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Clinicopathological and molecular biological studies of RCCs based on WHO2016 classification

Research Project

Project/Area Number 17K11162
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionTokyo Women's Medical University

Principal Investigator

Nagashima Yoji  東京女子医科大学, 医学部, 教授 (10217995)

Co-Investigator(Kenkyū-buntansha) 近藤 恒徳  東京女子医科大学, 医学部, 教授 (50301544)
加藤 生真  横浜市立大学, 医学部, 助教 (80644939)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腎癌(腎細胞癌) / MiT転座型腎癌 / 透析関連腎癌 / フマル酸ヒドラターゼ欠損腎癌 / コハク酸脱水素酵素欠損腎癌 / 腎髄質癌 / 腎細胞癌 / 臨床病理学的研究 / MiT転座型腎細胞癌 / 透析関連腎細胞癌 / FH欠損性7腎細胞癌 / 嫌色素性腎細胞癌 / 予後因子 / 腎癌(腎細胞癌) / WHO2016分類 / MIT転座型腎細胞癌 / 後天性嚢胞腎随伴腎細胞癌 / HLRCC随伴腎細胞癌 / 腎腫瘍 / WHO分類 / MiT転座型 / HOCT / SDH欠損型腎細胞癌 / FH欠損型腎細胞癌 / Renal cell carcinoma / WHO2016 classification / Novel histological types
Outline of Final Research Achievements

We selected uncommon histological types (Mit-translocation type, dialysis-related or enzyme deficiency-associated) of renal cell carcinoma (RCC) in archval cases in our institute and consultation files, and analyzed clinicopathologically. We obtained the achievements, as follows; 1)MiT family translocation-associated RCC includes TFE3 translocation type. We identified that RBM10-TFE3 translocated cases are often associated with chroni kidney diseases. 2) We found the EWSR1 gene as a novel translocation partner of TFE3 gene. 3) We analyzed 10 patients with hereditary leiomyomatosis-RCC syndrome. Their RCC frequently showed positivity for PD-L1, which might present feasibility of immuno-oncological drugs as a therapeutic option. 4) Additionally, we report a very rare cases , i.e. mucinous tubular and spindle cell carcinoma, succnate dehydrogenase-deficient RCC, and medullary renal cell carcinoma with sickle cell trait. The medullary renal cell carcinoma is first report in Japan.

Academic Significance and Societal Importance of the Research Achievements

腎癌の頻度は必ずしも高くないが、多数の新規組織型がある。MiT転座型腎癌、酵素欠損性腎癌、透析関連腎癌などである。WHOでは2016年に最新の分類を出版した。本研究では腎癌新規組織型を多数例を検討し、本邦での臨床病理学的性質や組織型特異的なバイオマーカー、治療標的を明らかにした。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (93 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (36 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 30 results,  Open Access: 26 results) Presentation (49 results) (of which Int'l Joint Research: 2 results,  Invited: 10 results) Book (4 results) Remarks (3 results)

  • [Int'l Joint Research] チューリッヒ大学(スイス)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A case of high-grade mucinous tubular and spindle cell carcinoma2020

    • Author(s)
      Miura Koujin、Adachi Yasushi、Shirahase Toshiaki、Nagashima Yoji、Suemune Kazuki、Sakaida Noriko、Nakano Yorika、Sakai Yasuhiro、Shimizu Shigeki、Ikehara Susumu
    • Journal Title

      Journal of Surgical Case Reports

      Volume: 2020 Issue: 2

    • DOI

      10.1093/jscr/rjaa014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent pericardial effusion with pericardial amyloid deposition: a case report and literature review2020

    • Author(s)
      Itagaki Hiroko、Yamamoto Tomoko、Uto Kenta、Hiroi Atsuko、Onizuka Hiromi、Arashi Hiroyuki、Shibahashi Eiji、Isomura Shogo、Oda Hideaki、Yamashita Taro、Nagashima Yoji
    • Journal Title

      Cardiovascular Pathology

      Volume: 46 Pages: 107191-107191

    • DOI

      10.1016/j.carpath.2019.107191

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computed tomography imaging characteristics of clear cell papillary renal cell carcinoma2020

