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Visualization of epileptogenic foci of MRI non-lesional neocortical epilepsy patients by 7T-MRI

Research Project

Project/Area Number 17K10888
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionNiigata University

Principal Investigator

Fujii Yukihiko  新潟大学, 脳研究所, 教授 (40283014)

Co-Investigator(Kenkyū-buntansha) 福多 真史  新潟大学, 脳研究所, 非常勤講師 (00361907)
大石 誠  新潟大学, 脳研究所, 准教授 (00422593)
松澤 等  新潟大学, 脳研究所, 非常勤講師 (70303170)
柿田 明美  新潟大学, 脳研究所, 教授 (80281012)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsMRI陰性新皮質てんかん / 7テスラMRI / 機能的脳疾患 / 診療教育拠点 / 教育的診療教育拠点形成 / 教育的診療研究拠点形成 / 7テスラMRI
Outline of Final Research Achievements

This three-year prospective study was intended to visualize epileptogenic foci, as organic lesions, of non-lesional neocortical epilepsy patients by means of our imaging protocol including 7T-MRI and to understand the present status of these patients. However, the study was suspended for a long period because of mechanical failure of the 7T-MRI system, followed by the pandemic of coronavirus disease 2019 (COVID-19) pandemic. Therefore, the study period was finally extended to 5 years to catch up with our study schedule. Unfortunately, although 7T-MRI studies did not restart until the end of the study due to the protracted COVID-19 situation, we could obtain the following results: our imaging protocol could potentially visualize the epileptogenic foci of non-lesional neocortical epilepsy patients and provide insights into the present status of these patients.

Academic Significance and Societal Importance of the Research Achievements

この成果によって「MRI陰性新皮質てんかん」の器質的焦点の確実な切除が可能となり、発作を消失させることが期待できる。延いては、それにより全国に数万人存在すると予想される「MRI陰性新皮質てんかん」患者の発作を改善し、社会復帰させることが期待できる。てんかん発作に悩まされる患者自身および社会に齎される恩恵は計り知れない。またてんかんを始めとした機能的脳疾患に関わる高度専門医療人(医師、検査技師、看護師、等の医療職)養成、先進的診療実践、原因究明・新規治療法の開発等の高度研究の遂行を可能にする教育的診療研究拠点形成に向けたプロジェクトを前進させること出来た。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (98 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (70 results) (of which Int'l Joint Research: 20 results,  Peer Reviewed: 70 results,  Open Access: 36 results) Presentation (28 results) (of which Int'l Joint Research: 5 results,  Invited: 17 results)

  • [Journal Article] Non-contrast-enhanced silent magnetic resonance angiography for assessing cerebral aneurysms after PulseRider treatment2022

    • Author(s)
      Suzuki T, Hasegawa H, Ando K, Shibuya K, Takahashi H, Saito S, Oishi M, Fujii Y.
    • Journal Title

      Jpn J Radiol

      Volume: 印刷中 Issue: 9 Pages: 979-985

    • DOI

      10.1007/s11604-022-01276-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth2022

    • Author(s)
      Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M.
    • Journal Title

      Neurochem Res

      Volume: 印刷中 Issue: 9 Pages: 2668-2682

    • DOI

      10.1007/s11064-022-03580-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E mutant high-grade glioma2022

    • Author(s)
      Sasame J, Ikegaya N, Kawazu M, Natsumeda M, Hayashi T, Isoda M, Satomi K, Tomiyama A, Oshima A, Honma H, Miyake Y, Takabayashi K, Nakamura T, Ueno T, Matsushita Y, Iwashita H, Kanemaru Y, Murata H, Ryo A, Terashima K, Yamanaka S, Fujii Y, Mano H, Komori T, Ichimura K, Cahill DP, Wakimoto H, Yamamoto T, Tateishi K.
    • Journal Title

      Clin Cancer Res

      Volume: 印刷中 Issue: 11 Pages: 2425-2439

    • DOI

      10.1158/1078-0432.ccr-21-3622

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinicopathological risk factors for a poor prognosis of primary central nervous system lymphoma in elderly patients in the Tohoku and Niigata area: a multicenter, retrospective, cohort study of the Tohoku Brain Tumor Study Group2022

    • Author(s)
      Asano K, Yamashita Y, Ono T, Natsumeda M, Beppu T, Matsuda K, Ichikawa M, Kanamori M, Matsuzaka M, Kurose A, Fumoto T, Saito K, Sonoda Y, Ogasawara K, Fujii Y, Shimizu H, Ohkuma H, Kitanaka C, Kayama T, Tominaga T.
    • Journal Title

      Brain Tumor Pathol

      Volume: 印刷中 Issue: 3 Pages: 139-150

    • DOI

      10.1007/s10014-022-00427-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-Term Characteristics of De Novo Bleb Formation at the Aneurysm Neck After Coil Embolization in Unruptured Cerebral Aneurysms2022

    • Author(s)
      Suzuki T, Hasegawa H, Ando K, Shibuya K, Takahashi H, Saito S, Oishi M, Fujii Y.
    • Journal Title

      World Neurosurg

      Volume: 161 Pages: e767-e775

    • DOI

      10.1016/j.wneu.2022.02.092

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of cortical activation in human brain by flavoprotein fluorescence imaging2022

    • Author(s)
      Mitsuhashi D, Hishida R, Oishi M, Hiraishi T, Natsumeda M, Shibuki K, Fujii Y.
    • Journal Title

