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The influence to the vasoconstriction by subarachnoid hemorrhage and the specific mechanism for the developmental of vasospasm under the environment marked by elevated intracranial pressure.

Research Project

Project/Area Number 17K10817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionAkita University

Principal Investigator

TAKAHASHI MASATAKA  秋田大学, 医学部附属病院, 講師 (60321999)

Co-Investigator(Kenkyū-buntansha) 清水 宏明  秋田大学, 医学系研究科, 教授 (20506638)
Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordscerebral vasospasm / 脳血管攣縮 / クモ膜下血腫 / pressurized artery / クモ膜下出血 / 脳血管れん縮 / 脳圧亢進 / 脳神経疾患 / 脳血管障害 / くも膜下出血
Outline of Final Research Achievements

We formulated a hypothesis that the rapid increase in intracranial pressure caused by subarachnoid hemorrhage and the subsequent increased environment in brain had an effect as an accelerator factor of delayed cerebral vasospasm. and studied the vasoconstrictor mechanism in an environment with increased intracranial pressure at the onset of subarachnoid hemorrhage .
Using a rat cerebral vasospasm model, we planned to study vascular reactivity in a physiological environment using the pressurized artery method. We planned to evaluate vascular contractility. by creating a simulated environment in a thermostatic chamber with increased pressure. Physiologically alive and active rat blood vessels that connective to glass tubes were used. However, no experimental results were obtained in which increased intracranial pressure contributed to increased vasospasm.

Academic Significance and Societal Importance of the Research Achievements

クモ膜下出血による頭蓋内圧上昇が血管リモデリングを誘導し、遅発性脳血管攣縮を発生させる促進因子として影響を与えているという仮説は証明できなかったものの、本仮説を証明することができれば、クモ膜下出血の治療ににおいて、脳動脈瘤破裂の治療とともに、頭蓋内圧をコントロールすることをターゲットにした治療に重きを置くことで予後改善に効果をもたらす可能性がある。
本研究については、生理的活性を保ちながら血管を採取・扱いやすい、長時間生理的活動性を維持できるように技術を改良するとともに恒温槽チャンバーを改良して、液体が蒸発しないように改良を行い、再挑戦したい。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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