    • Author(s)
      Banno Taro、Takagi Toshio、Kondo Tsunenori、Yoshida Kazuhiko、Iizuka Junpei、Okumi Masayoshi、Ishida Hideki、Morita Satoru、Nagashima Yoji、Tanabe Kazunari
    • Journal Title

      International braz j urol

      Volume: 46 Issue: 1 Pages: 26-33

    • DOI

      10.1590/s1677-5538.ibju.2018.0716

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading2020

    • Author(s)
      Ohashi, R. Martignoni, G. Hartmann, A. Calio, A. Segala, D. Stohr, C. Wach, S. Erlmeier, F. Weichert, W. Autenrieth, M. Schraml, P. Rupp, N. J. Ohe, C. Otsuki, Y. Kawasaki, T. Kobayashi, H. Kobayashi, K. Miyazaki, T. Shibuya, H. Tsuzuki, T. Nagashima, Y. Ajioka, Y. Moch, H. et al.
    • Journal Title

      Virchows Arch

      Volume: 476 Issue: 3 Pages: 409-418

    • DOI

      10.1007/s00428-019-02710-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Classification of solid renal tumor with oncocytic/eosinophilic cytoplasm: is hybrid oncocytic/chromophobe renal tumor a subtype of oncocytoma, chromophobe renal cell carcinoma, or a distinct tumor entity?2019

    • Author(s)
      Mikami S, Kuroda N, Nagashima Y, Ohe C, Hayashi H, Mizuno R, Oya M, Kameyama K
    • Journal Title

      Annals of Transnational Medicine

      Volume: Suppl 8 Issue: S8 Pages: S350-S350

    • DOI

      10.21037/atm.2019.09.77

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Birt‐Hogg‐Dube syndrome‐associated renal cell carcinoma: Histopathological features and diagnostic conundrum2019

    • Author(s)
      Furuya M, Hasumi Y, Yao M, Nagashima Y.
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 1 Pages: 15-22

    • DOI

      10.1111/cas.14255

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Classic Chromophobe Renal Cell Carcinoma Incur a Larger Number of Chromosomal Losses Than Seen in the Eosinophilic Subtype2019

    • Author(s)
      Ohashi, R Schraml, P Angori, S Batavia, Aashil A Rupp, NJ Ohe, C Otsuki, Y Kawasaki, T Kobayashi, K Miyazaki, T Shibuya, H Nagashima, Y, Ajioka, Y, Moch, H et al.
    • Journal Title

      Cancers (Basel)

      Volume: 11 Issue: 10 Pages: 1492-1505

    • DOI

      10.3390/cancers11101492

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Malignant rhabdoid tumour in an adult kidney: A case report2019

    • Author(s)
      Okumura Yoshinaga、Adachi Yasushi、Shirahase Toshihiro、Nagashima Yoji、Tanaka Yukichi、Taki Yoji、Watanabe Jun、Uegaki Masayuki、Sakatani Toru、Ikehara Susumu
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 11 Pages: 55-58

    • DOI

      10.3892/mco.2019.1848

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease.2019

    • Author(s)
      Baba M, Furuya M, Motoshima T, Lang M, Funasaki S, Ma W, Sun HW, Hasumi H, Huang Y, Kato I, Kadomatsu T, Satou Y, Morris N, Karim BO, Ileva L, Kalen JD, Wilan Krisna LA, Hasumi Y, Sugiyama A, Kurahashi R, Nishimoto K, Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M, Kamba T, Suda T, Oike Y, Schmidt LS, Linehan WM
    • Journal Title

      Molecular Cancer Research

      Volume: 印刷中 Issue: 8 Pages: 1613-1626

    • DOI

      10.1158/1541-7786.mcr-18-1235

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RBM 10 ‐ TFE 3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break‐apart Fluorescence in situ Hybridization: Study of Ten Cases and a Literature Review2019

    • Author(s)
      Kato Ikuma、Furuya Mitsuko、Baba Masaya、Kameda Yoichi、Yasuda Masanori、Nishimoto Koshiro、Oyama Masafumi、Yamasaki Toshinari、Ogawa Osamu、Niino Hitoshi、Nakaigawa Noboru、Yano Yuta、Sakamoto Kazumasa、Urata Yoji、Mikami Kazuya、Yamasaki Shigetaka、Tanaka Reiko、Takagi Toshio、Kondo Tsunenori、Nagashima Yoji
    • Journal Title

