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Prevention and treatment of postoperative cognitive dysfunction by regulating the expression of neurotrophic factors

Research Project

Project/Area Number 17K11080
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionKobe University

Principal Investigator

Obata Norihiko  神戸大学, 医学部附属病院, 助教 (30509443)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords術後認知機能障 / 神経栄養因子 / 術後認知機能障害 / 術後痛
Outline of Final Research Achievements

In this study, we investigated perioperative behavioral changes and various mRNA expression levels including neurotrophic factors in the brain using type 2 diabetes model mice.
Type 2 diabetes model mice were prepared by feeding a high fat diet. The behavior was evaluated by a series of protocols including an open field test, a novel object recognition test, and a light-dark box test. An open abdominal surgery was performed as a surgical invasion. After the behavioral experiment, brain tissues (frontal cortex) were collected and analyzed for mRNA expression levels of neurotrophic factors and catecholamine receptors using real-time PCR.
Postoperative activity decreased in type 2 diabetic model mice, suggesting that altered expression level of neurotrophic factors or catecholamines in the brain might be affecting.

Academic Significance and Societal Importance of the Research Achievements

高齢化社会が進む我が国において、高齢者に対する手術は急速に増加しており、術後認知機能障害は日々の臨床で重大な問題となっているが、その予防法や治療法は確立していない。本研究は術後認知機能障害のメカニズムとして脳における神経栄養因子やカテコラミンの関与に着目し、その発現を部位特異的に調節することで障害の予防と治療を目指すものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Suppression of behavioral activity and hippocampal noradrenaline caused by surgical stress in type 2 diabetes model mice2020

    • Author(s)
      Nishimura Momoka、Nomura Yuki、Egi Moritoki、Obata Norihiko、Tsunoda Makoto、Mizobuchi Satoshi
    • Journal Title

      BMC Neuroscience

      Volume: 21 Issue: 1 Pages: 1-10

    • DOI

      10.1186/s12868-020-0556-y

    • NAID

      120006813336

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 2型糖尿病マウスにおける術後低活動性と周術期脳内モノアミン受容体発現量の変化2019

    • Author(s)
      東南杏香、野村有紀、江木盛時、小幡典彦、溝渕知司
    • Organizer
      日本麻酔科学会第66回学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Postoperative Hypoactivities and Decrease of Hippocampal Catecholamine in Type 2 Diabetes Model Mice2019

    • Author(s)
      Momoka Nishimura, Yuki Nomural, Moritoki Egi, Norihiko obata, Makoto, Tsunoda, Satoshi Mizobuchi
    • Organizer
      American Society of Anesthesiologists Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2型糖尿病モデルマウスにおける術後低活動性および周術期脳内mRNA発現の変化2019

    • Author(s)
      東南杏香、野村有紀、江木盛時、小幡典彦、溝渕知司
    • Organizer
      日本麻酔科学会第66回学術集会
    • Related Report
      2018 Research-status Report
  • [Remarks] 神戸大学大学院医学研究科外科系講座麻酔科学ホームページ

    • URL

      http://www.med.kobe-u.ac.jp/anes/

    • Related Report
      2019 Annual Research Report 2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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