Visualization of epileptogenic foci of MRI non-lesional neocortical epilepsy patients by 7T-MRI
Project/Area Number |
17K10888
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
福多 真史 新潟大学, 脳研究所, 非常勤講師 (00361907)
大石 誠 新潟大学, 脳研究所, 准教授 (00422593)
松澤 等 新潟大学, 脳研究所, 非常勤講師 (70303170)
柿田 明美 新潟大学, 脳研究所, 教授 (80281012)
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Project Period (FY) |
2017-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | MRI陰性新皮質てんかん / 7テスラMRI / 機能的脳疾患 / 診療教育拠点 / 教育的診療教育拠点形成 / 教育的診療研究拠点形成 / 7テスラMRI |
Outline of Final Research Achievements |
This three-year prospective study was intended to visualize epileptogenic foci, as organic lesions, of non-lesional neocortical epilepsy patients by means of our imaging protocol including 7T-MRI and to understand the present status of these patients. However, the study was suspended for a long period because of mechanical failure of the 7T-MRI system, followed by the pandemic of coronavirus disease 2019 (COVID-19) pandemic. Therefore, the study period was finally extended to 5 years to catch up with our study schedule. Unfortunately, although 7T-MRI studies did not restart until the end of the study due to the protracted COVID-19 situation, we could obtain the following results: our imaging protocol could potentially visualize the epileptogenic foci of non-lesional neocortical epilepsy patients and provide insights into the present status of these patients.
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Academic Significance and Societal Importance of the Research Achievements |
この成果によって「MRI陰性新皮質てんかん」の器質的焦点の確実な切除が可能となり、発作を消失させることが期待できる。延いては、それにより全国に数万人存在すると予想される「MRI陰性新皮質てんかん」患者の発作を改善し、社会復帰させることが期待できる。てんかん発作に悩まされる患者自身および社会に齎される恩恵は計り知れない。またてんかんを始めとした機能的脳疾患に関わる高度専門医療人(医師、検査技師、看護師、等の医療職)養成、先進的診療実践、原因究明・新規治療法の開発等の高度研究の遂行を可能にする教育的診療研究拠点形成に向けたプロジェクトを前進させること出来た。
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Report
(6 results)
Research Products
(98 results)
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[Journal Article] HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E mutant high-grade glioma2022
Author(s)
Sasame J, Ikegaya N, Kawazu M, Natsumeda M, Hayashi T, Isoda M, Satomi K, Tomiyama A, Oshima A, Honma H, Miyake Y, Takabayashi K, Nakamura T, Ueno T, Matsushita Y, Iwashita H, Kanemaru Y, Murata H, Ryo A, Terashima K, Yamanaka S, Fujii Y, Mano H, Komori T, Ichimura K, Cahill DP, Wakimoto H, Yamamoto T, Tateishi K.
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Journal Title
Clin Cancer Res
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Issue: 11
Pages: 2425-2439
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[Journal Article] Clinicopathological risk factors for a poor prognosis of primary central nervous system lymphoma in elderly patients in the Tohoku and Niigata area: a multicenter, retrospective, cohort study of the Tohoku Brain Tumor Study Group2022
Author(s)
Asano K, Yamashita Y, Ono T, Natsumeda M, Beppu T, Matsuda K, Ichikawa M, Kanamori M, Matsuzaka M, Kurose A, Fumoto T, Saito K, Sonoda Y, Ogasawara K, Fujii Y, Shimizu H, Ohkuma H, Kitanaka C, Kayama T, Tominaga T.
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Journal Title
Brain Tumor Pathol
Volume: 印刷中
Issue: 3
Pages: 139-150
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[Journal Article] Novel Repositioning Therapy for Drug-Resistant Glioblastoma: In Vivo Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide2022
Author(s)
Eda T, Okada M, Ogura R, Tsukamoto Y, Kanemaru Y, Watanabe J, On J, Aoki H, Oishi M, Takei N, Fujii Y, Natsumeda M.
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Journal Title
Cancers (Basel)
Volume: 14
Issue: 3
Pages: 770-770
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[Journal Article] The Real-World status and risk factors for a poor prognosis in elderly patients with primary central nervous system malignant lymphomas: a multicenter, retrospective cohort study of the Tohoku Brain Tumor Study Group2022
Author(s)
Asano K, Yamashita Y, Ono T, Natsumeda M, Beppu T, Matsuda K, Ichikawa M, Kanamori M, Matsuzaka M, Kurose A, Saito K, Sonoda Y, Ogasawara K, Fujii Y, Shimizu H, Ohkuma H, Kitanaka C, Kayama T, Tominaga T.
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Journal Title
Int J Clin Oncol
Volume: 27
Issue: 1
Pages: 77-94
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[Journal Article] Endovascular treatment of an infectious aneurysm using the selective provocative test and transcranial motor evoked potential monitoring under general anesthesia: a case report2022
Author(s)
Ando K, Hiraishi T, Oishi M, Hasegawa H, Kikuchi B, Natsumeda M, Suzuki T, Saito S, Ota T, Yoshida Y, Fujii Y.
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Journal Title
Acta Neurochir (Wien)
Volume: 164
Issue: 5
Pages: 1265-1269
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[Journal Article] Detection of 2-Hydroxyglutarate by 3.0-Tesla Magnetic Resonance Spectroscopy in Gliomas with Rare IDH Mutations: Making Sense of "False-Positive" Cases2021
Author(s)
Natsumeda M, Igarashi H, Gabdulkhaev R, Takahashi H, Motohashi K, Ogura R, Watanabe J, Tsukamoto Y, Okamoto K, Kakita A, Nakada T, Fujii Y.