      Histopathology

      Volume: 印刷中 Issue: 2 Pages: 254-265

    • DOI

      10.1111/his.13866

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal medullary carcinoma in a young mixed-race man in Japan2019

    • Author(s)
      Toriyama Akane、Izumi Hiroshi、Tomita Shigeki、Nagashima Yoji、Ueda Yoshihiko、Aoki Yusuke、Tsujimura Akira、Yao Takashi、Hino Okio
    • Journal Title

      Pathology International

      Volume: - Issue: 4 Pages: 241-245

    • DOI

      10.1111/pin.12783

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peritumoral pseudocapsule status according to pathological characteristics from robot‐assisted laparoscopic partial nephrectomy for localized renal cell carcinoma2019

    • Author(s)
      Takagi Toshio、Yoshida Kazuhiko、Kondo Tsunenori、Kobayashi Hirohito、Iizuka Junpei、Okumi Masayoshi、Ishida Hideki、Nagashima Yoji、Tanabe Kazunari
    • Journal Title

      International Journal of Urology

      Volume: 26 Issue: 4 Pages: 446-450

    • DOI

      10.1111/iju.13901

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease2019

    • Author(s)
      Baba M, Furuya M, Motoshima T, Lang M, Funasaki S, Ma W, Sun H-W, Dr. Hasumi H, Huang Y , Kato I , Kadomatsu T, Satou Y, Morris N , Karim BO, Ileva L , Kalen JD , Krisna LAW , Hasumi Y , Sugiyama A, Kurahashi R, Nishimoto K , Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M , Kamba T, Suda T , Oike Y, Schmidt LSS:
    • Journal Title

      Mol Cancer Res

      Volume: -

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel partner of TFE3 in the Xp11 translocation renal cell carcinoma: clinicopathological analyses and detection of EWSR1-TFE3 fusion2018

    • Author(s)
      Fukuda Hironori、Kato Ikuma、Furuya Mitsuko、Tanaka Reiko、Takagi Toshio、Kondo Tsunenori、Nagashima Yoji
    • Journal Title

      Virchows Archiv

      Volume: 474 Issue: 3 Pages: 389-393

    • DOI

      10.1007/s00428-018-2509-8

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nivolumab therapy for metastatic collecting duct carcinoma after nephrectomy2018

    • Author(s)
      Yasuoka Shotaro、Hamasaki Tsutomu、Kuribayashi Eigo、Nagasawa Masato、Kawaguchi Takanori、Nagashima Yoji、Kondo Yukihiro
    • Journal Title

      Medicine

      Volume: 97 Issue: 45 Pages: e13173-e13173

    • DOI

      10.1097/md.0000000000013173

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Outcomes in Patients With Metastatic Papillary Renal-Cell Carcinoma: A Multi-Institutional Study in Japan2018

    • Author(s)
      Ito Keiichi、、Nagashima Yoji et al.
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 16 Issue: 6 Pages: e1201-e1214

    • DOI

      10.1016/j.clgc.2018.07.028

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hereditary leiomyomatosis and renal cell cancer without cutaneous manifestations in two Japanese siblings2018

    • Author(s)
      Noguchi Go、Furuya Mitsuko、Okubo Yoichiro、Nagashima Yoji、Kato Ikuma、Matsumoto Kana、Tanaka Reiko、Hisasue Shin-ichi、Yao Masahiro、Kishida Takeshi
    • Journal Title

      International Journal of Urology

      Volume: 25 Issue: 9 Pages: 832-835

    • DOI

      10.1111/iju.13760

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histopathological analysis of aggressive renal cell carcinoma harboring a unique germline mutation in fumarate hydratase2018

    • Author(s)
      Matsumoto Kana、Udaka Naoko、Hasumi Hisashi、Nakaigawa Noboru、Nagashima Yoji、Tanaka Reiko、Kato Ikuma、Yao Masahiro、Furuya Mitsuko
    • Journal Title

