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Combinational rehabilitation with epidural spinal cord stimulation and body weight support treadmill training for severe spinal cord injury model

Research Project

Project/Area Number 17K10922
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionChiba University

Principal Investigator

Murata Atushi  千葉大学, 医学部附属病院, 准教授 (20344997)

Co-Investigator(Kenkyū-buntansha) 古矢 丈雄  千葉大学, 医学部附属病院, 講師 (00507337)
國府田 正雄  筑波大学, 医学医療系, 准教授 (50361449)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脊髄損傷 / リハビリテーション / 脊髄電気刺激療法 / グルタミン酸脱炭酸酵素 / GAD65 / 胸髄
Outline of Final Research Achievements

We evaluated efficacy and molecular mechanism of spinal cord stimulation with treadmill training. In the spinal cord stimulation group, spasticity of hind-limb significantly reduced and histological assessment revealed that expression of GAD65 tended to increase. GAD65 is mainly found in membranes and nerve endings and may synthesize GABA for vesicular release. Therefore, upregulation of GAD65 is one of the possible mechanisms underlying the spinal cord stimulation induced attenuation of spasticity.

Academic Significance and Societal Importance of the Research Achievements

下肢の重度の運動感覚麻痺を伴う脊髄損傷患者に対し硬膜外電気刺激を行うことにより、下肢の随意運動が可能となることが報告されたが、その詳細なメカニズムは不明である。本研究では、重度脊髄損傷モデルラットの腰膨大部に硬膜外電気刺激を行い、行動学的、組織学的に有効性を検討した。組織学的検討においてグルタミン酸脱炭酸酵素GAD65の発現が高い傾向を示した。GAD65はリズミカルな歩行運動との関連が報告されている。GAD65は電気刺激による歩行機能再建の機序の1つであると考えられた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2017

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Combination of epidural spinal cord stimulation and body weight support treadmill training for severe spinal cord injury2017

    • Author(s)
      Jyunya Saito, Takeo Furuya, Masao Koda et al
    • Organizer
      The 35th Annual National Neurotrauma Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 硬膜外電気刺激と吊り下げ式免荷トレッドミルトレーニングを併用した重度脊髄損傷歩行再建の試み2017

    • Author(s)
      齊藤淳哉、古矢丈雄、國府田正雄 ほか
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 硬膜外電気刺激と吊り下げ式免荷トレッドミルトレーニングを併用した重度脊髄損傷歩行再建の試み2017

    • Author(s)
      齊藤淳哉、古矢丈雄、國府田正雄 ほか
    • Organizer
      第52回日本脊髄障害医学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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