      J Neurosurg

      Volume: 印刷中 Issue: 4 Pages: 1-9

    • DOI

      10.3171/2022.1.jns212542

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Repositioning Therapy for Drug-Resistant Glioblastoma: In Vivo Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide2022

    • Author(s)
      Eda T, Okada M, Ogura R, Tsukamoto Y, Kanemaru Y, Watanabe J, On J, Aoki H, Oishi M, Takei N, Fujii Y, Natsumeda M.
    • Journal Title

      Cancers (Basel)

      Volume: 14 Issue: 3 Pages: 770-770

    • DOI

      10.3390/cancers14030770

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical Strategy for Directional Deep Brain Stimulation2022

    • Author(s)
      Masuda H, Shirozu H, Ito Y, Fukuda M, Fujii Y.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 62 Issue: 1 Pages: 1-12

    • DOI

      10.2176/nmc.ra.2021-0214

    • NAID

      130008141894

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Real-World status and risk factors for a poor prognosis in elderly patients with primary central nervous system malignant lymphomas: a multicenter, retrospective cohort study of the Tohoku Brain Tumor Study Group2022

    • Author(s)
      Asano K, Yamashita Y, Ono T, Natsumeda M, Beppu T, Matsuda K, Ichikawa M, Kanamori M, Matsuzaka M, Kurose A, Saito K, Sonoda Y, Ogasawara K, Fujii Y, Shimizu H, Ohkuma H, Kitanaka C, Kayama T, Tominaga T.
    • Journal Title

      Int J Clin Oncol

      Volume: 27 Issue: 1 Pages: 77-94

    • DOI

      10.1007/s10147-021-02042-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endovascular treatment of an infectious aneurysm using the selective provocative test and transcranial motor evoked potential monitoring under general anesthesia: a case report2022

    • Author(s)
      Ando K, Hiraishi T, Oishi M, Hasegawa H, Kikuchi B, Natsumeda M, Suzuki T, Saito S, Ota T, Yoshida Y, Fujii Y.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 164 Issue: 5 Pages: 1265-1269

    • DOI

      10.1007/s00701-021-05001-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 グリオーマ-現在の常識と近未来のスタンダード Ⅱグリオーマの疫学と診断 -▼TOPICS-グリオーマの低侵襲的診断法-Liquid biopsyの現状および展望2021

    • Author(s)
      Natsumeda M, On J, Watanabe J, Tsukamoto Y, Okada M, Fujii Y, Adachi J, Nishikawa R.
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 49 Issue: 3 Pages: 527-534

    • DOI

      10.11477/mf.1436204425

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2021-05-10
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deep learning-based diagnosis of temporal lobe epilepsy associated with hippocampal sclerosis: An MRI study2021

    • Author(s)
      Ito Y, Fukuda M, Matsuzawa H, Masuda H, Kobayashi Y, Hasegawa N, Kitaura H, Kakita A, Fujii Y.
    • Journal Title

      Epilepsy Res

      Volume: 178 Pages: 106815-106815

    • DOI

      10.1016/j.eplepsyres.2021.106815

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of 2-Hydroxyglutarate by 3.0-Tesla Magnetic Resonance Spectroscopy in Gliomas with Rare IDH Mutations: Making Sense of "False-Positive" Cases2021

    • Author(s)
      Natsumeda M, Igarashi H, Gabdulkhaev R, Takahashi H, Motohashi K, Ogura R, Watanabe J, Tsukamoto Y, Okamoto K, Kakita A, Nakada T, Fujii Y.
    • Journal Title

      Diagnostics (Basel)

      Volume: 11 Issue: 11 Pages: 2129-2129

    • DOI

      10.3390/diagnostics11112129

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Japan Neurosurgical Database: Statistics Update 2018 and 20192021

    • Author(s)
      Iihara K, Saito N, Suzuki M, Date I, Fujii Y, Houkin K, Inoue T, Iwama T, Kawamata T, Kim P, Kinouchi H, Kishima H, Kohmura E, Kurisu K (35人中5番目)
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 61 Issue: 12 Pages: 675-710

    • DOI

      10.2176/nmc.st.2021-0254

    • NAID

      130008129596

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive astrocytes contribute to epileptogenesis in patients with cavernous angioma2021

    • Author(s)
      Kitaura H, Hiraishi T, Itoh Y, Oishi M, Fujii Y, Fukuda M, Kakita A.
    • Journal Title

      Epilepsy Res

      Volume: 176 Pages: 106732-106732

    • DOI

      10.1016/j.eplepsyres.2021.106732

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study2021

    • Author(s)
      Mizobuchi Y, Nagahiro S, Kondo A, Arita K, Date I, Fujii Y, Fujimaki T, Hanaya R, Hasegawa M, Hatayama T, Inoue T, Kasuya H, Kobayashi M, Kohmura E, Matsushima T, Masuoka J, Morita A, Nishizawa S, Okayama Y, Shigeno T, Shimano H, Takeshima H, Yamakami I.
    • Journal Title

      Neurosurgery

      Volume: 89 Issue: 4 Pages: 557-564

    • DOI

      10.1093/neuros/nyab229

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Less-invasive diagnosis of disseminated epithelioid glioblastoma harboring BRAF V600E mutation by cerebrospinal fluid analysis-A case report2021

