
      The 6th Emirates International Neurosurgical Conference. 2018 (Dubai, United Arab Emirates)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantitative cerebral blood flow analysis to predict cerebral hyperperfusion syndrome after direct revascularization surgery for moyamoya disease.2018

    • Author(s)
      Fujimura M, Tominaga T.
    • Organizer
      The 5th International Moyamoya Meeting, 2018 (Seoul, Korea)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Long term outcome after combined bypass revascularization surgery for pediatric moyamoya disease.2018

    • Author(s)
      Fujimura M, Tominaga T.
    • Organizer
      The 5th International Moyamoya Meeting, 2018 (Seoul, Korea)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Hemorrhagic Moyamoya disease; Current management strategy based on its intrinsic angio-architecture.2018

    • Author(s)
      Fujimura M, Tominaga T.
    • Organizer
      2018 Donghu Neurosurgery Forum. 2018 (Wuhan, China)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Efficacy and safety of combined revascularization surgery for Moyamoya disease.2018

    • Author(s)
      Fujimura M, Tominaga T.
    • Organizer
      The 9th European Japanes Cerebrovascular Congress. 2018 (Milan, Italy)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] もやもや病:診断基準改訂と病因・病態・外科治療の最新知見.2018

    • Author(s)
      藤村幹、冨永悌二.
    • Organizer
      第38回日本脳神経外科コングレス総会. 2018 (大阪)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] くも膜下出血の診断と治療.2018

    • Author(s)
      藤村幹、佐藤健一、遠藤英徳、冨永悌二.
    • Organizer
      第44回 日本脳卒中学会. 2019 (横浜)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] もやもや病におけるM2型マクロファージ関連因子sCD163の発現動態に関する検討.2018

    • Author(s)
      藤村幹、冨永悌二.
    • Organizer
      第37回 The Mt. Fuji Workshop on CVD. 2018 (名古屋)
    • Related Report
      2018 Research-status Report
  • [Presentation] 頭蓋内狭窄の外科治療:もやもや病とその周辺.2018

    • Author(s)
      藤村幹、冨永悌二.
    • Organizer
      日本脳神経外科学会 第77回学術総会. 2018 (仙台)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 乳幼児もやもや病に対する外科治療の現状と課題.2018

    • Author(s)
      藤村幹、林俊哲、冨永悌二.
    • Organizer
      第48回日本脳卒中の外科学会. 2019(横浜)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 出血発症もやもや病の病態と治療.2018

    • Author(s)
      藤村幹、冨永悌二.
    • Organizer
      第44回 日本脳卒中学会. 2019(横浜)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] もやもや病に対する直接間接複合血行再建術:頭蓋形成における生体性吸収性プレート併用法の長期成績2017

    • Author(s)
      藤村幹,遠藤英徳,新妻邦泰,坂田洋之,冨永悌二
    • Organizer
      第9回日本整容脳神経外科研究会(甲府)
    • Related Report
      2017 Research-status Report
  • [Presentation] Genetics and basic pathology of Moyamoya disease: Update2017

    • Author(s)
      FUJIMURA M, Tominaga T
    • Organizer
      WFNS Foundation/Beijing Live Surgery Seminar (Beijing, China)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of EC-IC bypass for Moyamoya disease2017

    • Author(s)
      FUJIMURA M, Tominaga T
    • Organizer
      The 17th Annual Meeting of Cerebrovascular Society in India (New Dehli, India)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Current status and limitation of the basic research of moyamoya disease using RNF213 mutant mice; Prospect for the future clinical application2017

    • Author(s)
      FUJIMURA M, Niizuma K, Kanoke A, Fujimura T, Kure S, Tominaga T
    • Organizer
      第76回日本脳神経外科学会 学術総会(名古屋)
    • Related Report
      2017 Research-status Report
  • [Presentation] Efficacy of direct/indirect combined revascularization surgery for adult moyamoya disease: Significance of perioperative management based on hemodynamic study2017

    • Author(s)
      FUJIMURA M,TominagaT
    • Organizer
      International Conference of Cerebrovascular Surgery 2017 (Nagoya)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Moyamoya disease explored th. RNF2132017

    • Author(s)
      FUJIMURA M, Kure S, Tominaga T
    • Total Pages
      185
    • Publisher
      Springer
    • ISBN
      9789811027109
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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