      Pathology International

      Volume: 68 Issue: 8 Pages: 473-478

    • DOI

      10.1111/pin.12684

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes2018

    • Author(s)
      Hasumi Hisashi、Furuya Mitsuko、Tatsuno Kenji、Aburatani Hiroyuki、Linehan W Marston、Yao Masahiro, et al.
    • Journal Title

      Human Molecular Genetics

      Volume: 印刷中 Issue: 15 Pages: 2712-2724

    • DOI

      10.1093/hmg/ddy181

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 遺伝子疾患と腎腫瘍2018

    • Author(s)
      長嶋洋治、數阪広子
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 7 Pages: 226-233

    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Journal Article] 腎がんの核異型度分類の変遷2018

    • Author(s)
      三上修治、黒田直人、長嶋洋治
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 7 Pages: 313-318

    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Journal Article] Prognostic value of the Glasgow Prognostic Score for patients with metastatic renal cell carcinoma treated by cytoreductive nephrectomy2018

    • Author(s)
      Fukuda Hironori、Takagi Toshio、Kondo Tsunenori、Yoshida Kazuhiko、Shimizu Satoru、Nagashima Yoji、Tanabe Kazunari
    • Journal Title

      Int J Clin Oncol

      Volume: - Issue: 3 Pages: 539-546

    • DOI

      10.1007/s10147-017-1221-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Succinate Dehydrogenase B Subunit?Negative Jugular Foramen Paraganglioma Manifesting Malignant Progression with Pseudohypoxia-Related Atypical Uptake of [ 18 F]-Fluoro-2-Deoxy- d -Glucose: A Case Report2018

    • Author(s)
      Ohtake Makoto、Tateishi Kensuke、Murata Hidetoshi、Nagashima Yoji、Yamanaka Shoji、Yamamoto Tetsuya
    • Journal Title

      World Neurosurgery

      Volume: 114 Pages: 47-52

    • DOI

      10.1016/j.wneu.2018.02.147

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Limited benefit of targeted molecular therapy for inferior vena cava thrombus associated with renal cell carcinoma2017

    • Author(s)
      Fukuda Hironori、Kondo Tsunenori、Takagi Toshio、Iizuka Jumpei、Nagashima Yoji、Tanabe Kazunari
    • Journal Title

      Int J Clin Oncol

      Volume: 22 Issue: 4 Pages: 767-773

    • DOI

      10.1007/s10147-017-1119-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Succinate dehydrogenase B-deficient renal cell carcinoma: A case report with novel germline mutation2017

    • Author(s)
      Iwashita Hiromichi、Okudela Koji、Matsumura Mai、Yamanaka Shoji、Sawazumi Tomoe、Enaka Makiko、Udaka Naoko、Miyake Akio、Hibiya Takashi、Miyake Noriko、Matsumoto Naomichi、Makiyama Kazuhide、Yao Masahiro、Nagashima Yoji、Ohashi Kenichi
    • Journal Title

      Pathol Int

      Volume: 67 Issue: 11 Pages: 585-589

    • DOI

      10.1111/pin.12587

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological study of 5 cases of renal cell carcinoma with t(6;11)(p21;q12).2017

    • Author(s)
      Kuroda N, Yorita K, Sasaki N, Ishihara A, Matsuura K, Daa T, Mori S, Sasaki A, Mikami S, Shigematsu K, Nagashima Y.
    • Journal Title

      Pol J Pathol.

      Volume: 68(1) Pages: 66-72

    • DOI

      10.5114/pjp.2017.67617

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bilateral and multiple mixed epithelial and stromal tumors of the kidney: A case report2017

    • Author(s)
      Minoda Ryo、Takagi Toshio、Toda Naohiro、Itagaki Hiroko、Kondo Tsunenori、Ishida Hideki、Nagashima Yoji、Tanabe Kazunari
    • Journal Title

      Mol Clin Oncol

      Volume: 7 Pages: 1005-1007

    • DOI

      10.3892/mco.2017.1444

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lymphoepithelioma-like carcinoma of the upper urinary tract2017