    • Author(s)
      Natsumeda M, Kanemaru Y, Kawaguchi Y, Umezu H, Kakita A, Fujii Y.
    • Journal Title

      Clin Case Rep

      Volume: 9 Issue: 7

    • DOI

      10.1002/ccr3.4551

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predicting BRAF V600E mutation in glioblastoma: utility of radiographic features2021

    • Author(s)
      Natsumeda M, Chang M, Gabdulkhaev R, Takahashi H, Tsukamoto Y, Kanemaru Y, Okada M, Oishi M, Okamoto K, Rodriguez FJ, Kakita A, Fujii Y, Schreck KC.
    • Journal Title

      Brain Tumor Pathol

      Volume: 38 Issue: 3 Pages: 228-233

    • DOI

      10.1007/s10014-021-00407-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Low Detection Rate of H3K27M Mutations in Cerebrospinal Fluid Obtained from Lumbar Puncture in Newly Diagnosed Diffuse Midline Gliomas2021

    • Author(s)
      On Jotaro、Natsumeda Manabu、Watanabe Jun、Saito Shoji、Kanemaru Yu、Abe Hideaki、Tsukamoto Yoshihiro、Okada Masayasu、Oishi Makoto、Yoshimura Junichi、Kakita Akiyoshi、Fujii Yukihiko
    • Journal Title

      Diagnostics

      Volume: 11 Issue: 4 Pages: 681-681

    • DOI

      10.3390/diagnostics11040681

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates2021

    • Author(s)
      Okada Masayasu、Kawagoe Yosuke、Sato Yuta、Nozumi Motohiro、Ishikawa Yuya、Tamada Atsushi、Yamazaki Hiroyuki、Sekino Yuko、Kanemura Yonehiro、Shinmyo Yohei、Kawasaki Hiroshi、Kaneko Naoko、Sawamoto Kazunobu、Fujii Yukihiko、Igarashi Michihiro
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s13041-021-00755-0

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children’s Cancer Group2021

    • Author(s)
      Miyahara Hiroaki、Natsumeda Manabu、Kanemura Yonehiro、Yamasaki Kai、Riku Yuichi、Akagi Akio、Oohashi Wataru、Shofuda Tomoko、Yoshioka Ema、Sato Yuya、Taga Takashi、Naruke Yuki、Ando Ryo、Hasegawa Daiichiro、Yoshida Makiko、Sakaida Tsukasa、Okada Naoki、Watanabe Hiroyoshi、Ozeki Michio、Fujii Yukihiko、et al.
    • Journal Title

      Brain Tumor Pathology

      Volume: 38 Issue: 3 Pages: 109-121

    • DOI

      10.1007/s10014-021-00396-0

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Delayed Bleeding of Unruptured Intracranial Aneurysms After Coil Embolization: A Retrospective Case Series2021

    • Author(s)
      Ando K, Hasegawa H, Suzuki T, Saito S, Shibuya K, Takahashi H, Oishi M, Fujii Y.
    • Journal Title

      World Neurosurg

      Volume: 149 Pages: e135-e145

    • DOI

      10.1016/j.wneu.2021.02.061

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hemodynamic features of an intracranial aneurysm rupture predicted by perianeurysmal edema: A case report2021

    • Author(s)
      Suzuki Tomoaki、Hasegawa Hitoshi、Ando Kazuhiro、Shibuya Kohei、Takahashi Haruhiko、Saito Shoji、On Jotaro、Oishi Makoto、Fujii Yukihiko
    • Journal Title

      Surgical Neurology International

      Volume: 12 Pages: 49-49

    • DOI

      10.25259/sni_780_2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective, Multicenter Clinical Study of Microvascular Decompression for Hemifacial Spasm2021

    • Author(s)
      Mizobuchi Yoshifumi、Nagahiro Shinji、Kondo Akinori、Arita Kazunori、Date Isao、Fujii Yukihiko、et al.
    • Journal Title

      Neurosurgery

      Volume: 88 Issue: 4 Pages: 846-854

    • DOI

      10.1093/neuros/nyaa549

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] GLI3?Is Associated With Neuronal Differentiation in SHH-Activated and WNT-Activated Medulloblastoma2021

    • Author(s)
      Natsumeda Manabu、Miyahara Hiroaki、Yoshimura Junichi、Nakata Satoshi、Tsukamoto Yoshihiro、Okada Masayasu、Oishi Makoto、Hirato Junko、Wataya Takafumi、Tateishi Kensuk、Rodriguez Fausto J、Hovestadt Volker、Suva Mario L、Taylor Michael D、Eberhart Charles G、Fujii Yukihiko、et al.
    • Journal Title

      Journal of Neuropathology & Experimental Neurology

      Volume: 80 Issue: 2 Pages: 129-136

    • DOI

      10.1093/jnen/nlaa141

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Four-dimensional multifusion imaging for assessment of meningioma hemodynamics2021

    • Author(s)
      Ogura Ryosuke、Oishi Makoto、Hiraishi Tetsuya、Takahashi Haruhiko、Shibuya Kohei、Suzuki Tomoaki、Natsumeda Manabu、Okamoto Kouichirou、Fujii Yukihiko
    • Journal Title

      Interdisciplinary Neurosurgery

      Volume: 24 Pages: 101118-101118

    • DOI

      10.1016/j.inat.2021.101118

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possibility of Worsening Flow Diversion Effect Due to Morphological Changes of a Stented Artery With Multiple Overlapping Stents for Partially Thrombosed Vertebral Artery Aneurysms2020