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Journal Title
Diagnostics (Basel)
Volume: 11
Issue: 11
Pages: 2129-2129
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[Journal Article] The Japan Neurosurgical Database: Statistics Update 2018 and 20192021
Author(s)
Iihara K, Saito N, Suzuki M, Date I, Fujii Y, Houkin K, Inoue T, Iwama T, Kawamata T, Kim P, Kinouchi H, Kishima H, Kohmura E, Kurisu K (35人中5番目)
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Journal Title
Neurologia medico-chirurgica
Volume: 61
Issue: 12
Pages: 675-710
DOI
NAID
ISSN
0470-8105, 1349-8029
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[Journal Article] Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study2021
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Mizobuchi Y, Nagahiro S, Kondo A, Arita K, Date I, Fujii Y, Fujimaki T, Hanaya R, Hasegawa M, Hatayama T, Inoue T, Kasuya H, Kobayashi M, Kohmura E, Matsushima T, Masuoka J, Morita A, Nishizawa S, Okayama Y, Shigeno T, Shimano H, Takeshima H, Yamakami I.
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Journal Title
Neurosurgery
Volume: 89
Issue: 4
Pages: 557-564
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[Journal Article] Predicting BRAF V600E mutation in glioblastoma: utility of radiographic features2021
Author(s)
Natsumeda M, Chang M, Gabdulkhaev R, Takahashi H, Tsukamoto Y, Kanemaru Y, Okada M, Oishi M, Okamoto K, Rodriguez FJ, Kakita A, Fujii Y, Schreck KC.
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Journal Title
Brain Tumor Pathol
Volume: 38
Issue: 3
Pages: 228-233
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[Journal Article] Determining if Cerebrospinal Fluid Prevents Recurrence of Chronic Subdural Hematoma: A Multi-Center Prospective Randomized Clinical Trial.2019
Author(s)
Toi H, Fujii Y, Iwama T, Kinouchi H, Nakase H, Nozaki K, Ohkuma H, Ohta H, Takeshima H, Tokumasu H, Yoshimoto Y, Uno M.
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Journal Title
J Neurotrauma
Volume: 36
Issue: 4
Pages: 559-564
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Related Report
Peer Reviewed
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[Journal Article] EGFRvIII Is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma2019
Author(s)
Nozawa T , Okada M, Natsumeda M, Eda T, Abe H, Tsukamoto Y, Okamoto K, Oishi M, Takahashi H, Fujii Y, Kakita A
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Journal Title
Neurologia medico-chirurgica
Volume: 59
Issue: 3
Pages: 89-97
DOI
NAID
ISSN
0470-8105, 1349-8029
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[Journal Article] Multiplex ligation-dependent probe amplification analysis is useful for detecting a copy number gain of the FGFR1 tyrosine kinase domain in dysembryoplastic neuroepithelial tumors.2019
Author(s)
Matsumura N, Nobusawa S, Ito J, Kakita A, Suzuki H, Fujii Y, Fukuda M, Iwasaki M, Nakasato N, Tominaga T, Natsume A, Mikami Y, Shinojima N, Yamazaki T, Nakazato Y, Hirato J, Yokoo H.
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Journal Title
J Neurooncol.
Volume: 143
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[Journal Article] Decreased wall shear stress at high-pressure areas predicts the rupture point in ruptured intracranial aneurysms.2019
Author(s)
Suzuki T, Stapleton CJ, Koch MJ, Tanaka K, Fujimura S, Suzuki T, Yanagisawa T,Yamamoto M, Fujii Y, Murayama Y, Patel AB.
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Journal Title
J Neurosurg.
Volume: 印刷中
Issue: 4
Pages: 1-7
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[Journal Article] The perivascular microenvironment in Epstein-Barr virus positive primary central nervous system lymphoma: The role of programmed cell death 1 and programmed cell death ligand 1.2018
Author(s)
Sugita Y, Furuta T, Ohshima K, Komaki S, Miyoshi J, Morioka M, Abe H, Nozawa T, Fujii Y, Takahashi H, Kakita A.
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Journal Title
Neuropathology
Volume: 38
Issue: 2
Pages: 125-134
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[Journal Article] Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.2018
Author(s)
Natsumeda M, Motohashi K, Igarashi H, Nozawa T, Abe H, Tsukamoto Y, Ogura R, Okada M, Kobayashi T, Aoki H, Takahashi H, Kakita A, Okamoto K, Nakada T, Fujii Y.
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Journal Title
Neurosurg Rev
Volume: 41
Issue: 2
Pages: 641-647
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[Journal Article] Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration.2018
Author(s)
Okada M*, Kawasaki A*, Tamada A*, Okuda S, Nozumi M, Ito Y, Kobayashi D, Yamasaki T, Yokoyama R, Shibata T, Nishina H, Yoshida Y, Fujii Y, Takeuchi K, Igarashi M(*These three authorscontributed equally.).
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ISCIENCE
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[Journal Article] Aquaporin PET differentiates between grade III and IV human astrocytoma.2018
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Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H, Kitaura H, Kakita A, Fujii Y, Huber VJ, Igarashi H, Kwee IL, Nakada T
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