    • Author(s)
      Lopez-Beltran Antonio、Paner Gladell、Blanca Ana、Montironi Rodolfo、Tsuzuki Toyonori、Nagashima Yoji、Chuang Shi-Sung、Win Khin Than、Madruga Leo、Raspollini Maria R.、Cheng Liang
    • Journal Title

      Hum Pathol

      Volume: 470 Issue: 6 Pages: 703-709

    • DOI

      10.1007/s00428-017-2117-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of metastatic Xp11.2 translocation renal cell carcinoma successfully managed by cytoreductive nephrectomy followed by axitinib therapy2017

    • Author(s)
      Nishimura Koichi、Takagi Toshio、Toda Naohiro、Yamamoto Tomoko、Kondo Tsunenori、Ishida Hideki、Nagashima Yoji、Tanabe Kazunari
    • Journal Title

      Mol Clin Oncol

      Volume: 6 Issue: 3 Pages: 362-364

    • DOI

      10.3892/mco.2017.1142

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports2017

    • Author(s)
      Uchida Shiro、Suzuki Koyu、Uno Mieko、Nozaki Fumi、Li Chih-Ping、Abe Eriko、Yamauchi Teruo、Horiuchi Saya、Kamo Minobu、Hattori Kazunori、Nagashima Yoji
    • Journal Title

      Mol Clin Oncol

      Volume: 7 Issue: 5 Pages: 777-782

    • DOI

      10.3892/mco.2017.1400

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 小児腎移植に偶発的に発見されたpapillary adenoma with foamy cell changeの1例2017

    • Author(s)
      滝澤慶一,服部元史, 秋岡祐子, 近本裕子, 石塚喜世伸, 薮内智朗, 金子直人, 三浦健一郎, 笹田洋平,富井祐治, 小池淳樹, 佐藤泰征, 奥見雅由, 長嶋洋治, 黒田直人
    • Journal Title

      日本臨床腎移植学会雑誌

      Volume: 5 Pages: 43-46

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 病理診断の現状と展望, VII.腎癌の検査・診断腎癌の診断 病理診断, 新腎・泌尿器癌(上)2017

    • Author(s)
      長嶋洋治、廣井敦子、板垣裕子、山本智子, 澤田達男
    • Journal Title

      日本臨牀

      Volume: 75 Pages: 198-202

    • Related Report
      2017 Research-status Report
  • [Journal Article] 腎腫瘍WHO2018新分類2017

    • Author(s)
      三上修治、黒田直人、長嶋洋治
    • Journal Title

      病理と臨床

      Volume: 35 Pages: 894-902

    • Related Report
      2017 Research-status Report
  • [Journal Article] 乳頭状腎腫瘍とその類縁腫瘍2017

    • Author(s)
      菅原江美子、黒田直人、長嶋洋治
    • Journal Title

      病理と臨床

      Volume: 35 Pages: 915-920

    • Related Report
      2017 Research-status Report
  • [Journal Article] 腎細胞癌病理分類の変遷とWHO2016分類の改訂点2017

    • Author(s)
      長嶋洋治、山本彩、中島怜子、森田賢、福田洋典、高木敏男、近藤恒徳
    • Journal Title

      画像診断

      Volume: 37 Pages: 1427-1438

    • Related Report
      2017 Research-status Report
  • [Journal Article] Review of hereditary leiomyomatosis renal cell carcinoma with focus on clinical and pathobiological aspects of renal tumor2017

    • Author(s)
      Kuroda N, Ohe C, Kato I, Furuya M, Baba M, Nagashima Y, Nakatani Y, Murakami I, Zhou M, Michal M, He O, Amin MB
    • Journal Title

      Pol J Pathol

      Volume: 68 Issue: 4 Pages: 284-290

    • DOI

      10.5114/pjp.2017.73920

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 嫌色素性腎細胞癌に特徴的な染色体異常と組織亜型との関係2020

    • Author(s)
      大橋瑠子、大江知里、黒田直人、都築豊徳、長嶋洋治、味岡洋一
    • Organizer
      第9回日本泌尿器病理研究会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] FH欠損腫瘍10例の遺伝学的、疫学的、臨床病理学的検討:HLRCCとの関連を含めて2019