    • Author(s)
      Suzuki Tomoaki、Hasegawa Hitoshi、Ando Kazuhiro、Shibuya Kouhei、Takahashi Haruhiko、Saito Shoji、Oishi Makoto、Fujii Yukihiko
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 611124-611124

    • DOI

      10.3389/fneur.2020.611124

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteomic profile differentiating between mesial temporal lobe epilepsy with and without hippocampal sclerosis2020

    • Author(s)
      Furukawa Ayako、Kakita Akiyoshi、Chiba Yoichi、Kitaura Hiroki、Fujii Yukihiko、Fukuda Masafumi、Kameyama Shigeki、Shimada Atsuyoshi
    • Journal Title

      Epilepsy Research

      Volume: 168 Pages: 106502-106502

    • DOI

      10.1016/j.eplepsyres.2020.106502

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unilateral oculomotor nerve palsy caused by arterial compression accompanying subarachnoid hemorrhage: a case report2020

    • Author(s)
      Saito Shoji、Hasegawa Hitoshi、Takino Toru、Ando Kazuhiro、Shibuya Kohei、Takahashi Haruhiko、On Jotaro、Suzuki Tomoaki、Oishi Makoto、Fujii Yukihiko
    • Journal Title

      Acta Neurochirurgica

      Volume: 163 Issue: 3 Pages: 813-816

    • DOI

      10.1007/s00701-020-04633-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular Features and Prognostic Factors of Pleomorphic Xanthoastrocytoma: A Collaborative Investigation of the Tohoku Brain Tumor Study Group2020

    • Author(s)
      ONO Takahiro、SASAJIMA Toshio、SHIMIZU Hiroaki、NATSUMEDA Manabu、KANAMORI Masayuki、ASANO Kenichiro、BEPPU Takaaki、MATSUDA Kenichiro、ICHIKAWA Masahiro、FUJII Yukihiko、et al.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 60 Issue: 11 Pages: 543-552

    • DOI

      10.2176/nmc.oa.2020-0155

    • NAID

      130007939878

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma2020

    • Author(s)
      Tateishi Kensuke、Miyake Yohei、Kawazu Masahito、Sasaki Nobuyoshi、Nakamura Taishi、Sasame Jo、Yoshii Yukie、Ueno Toshihide、Miyake Akio、Matsushita Yuko、Shiba Norio、Udaka Naoko、Ohki Kentaro、Fink Alexandria L.、Tummala Shilpa S.、Natsumeda Manabu、Miller Julie J.、Fujii Yukihiko、et al
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 23 Pages: 5330-5343

    • DOI

      10.1158/0008-5472.can-20-2425

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Safety and feasibility of the distal transradial approach: A novel technique for diagnostic cerebral angiography2020

    • Author(s)
      Saito Shoji、Hasegawa Hitoshi、Ota Tomoyoshi、Takino Toru、Yoshida Yuichi、Ando Kazuhiro、Shibuya Kohei、Takahashi Haruhiko、Suzuki Tomoaki、Oishi Makoto、Fujii Yukihiko
    • Journal Title

      Interventional Neuroradiology

      Volume: 26 Issue: 6 Pages: 713-718

    • DOI

      10.1177/1591019920925709

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Japan Neurosurgical Database: Overview and Results of the First-year Survey2020

    • Author(s)
      IIHARA Koji、TOMINAGA Teiji、SAITO Nobuhito、SUZUKI Michiyasu、DATE Isao、FUJII Yukihiko、et al
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 60 Issue: 4 Pages: 165-190

    • DOI

      10.2176/nmc.st.2019-0211

    • NAID

      130007832497

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of the ghrelin/growth hormone secretagogue receptor axis and its functional role in promoting tumor growth in primary central nervous system lymphomas2020

    • Author(s)
      Muta Hiroko、Sugita Yasuo、Furuta Takuya、Shiimura Yuki、Ohshima Koichi、Nakashima Kazutaka、Sato Kensaku、Morioka Motohiro、Abe Hideyuki、Nozawa Takanori、Fujii Yukihiko、Kakita Akiyoshi
    • Journal Title

      Neuropathology

      Volume: - Issue: 3 Pages: 232-239

    • DOI

      10.1111/neup.12634

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corrigendum to 'Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events' [World Neurosurgery 130 (2019) e251-e258]2020

    • Author(s)
      Hasegawa Mitsuhiro、Hatayama Toru、Kondo Akinori、Nagahiro Shinji、Fujimaki Takamitsu、Amagasaki Kenichi、Arita Kazunori、Date Isao、Fujii Yukihiko、et al
    • Journal Title

      World Neurosurgery

      Volume: 134 Pages: 685-685

    • DOI

      10.1016/j.wneu.2019.10.081

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vascular Hyperintensity on Fluid-Attenuated Inversion Recovery Indicates the Severity of Hypoperfusion in Acute Stroke2020

    • Author(s)
      Nomura Toshiharu、Okamoto Kouichirou、Igarashi Hironaka、Watanabe Masato、Hasegawa Hitoshi、Oishi Makoto、Fujii Yukihiko
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 29 Issue: 2 Pages: 104467-104467

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.104467

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Quality Indicators of Stroke Centers and Feasibility of Their Measurement Using a Nationwide Insurance Claims Database in Japan ― J-ASPECT Study ―2019

