| Project/Area Number |
17K11076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 脊髄 / 敗血症 / サイトカイン / ミクログリア / 神経炎症 / ミクリグリア / 麻酔科学 / 集中治療医学 |
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| Outline of Final Research Achievements |
Sepsis-induced inflammatory change in the brain has been precisely investigated, but in contrast, how sepsis influence the spinal cord remain unknown. We studied the inflammatory change induced by sepsis in the mice model, and found that as soon as several hours after LPS intraperitoneal injection, inflammaotry cytokines including IL-1b, IL-6 and TNF-a were drastically expressed in the spinal cord. Histological finding suggested that the resource of those cytokines are glial cells, especially microglia, nor peripheral blood cells. In addition, neuronal cells showed ischemic change concomittant with those inflammatory findings. Our finding suggest that sepsis induces significant inflammaotry reactions in the spinal cord, and those changes could be the cause of nurological dysfunctions.
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| Academic Significance and Societal Importance of the Research Achievements |
集中治療の進歩により、重症敗血症の生命予後自体は改善しつつあるが、一方で、治療後に運動機能が低下し、社会復帰できにくくなる病態（集中治療後症候群）が問題となっている。今回の研究によって、敗血症の際には、脊髄において強度の炎症性変化が起こりうること、またそれによって運動機能が障害される可能性が明らかとなった。今後敗血症治療を行う上で、脊髄は新しいターゲットとなりうると思われ、特に脊髄の炎症反応を担うグリア細胞、ミクログリアへの理解がさらに深まることが期待される。
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