    • Author(s)
      古屋充子、大江知里、黒田直人、田中玲子、長嶋 洋治
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 術後,後腹膜再発・腹膜播種をきたした乳頭状腎細胞癌の1例2019

    • Author(s)
      橋本哲也,野並裕司,金室俊子,鬼塚裕美,板垣裕子,増井憲太,山本智子,澤田達男,長嶋洋治
    • Organizer
      第60回日本臨床細胞学会総会(春季大会)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低酸素反応をはじめとする代謝異常から見る腎腫瘍の新分類2019

    • Author(s)
      長嶋洋治
    • Organizer
      第20回ホルモンと癌研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 分子病理腕内逆位(paracentric inversion) によって融合するRBM10-TFE3腎細胞癌10例の病態解析2019

    • Author(s)
      古屋充子、馬場理也、加藤生真、安田政実、西本紘嗣郎、小山正文、山崎俊成、小川修、中井川昇、蓮見壽史、坂本和優、三神一哉、高木敏男、近藤恒徳、矢尾正祐、長嶋洋治
    • Organizer
      第50回腎癌研究会記念大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Xp11.2転座型腎細胞癌(Xp11.2-RCC)の臨床病理学的特徴2019

    • Author(s)
      福田洋典、加藤生真、古屋充子、近藤恒徳、高木敏男、吉田一彦、室宮泰人、田邉一成、長嶋洋治
    • Organizer
      第50回腎癌研究会記念大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] TFE3再構成腎細胞癌32例の臨床病理学的解析2019

    • Author(s)
      古屋充子, 馬場理也, 加藤生真, 近藤恒徳, 長嶋洋治
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 終末期腎に発生する腎がんは病理組織型固有の分子異常を有する2019

    • Author(s)
      石原 弘喜、山下 聡、服部 奈緒子、吉田 一彦、角田 洋一、高木 敏男、飯塚 淳平、奥見 雅由、種田 積子、近藤 恒徳、長嶋 洋治、田邉 一成、牛島 俊和
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 管状嚢胞性構築を形成する腎細胞癌の臨床病理学的検討2019

    • Author(s)
      長嶋 洋治、山本 智子、石原 弘喜、近藤 恒徳
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 4つのパターンから鑑別する腎腫瘍の病理2019

    • Author(s)
      長嶋洋治
    • Organizer
      日本泌尿器腫瘍学会第5回学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (PGNMID)における糸球体血管内皮障害の検討2019

    • Author(s)
      川西邦夫、澤田杏理、堀田茂、種田積子、奥見雅由、渕之上昌平、服部元史、石田英樹、田邉一成、新田孝作、本田一穂、小池淳樹、長嶋洋治
    • Organizer
      第65回日本病理学会秋期特別総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 下垂体細胞腫の一例2019

    • Author(s)
      清水絢子,村上佳織,橋本哲也,白石彩,高橋伸二,野並裕司、金室俊子,鬼塚裕美,板垣裕子,増井憲太,山本智子,澤田達男,長嶋洋治
    • Organizer
      第58回日本臨床細胞学会秋期総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 記述式子宮内膜細胞診報告様式による判定の実状と有用性2018

    • Author(s)
      岡田薫子,平井康夫,二村梓,秋澤叔香,木原真紀,石谷健,長嶋洋治,則松良明,矢納研二,松井英雄
    • Organizer
      第59回日本臨床細胞学会総会(春期大会)
    • Related Report
      2018 Research-status Report
  • [Presentation] 腎癌の新分類 WHO20162018

    • Author(s)
      長嶋洋治
    • Organizer
      第107回日本病理学会春期総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 若年成人に発症した予後不良乳頭状腎癌に関する分子病理学的検討: FH遺伝子新規変異の一例2018

    • Author(s)
      松元加奈、宇高直子、加藤生真、蓮見壽史、中井川昇、矢尾正祐、田中玲子、長嶋洋治、古屋充子
    • Organizer
      第107回日本病理学会春期総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 本邦のBirt-Hogg-Dube症候群患者における腎癌の病態解析2018