    • Author(s)
      Hasegawa M、Hatayama T、Kondo A、Nagahiro S、Fujimaki T、Amagasaki K、Arita K、Date I、Fujii Y、et al
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 11 Pages: 2292-2302

    • DOI

      10.1253/circj.CJ-19-0089

    • NAID

      130007733307

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-10-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 症例 Posterior quadrantectomyが有効であった難治性てんかんの乳児例2019

    • Author(s)
      Saito T, Oishi M, Fukuda M, Tsukamoto Y, Ohashi T, Watanabe J, Nemoto T,Kawaguchi T, Fujii Y.
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 47 Issue: 3 Pages: 349-356

    • DOI

      10.11477/mf.1436203943

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2019-03-10
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas2019

    • Author(s)
      Hideaki Abe, Manabu Natsumeda1, Masayasu Okada, Jun Watanabe, Yoshihiro Tsukamoto, Yu Kanemaru, Junichi Yoshimura, Makoto Oishi, Rintaro Hashizume, Akiyoshi Kakita and Yukihiko Fujii
    • Journal Title

      Frontiers in Oncology

      Volume: 9 Pages: 1-10

    • DOI

      10.3389/fonc.2019.01568

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Determining if Cerebrospinal Fluid Prevents Recurrence of Chronic Subdural Hematoma: A Multi-Center Prospective Randomized Clinical Trial.2019

    • Author(s)
      Toi H, Fujii Y, Iwama T, Kinouchi H, Nakase H, Nozaki K, Ohkuma H, Ohta H, Takeshima H, Tokumasu H, Yoshimoto Y, Uno M.
    • Journal Title

      J Neurotrauma

      Volume: 36 Issue: 4 Pages: 559-564

    • DOI

      10.1089/neu.2018.5821

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] EGFRvIII Is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma2019

    • Author(s)
      Nozawa T , Okada M, Natsumeda M, Eda T, Abe H, Tsukamoto Y, Okamoto K, Oishi M, Takahashi H, Fujii Y, Kakita A
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 59 Issue: 3 Pages: 89-97

    • DOI

      10.2176/nmc.oa.2018-0078

    • NAID

      130007612662

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiplex ligation-dependent probe amplification analysis is useful for detecting a copy number gain of the FGFR1 tyrosine kinase domain in dysembryoplastic neuroepithelial tumors.2019

    • Author(s)
      Matsumura N, Nobusawa S, Ito J, Kakita A, Suzuki H, Fujii Y, Fukuda M, Iwasaki M, Nakasato N, Tominaga T, Natsume A, Mikami Y, Shinojima N, Yamazaki T, Nakazato Y, Hirato J, Yokoo H.
    • Journal Title

      J Neurooncol.

      Volume: 143 Issue: 1 Pages: 27-33

    • DOI

      10.1007/s11060-019-03138-7

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decreased wall shear stress at high-pressure areas predicts the rupture point in ruptured intracranial aneurysms.2019

    • Author(s)
      Suzuki T, Stapleton CJ, Koch MJ, Tanaka K, Fujimura S, Suzuki T, Yanagisawa T,Yamamoto M, Fujii Y, Murayama Y, Patel AB.
    • Journal Title

      J Neurosurg.

      Volume: 印刷中 Issue: 4 Pages: 1-7

    • DOI

      10.3171/2018.12.jns182897

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Noninvasive Vagus Nerve Stimulation Prevents Ruptures and Improves Outcomes in a Model of Intracranial Aneurysm in Mice.2019

    • Author(s)
      Suzuki T, Takizawa T, Kamio Y, Qin T, Hashimoto T, Fujii Y, Murayama Y, Patel AB, Ayata C.
    • Journal Title

      Stroke

      Volume: 50 Issue: 5 Pages: 1216-1223

    • DOI

      10.1161/strokeaha.118.023928

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Malignant hyperthermia and cerebral venous sinus thrombosis following ventriculoperitoneal shunt in an infant with schizencephaly and COL4A1 mutation.2019

    • Author(s)
      Watanabe J, Okamoto K, Ohashi T, Natsumeda M, Hasegawa H, Oishi M, Miyatake S,Matsumoto N, Fujii Y.
    • Journal Title

      World Neurosurg.

      Volume: 印刷中 Pages: 446-450

    • DOI

      10.1016/j.wneu.2019.04.156

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Podoplanin expression and IDH-wildtype status predicts venous thromboembolism in patients with high-grade gliomas in the early postoperative period.2019

    • Author(s)
      Watanabe J, Natsumeda M, Okada M, Kanemaru Y, Tsukamoto Y, Oishi M, Kakita A, Fujii Y.
    • Journal Title

      World Neurosurg.

