Clarification of mechanisms of aneurysmal growth and rupture by quantification of 3D-domain hemodynamic irregularity

• Project/Area Number: 17K10825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Mie University
• Principal Investigator: SUZUKI Hidenori 三重大学, 医学系研究科, 教授 (90345976)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳動脈瘤 / 数値流体力学

Outline of Final Research Achievements

The investigators performed computational fluid dynamics analyses, and made new hemodynamic parameters which could quantitatively measure complicated 3-dimensional fluid patterns in the dome of cerebral aneurysms. The parameter measurements may reflect the irregularity of aneurysm morphology, and showed a well correlation to the growth or rupture of cerebral aneurysms. In addition, the parameter could be applied to the simulation of treatment efficacy of endovascular treatment for a large and complex aneurysm.

Academic Significance and Societal Importance of the Research Achievements

脳動脈瘤は破裂すると、くも膜下出血となり、生命に関わる。脳動脈瘤は一般人口の約４％が持つとされ、決して稀ではないが脳動脈瘤全体での破裂率は低く、手術合併症のリスクを冒して全例で予防的手術を受けるのは非現実的である。従来より、不整な形状の脳動脈瘤は破裂リスクが高いことが知られているが、その評価を客観的に捉えることは出来ずに今日に至っている。本研究により脳動脈瘤の不整な形状を客観的に評価可能となり、脳動脈瘤の破裂リスク評価に応用可能となれば、破裂リスクの高い脳動脈瘤を選別し治療可能となり、その社会的意義は大きいと考える。