      Volume: 印刷中 Pages: 2275-2281

    • DOI

      10.1016/j.wneu.2019.05.049

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prosthesis Used in Microvascular Decompressions: A Multicenter Survey in Japan Focusing on Adverse Events2019

    • Author(s)
      Hasegawa M, Hatayama T, Kondo A, Nagahiro S, Fujimaki T, Amagasaki K, Arita K, Date I, Fujii Y, et al
    • Journal Title

      World Neurosurgery

      Volume: 130 Pages: e251-e258

    • DOI

      10.1016/j.wneu.2019.06.053

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment Strategies for Infectious Intracranial Aneurysms: Report of Three Cases and Review of the Literature2019

    • Author(s)
      ANDO Kazuhiro、HASEGAWA Hitoshi、KIKUCHI Bumpei、SAITO Shoji、ON Jotaro、SHIBUYA Kohei、FUJII Yukihiko
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 59 Issue: 9 Pages: 344-350

    • DOI

      10.2176/nmc.oa.2019-0051

    • NAID

      130007706967

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of circulating tumor DNA between body fluids in patients with primary central nervous system lymphoma2019

    • Author(s)
      Watanabe Jun、Natsumeda Manabu、Kanemaru Yu、Okada Masayasu、Oishi Makoto、Kakita Akiyoshi、Fujii Yukihiko
    • Journal Title

      Leukemia & Lymphoma

      Volume: 60 Issue: 14 Pages: 3587-3589

    • DOI

      10.1080/10428194.2019.1639169

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy2019

    • Author(s)
      Kanemaru Yu、Natsumeda Manabu、Okada Masayasu、Saito Rie、Kobayashi Daiki、Eda Takeyoshi、Watanabe Jun、Saito Shoji、Tsukamoto Yoshihiro、Oishi Makoto、Saito Hirotake、Nagahashi Masayuki、Sasaki Takahiro、Hashizume Rintaro、Aoyama Hidefumi、Wakai Toshifumi、Kakita Akiyoshi、Fujii Yukihiko
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 7 Issue: 1 Pages: 119-119

    • DOI

      10.1186/s40478-019-0774-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <i>De Novo</i> Pineal Region Germinoma in the Seventh Decade of Life: A Case Report2019

    • Author(s)
      Sano Masakazu、Jinguji Shinya、Yoshimura Junichi、Okamoto Kouichirou、Fujii Yukihiko
    • Journal Title

      NMC Case Report Journal

      Volume: 6 Issue: 3 Pages: 75-78

    • DOI

      10.2176/nmccrj.cr.2018-0221

    • NAID

      130007673060

    • ISSN
      2188-4226
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] ICH Growth Individual Patient Data Meta-analysis Collaborators. Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.2019

    • Author(s)
      Al-Shahi Salman R, Frantzias J, Lee RJ, Lyden PD, et al(著者67人中、Oish Mは14番目、Fujii Yは64番目)
    • Journal Title

      Lancet Neurol.

      Volume: 17 Issue: 10 Pages: 885-894

    • DOI

      10.1016/s1474-4422(18)30253-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detecting intertrochanteric hip fractures with orthopedist-level accuracy using a deep convolutional neural network.2019

    • Author(s)
      Urakawa T, Tanaka Y, Goto S, Matsuzawa H, Watanabe K, Endo N
    • Journal Title

      Skeletal Radiol.

      Volume: 48 Issue: 2 Pages: 239-244

    • DOI

      10.1007/s00256-018-3016-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The perivascular microenvironment in Epstein-Barr virus positive primary central nervous system lymphoma: The role of programmed cell death 1 and programmed cell death ligand 1.2018

    • Author(s)
      Sugita Y, Furuta T, Ohshima K, Komaki S, Miyoshi J, Morioka M, Abe H, Nozawa T, Fujii Y, Takahashi H, Kakita A.
    • Journal Title

      Neuropathology

      Volume: 38 Issue: 2 Pages: 125-134

    • DOI

      10.1111/neup.12435

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Has acromegaly been diagnosed earlier?2018

    • Author(s)
      Ohno H, Yoneoka Y, Jinguji S, Watanabe N, Okada M, Fujii Y.
    • Journal Title

      J Clin Neurosci

      Volume: 48 Pages: 138-142

    • DOI

      10.1016/j.jocn.2017.10.086

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathophysiological characteristics associated with epileptogenesis in Human Hippocampal sclerosis.2018

    • Author(s)
      Kitaura H, Shirozu H, Masuda H, Fukuda M, Fujii Y, Kakita A
    • Journal Title

      EBioMedicine

      Volume: 29 Pages: 38-46

    • DOI

      10.1016/j.ebiom.2018.02.013

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.2018

    • Author(s)
      Natsumeda M, Motohashi K, Igarashi H, Nozawa T, Abe H, Tsukamoto Y, Ogura R, Okada M, Kobayashi T, Aoki H, Takahashi H, Kakita A, Okamoto K, Nakada T, Fujii Y.
    • Journal Title

      Neurosurg Rev

      Volume: 41 Issue: 2 Pages: 641-647

    • DOI

      10.1007/s10143-017-0908-y

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High Incidence of Deep Vein Thrombosis in the Perioperative Period of Neurosurgical Patients.2018

    • Author(s)
      Natsumeda M, Uzuka T, Watanabe J, Fukuda M, Akaiwa Y, Hanzawa K, Okada M, Oishi M, Fujii Y.
    • Journal Title

      World Neurosurg

      Volume: 112 Pages: e103-e112

    • DOI

      10.1016/j.wneu.2017.12.139

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Advances and challenges in assessing 2-hydroxyglutarate in gliomas by magnetic resonance spectroscopy: a short review.2018

    • Author(s)
      Natsumeda M, Igarashi H, Motohashi K, Suzuki Y, Ohkubo M, Okamoto K, Watanabe M, Nakada T, Fujii Y.
    • Journal Title

      Neuropsychiatry (London)