Research Products

• [Journal Article] Quantification of hemodynamic irregularity using oscillatory velocity index in the associations with the rupture status of cerebral aneurysms (2018)
  • Author(s): Satoru Tanioka, Fujimaro Ishida, Tomoyuki Kishimoto, Masanori Tsuji, Katsuhiro Tanaka, Shinichi Shimosaka, Mitsuru Toyoda, Nobuhisa Kashiwagi, Takanori Sano, Hidenori Suzuki
  • Journal Title: Journal of NeuroInterventional Surgery Volume: - Issue: 6 Pages: 614-617
  • DOI: 10.1136/neurintsurg-2018-014489
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 脳動脈瘤頭蓋内ステント留置の治療効果予測技術の開発 -多孔質媒体モデルを用いた数値流体力学による血行力学的評価- (2018)
  • Author(s): 石田藤麿、辻正範、谷岡悟、田中克浩、霜坂辰一、鈴木秀謙
  • Journal Title: 三重医報 Volume: 696 Pages: 28-30
  • Peer Reviewed
• [Journal Article] Hemodynamic characteristics of hyperplastic remodeling lesions in cerebral aneurysms (2018)
  • Author(s): Furukawa Kazuhiro、Ishida Fujimaro、Tsuji Masanori、Miura Yoichi、Kishimoto Tomoyuki、Shiba Masato、Tanemura Hiroshi、Umeda Yasuyuki、Sano Takanori、Yasuda Ryuta、Shimosaka Shinichi、Suzuki Hidenori
  • Journal Title: PLoS One Volume: 13 Issue: 1 Pages: e0191287-e0191287
  • DOI: 10.1371/journal.pone.0191287
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hemodynamic Differences Between Ruptured and Unruptured Cerebral Aneurysms Simultaneously Existing in the Same Location: 2 Case Reports and Proposal of a Novel Parameter Oscillatory Velocity Index (2017)
  • Author(s): Sano Takanori、Ishida Fujimaro、Tsuji Masanori、Furukawa Kazuhiro、Shimosaka Shinichi、Suzuki Hidenori
  • Journal Title: World Neurosurg Volume: 98 Pages: 868.e5-868.e10
  • DOI: 10.1016/j.wneu.2016.12.047
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Computational fluid dynamics for predicting delayed cerebral ischemia after subarachnoid hemorrhage (2017)
  • Author(s): Shiba M, Ishida F, Furukawa K, Tsuji M, Shimosaka S, Suzuki H
  • Journal Title: J Neurol Disord Stroke Volume: 5 Pages: 1120-1120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Case of Vertebral Artery Fusiform Aneurysm Treated by Flow Alteration: Successful Prediction of Therapeutic Effects Using Computational Fluid Dynamics (2017)
  • Author(s): Miura Yoichi、Ishida Fujimaro、Kamei Yusuke、Tsuji Masanori、Shiba Masato、Tanemura Hiroshi、Umeda Yasuyuki、Shimosaka Shinichi、Suzuki Hidenori
  • Journal Title: NMC Case Report Journal Volume: 4 Issue: 4 Pages: 107-110
  • DOI: 10.2176/nmccrj.cr.2017-0025
  • NAID: 130006110906
  • ISSN: 2188-4226
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationships of Morphologic Parameters and Hemodynamic Parameters Determined by Computational Fluid Dynamics Analysis with the Severity of Subarachnoid Hemorrhage (2017)
  • Author(s): Shiba Masato、Ishida Fujimaro、Furukawa Kazuhiro、Tanemura Hiroshi、Tsuji Masanori、Shimosaka Shinichi、Suzuki Hidenori
  • Journal Title: Journal of Neuroendovascular Therapy Volume: 11 Issue: 10 Pages: 512-519
  • DOI: 10.5797/jnet.oa.2016-0099
  • NAID: 130006177989
  • ISSN: 1882-4072, 2186-2494
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Computational fluid dynamics (CFD) using porous media modeling predicts recurrence after coiling of cerebral aneurysms (2017)
  • Author(s): Umeda Yasuyuki、Ishida Fujimaro、Tsuji Masanori、Furukawa Kazuhiro、Shiba Masato、Yasuda Ryuta、Toma Naoki、Sakaida Hiroshi、Suzuki Hidenori
  • Journal Title: PLoS One Volume: 12 Issue: 12 Pages: e0190222-e0190222
  • DOI: 10.1371/journal.pone.0190222
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Possibility for preoperative diagnosis of cerebral aneurysm walls based on hemodynamics using computational fluid dynamics (CFD) (2019)
  • Author(s): Kishimoto T, Ishida F, Tsuji M, Tanioka S, Tanaka K, Shimosaka T, Shiba M, Miura Y, Suzuki H
  • Organizer: The 14th Korea-Japan Joint Conference on Surgery for Cerebral Stroke
  • Int'l Joint Research
• [Presentation] Computational fluid dynamics for cerebral aneurysms in clinical settings (2019)
  • Author(s): Shiba M, Suzuki H
  • Organizer: The 14th Korea-Japan Joint Conference on Surgery for Cerebral Stroke
  • Int'l Joint Research / Invited
• [Presentation] Computational fluid dynamics for predicting the recurrence of unruptured cerebral aneurysm after stent-assisted coil embolization (2019)
  • Author(s): Shiba M, Suzuki H
  • Organizer: The 15th International Conference on Subarachnoid Hemorrhage (ISAH) 2019
  • Int'l Joint Research
• [Presentation] Local hemodynamics of rupture points of cerebral aneurysms evaluated with computational fluid dynamics (CFD) (2019)
  • Author(s): Ishida F, Suzuki H
  • Organizer: The 15th International Conference on Subarachnoid Hemorrhage (ISAH) 2019
  • Int'l Joint Research
• [Presentation] CFD for cerebral aneurysms in clinical settings (2018)
  • Author(s): Fujimaro Ishida, Hidenori Suzuki
  • Organizer: 9th European-Japanese Cerebrovascular Congress
  • Int'l Joint Research / Invited
• [Presentation] Computational fluid dynamics simulations of flow alteration treatment for cerebral aneurysms (2018)
  • Author(s): Hidenori Suzuki, Fujimaro Ishida
  • Organizer: The 2nd Meeting of China-Japan Neurosurgery Alliance (The 10th China-Japan Friendship Neurosurgical Symposium)
  • Int'l Joint Research
• [Presentation] 脳動脈瘤の流体解析とスパズムへの挑戦 (2018)
  • Author(s): 鈴木秀謙
  • Organizer: 第30回弘前脳疾患臨床セミナー
  • Invited
• [Presentation] Computatinal fluid dynamics in subarachnoid hemorrhage: potential applications for early detection of delayed cerebral ischemia (2017)
  • Author(s): Masato Shiba, Hidenori Suzuki
  • Organizer: The 14th International Conference on Neurovascular Events after Subarachnoid Hemorrhage
  • Int'l Joint Research
• [Presentation] 非ニュートン流体特性を設定した数値流体力学 (CFD)による頚部頚動脈狭窄症の血行力学的評価 (2017)
  • Author(s): 田中 克浩, 石田 藤麿, 山本 秀樹, 川村 公人, 岸本 智之, 谷岡 悟, 辻 正範, 霜坂 辰一, 鈴木 秀謙
  • Organizer: 一般社団法人日本脳神経外科学会第76回学術集会
• [Remarks] 三重大学脳神経外科
  • URL: http://www.medic.mie-u.ac.jp/neurosurgery/research/index/index.html
• [Remarks] 三重大学大学院脳神経外科学 臨床・研究活動
  • URL: http://www.medic.mie-u.ac.jp/neurosurgery/research/index/index.html