      Volume: 8 Pages: 1831-1838

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration.2018

    • Author(s)
      Okada M*, Kawasaki A*, Tamada A*, Okuda S, Nozumi M, Ito Y, Kobayashi D, Yamasaki T, Yokoyama R, Shibata T, Nishina H, Yoshida Y, Fujii Y, Takeuchi K, Igarashi M(*These three authorscontributed equally.).
    • Journal Title

      ISCIENCE

      Volume: 4 Pages: 190-203

    • DOI

      10.1016/j.isci.2018.05.019

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polysomnography as an indicator for cervicomedullary decompression to treat foramen magnum stenosis in achondroplasia.2018

    • Author(s)
      Sano M, Takahashi N, Nagasaki K, Oishi M, Yoshimura J, Fujii Y.
    • Journal Title

      Child’s Nervous System

      Volume: 34 Issue: 11 Pages: 2275-2281

    • DOI

      10.1007/s00381-018-3880-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas2018

    • Author(s)
      Hideaki Abe, Manabu Natsumeda, Yu Kanemaru, Jun Watanabe, Yoshihiro Tsukamoto, Masayasu Okada, Junichi Yoshimura, Makoto Oishi, Yukihiko Fujii
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 58 Issue: 7 Pages: 290-295

    • DOI

      10.2176/nmc.ra.2018-0044

    • NAID

      130007405002

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aquaporin PET differentiates between grade III and IV human astrocytoma.2018

    • Author(s)
      Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H, Kitaura H, Kakita A, Fujii Y, Huber VJ, Igarashi H, Kwee IL, Nakada T
    • Journal Title

      Neurosurgery

      Volume: 印刷中 Issue: 6 Pages: 842-846

    • DOI

      10.1093/neuros/nyx314

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy2018

    • Author(s)
      Ishiura Hiroyuki、Doi Koichiro、Mitsui Jun、Yoshimura Jun、Matsukawa Miho Kawabe、Takahashi Yuji、Date Hidetoshi、Matsukawa Takashi、Shimizu Jun、Koh Kishin、Takiyama Yoshihisa、Goto Jun、Morishita Shinichi、Tsuji Shoji
    • Journal Title

      Nature Genetics

      Volume: 50 Issue: 4 Pages: 581-590

    • DOI

      10.1038/s41588-018-0067-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biallelic Variants in CNPY3 , Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy2018

    • Author(s)
      Mutoh Hiroki、Kato Mitsuhiro、Akita Tenpei、Shibata Takuma、Wakamoto Hiroyuki、Ikeda Hiroko、Kitaura Hiroki、Aoto Kazushi、Nakashima Mitsuko、Wang Tianying、Ohba Chihiro、Miyatake Satoko、Miyake Noriko、Kakita Akiyoshi、Miyake Kensuke、Fukuda Atsuo、Matsumoto Naomichi、Saitsu Hirotomo
    • Journal Title

      The American Journal of Human Genetics

      Volume: 102 Issue: 2 Pages: 321-329

    • DOI

      10.1016/j.ajhg.2018.01.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adult Chiari Type 1 Malformation with Holocord Syringomyelia Associated with Sagittal Synostosis2018

    • Author(s)
      Sano M, Yoshimura J, Fujii Y
    • Journal Title

      NMC Case Report Journal

      Volume: 5 Issue: 1 Pages: 27-30

    • DOI

      10.2176/nmccrj.cr.2017-0013

    • NAID

      130006301795

    • ISSN
      2188-4226
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical magnetic resonance microscopy anatomic analysis on a 7 T system.2018

    • Author(s)
      Kwee IL, Matsuzawa H, Nakada K, Fujii Y, Nakada T.
    • Journal Title

      SAGE Open Med Case Rep

      Volume: 5 Pages: 1-4

    • DOI

      10.1177/2050313x17745209

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.2018

    • Author(s)
      Yoneoka Y, Yoshimura J, Sano M, Okada M, Kakita A, Fujii Y.
    • Journal Title

      Pediatr Neurosurg

      Volume: 53 Issue: 1 Pages: 49-54

    • DOI

      10.1159/000480021

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Additional resective surgery after the failure of initial surgery in patients with intractable epilepsy.2017

    • Author(s)
      Fukuda M, Masuda H, Shirozu H, Ito Y, Nakayama Y, Higashijima T, Fujii Y.
    • Journal Title

      Neurol Res

      Volume: 39 Issue: 12 Pages: 1049-1055

    • DOI

      10.1080/01616412.2017.1376471

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: An MRI volumetric and histopathological study.2017

    • Author(s)
      Nakayama Y, Masuda H, Shirozu H, Ito Y, Higashijima T, Kitaura H, Fujii Y, Kakita A, Fukuda M.
    • Journal Title

      Epilepsy Res

      Volume: 135 Pages: 50-55

    • DOI

      10.1016/j.eplepsyres.2017.05.010

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 神経科学に新たな展開をもたらす imaging treatment2022

    • Author(s)
      藤井幸彦
    • Organizer
      第45回日本脳神経CI学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] あすを創る人材育成:変わらなければならないもの、変わってはならないもの2022

    • Author(s)
      藤井幸彦
    • Organizer
      第61回日本定位・機能神経外科学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ヒト神経細胞成長マーカーの同定2021

    • Author(s)
      岡田正康、金子奈穂子、山崎博幸、棗田 学、大石 誠、金村米博、澤本和延、藤井幸彦、五十嵐道弘
    • Organizer
      日本脳神経外科学会第 80 回学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 外科治療を見据えたてんかん薬物治療2021

    • Author(s)
      福多真史、藤井幸彦、他
    • Organizer
      第44 回日本てんかん外科学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 高次脳機能障害と運転2019

    • Author(s)
      藤井幸彦
    • Organizer
      日本学術会議(学術フォーラム)自動車の自動運転の推進と社会的課題について―移動の本能と新しい社会のデザイン-
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 脳外科診療に役立つ凝血学的知見2019

    • Author(s)
      藤井幸彦
    • Organizer
      北関東脊髄外科研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 脳卒中医療のための凝血学的スキルアップ2019

    • Author(s)
      藤井幸彦
    • Organizer
      脳卒中医療のためのスキルアップセミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 脳梗塞の予防・治療のUpdate-外科的アプローチ-2019

    • Author(s)
      藤井幸彦
    • Organizer
      新潟県医師会学術講演会:上越地区
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 小児内側側頭葉てんかんの長期術後発作転帰2019

    • Author(s)
      増田浩、白水洋史、伊藤陽祐、村井志乃、福多真史、藤井幸彦
    • Organizer
      第53回日本てんかん学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Neurite orientation dispersion and density imaging による皮質形成異常の可視化2019

    • Author(s)
      伊藤陽祐、松澤等、福多真史、増田浩、白水洋史、村井志乃、 北浦弘樹、柿田明美、藤井幸彦
    • Organizer
      第53回日本てんかん学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Long-term epilepsy-associated tumor の術後長期予後2019

    • Author(s)
      福多真史、増田浩、白水洋史、伊藤陽祐、村井志乃、藤井幸彦、 北浦弘樹、柿田明美
    • Organizer
      第53回日本てんかん学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] てんかん外科治療後の抗てんかん薬の断薬についての検討2019

    • Author(s)
      増田浩、藤井幸彦
    • Organizer
      第43回日本てんかん外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 難治性てんかんに対する迷走神経刺激療法後のベンゾジアゼピン受容体の変化-迷走神経刺激療法の作用機序の考察-2019

    • Author(s)
      福多真史、増田浩、白水洋史、伊藤陽祐、村井志乃、藤井幸彦
    • Organizer
      日本脳神経外科学会第78回学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] NODDIによる皮質形成異常の可視化2019

    • Author(s)
      福多真史、増田浩、白水洋史、伊藤陽祐、村井志乃、藤井幸彦
    • Organizer
      日本脳神経外科学会第78回学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] GPi-DBSが有効であった最重度発達遅滞を伴う舞踏アテトーゼの1例2019

    • Author(s)
      東島威史、福多真史、増田浩、白水洋史、伊藤陽祐、村井志乃、藤井幸彦
    • Organizer
      日本脳神経外科学会第78回学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 苦手意識をなくそう!てんかん発作を救急で見分ける2018

    • Author(s)
      大石 誠
    • Organizer
      研修医神経救急パワーアップセミナー(長岡市)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脳神経外疾患の治療戦略に役立つ凝固線溶2018

    • Author(s)
      藤井幸彦
    • Organizer
      第1回東毛地区有壬会(太田市)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 最新脳外科診療2018

    • Author(s)
      藤井幸彦
    • Organizer
      柏崎総合医療センター院内講演(柏崎市)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脳梗塞の予防・治療の Update-外科的アプローチ-2018

    • Author(s)
      藤井幸彦
    • Organizer
      新潟県医師会学術講演会(新潟市)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Temozolomide and Notch inhibitor MRK-003 induce cell protective autophagy in malignant gliomas2018

    • Author(s)
      Natsumeda M, Fujii Y
    • Organizer
      第19回国際神経病理学会(東京都)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 7-tesla MR susceptibility-weighted imaging can depict astrocytic and oligodendroglial pathology2018

    • Author(s)
      棗田 学, 藤井幸彦
    • Organizer
      第36回日本脳腫瘍病理学会(東京都)
    • Related Report
      2018 Research-status Report
  • [Presentation] The Growth Cone phosphoproteomics reveals an Axonal Regeneration Marker(Poster or talk)2018

    • Author(s)
      岡田正康、藤井幸彦
    • Organizer
      Cold Spring Harbor Asia Conference(淡路市)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Developing models for translational research on pediatric brain tumors2018

    • Author(s)
      Natsumeda M, Fujii Y
    • Organizer
      第5回国際脳腫瘍病理シンポジウム(熱海市)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The Current Situation and Prospects of Clinical High-resolution MR Imaging (Lecture for neurosurgeon)2018

    • Author(s)
      Fujii Y
    • Organizer
      Seoul National University Lecture(Seoul)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism of cortical motor reorganization (Lecture for gradual students )2018

    • Author(s)
      Fujii Y
    • Organizer
      Seoul National University Lecture(Seoul)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 治療戦略に役立つ臨床研究ー詳細画像と血液凝固を中心にー2018

    • Author(s)
      藤井幸彦
    • Organizer
      第26回河田町脳神経外科懇話会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 治療戦略に役立つニューロイメージング2017

    • Author(s)
      藤井幸彦
    • Organizer
      長崎大学脳神経外科同門会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 身近な疾患に対する最新脳外科診療2017

    • Author(s)
      藤井幸彦
    • Organizer
      新潟地域医療講演会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2023-01-30  

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