    • Author(s)
      古屋充子、蓮見壽史、長嶋洋治、黒田直人、加藤生真、馬場理也、入部康弘、矢尾正祐
    • Organizer
      第49回腎癌研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 腎腫瘍の病理診断コンサルテーション2001-20172018

    • Author(s)
      長嶋洋治
    • Organizer
      第49回腎癌研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 腎腫瘍の病理2018 腎細胞癌4大組織型といつかは出遭う稀少組織型  -免疫染色だけでどこまでいけるか-2018

    • Author(s)
      長嶋洋治
    • Organizer
      第79回日本病理学会関東支部会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 腎腫瘍の病理診断:WHO2016分類に基づいたレビュー2018

    • Author(s)
      長嶋洋治、加藤生真、古屋充子
    • Organizer
      第77回日本癌学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Xp11.2転座型腎細胞癌における発癌機構研究2018

    • Author(s)
      馬場理也、古屋充子、長嶋洋治、Linehan WM、神波大己 他
    • Organizer
      第77回日本癌学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 悪性転化後、形態変化を生じたpleomorphic xanthoastrocytomaの1例2018

    • Author(s)
      白石彩,金室俊子,野並裕司,鬼塚裕美,板垣裕子,廣井敦子,山本智子,澤田達男,清水辰一郎,長嶋洋治
    • Organizer
      第57回日本臨床細胞学会秋期総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 甲状腺濾胞様腎細胞癌の2例2018

    • Author(s)
      長嶋洋治,鈴木高祐,加藤生真,古屋充子,黒田直人,高木敏男,近藤恒徳,近藤哲夫
    • Organizer
      第64回日本病理学会秋期特別総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Pathologic characteristics of the hereditary renal cell carcinomas Associated with Birt-Hogg-Dube Syndrome.2018

    • Author(s)
      Furuya M, Kato I, Nagashima Y, Kuroda N, Hasumi H, Baba M, Yao M, Nakatani Y
    • Organizer
      107th Annual Meeting of United States and Canadian Association of Patholoy
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 腎腫瘍2016分類―免疫染色だけでどこまでやれるか2018

    • Author(s)
      長嶋洋治
    • Organizer
      第6回獨協医科大学埼玉医療センターセミナー
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 腎腫瘍の組織型分類WHO2016 可能な限りの細胞診添え2018

    • Author(s)
      長嶋洋治
    • Organizer
      第34回熊本県臨床細胞学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] WHO2016に準拠した腎癌の病理診断2018

    • Author(s)
      長嶋洋治
    • Organizer
      第2回Fukuoka Urology Symposium
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 遺伝性平滑筋腫腎細胞癌症候群(HLRCC)の1例2018

    • Author(s)
      野口剛 、古屋充子、大久保陽一郎、長嶋洋治、加藤生真、田中玲子、前嶋愛子、久末伸一、矢尾正祐、岸田健
    • Organizer
      第7回日本泌尿器病理研究会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Clinical features of patients with metastatic renal cancer in whom tumors were first diagnosed as papillary renal cell carcinoma and finally as other renal cancers after a central review: A multi-institutional study in the Japanese Society of Renal Cancer2017

    • Author(s)
      Ito K, Mikami S, Tatsugami K, Masumori N, Shinohara N, Kondo T, Nakanishi S, Nagashima Y, Eto M, Kamba T, Kuroda N, Tomita Y, Matsuyama H, Onishi T, Tsushima T, Nakazawa H, Oya M, Ozono S, Naito S, Asano T, Members of Japanese Society of Renal Cancer
    • Organizer
      American Urological Association 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] TFE3活性化腎細胞癌の診断補助マーカーの探索と評価2017

    • Author(s)
      元島 崇信, 馬場 理也, 蓮見 壽史, 加藤 生真, 長嶋 洋治, 黒田 直人, 高橋 渡, 河野 吉昭, 矢尾 正祐, 江藤 正俊, 神波 大, 古屋 充子
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 皮膚平滑筋腫を有しないFumarate hydratase-deficient RCC (HLRCC-associated RCC)の一例2017

    • Author(s)
      荒木 あずみ,蓮見 壽史, 滝澤 弘樹, 新堀 萌香, 横溝 由美子, 逢坂 公人, 林 成彦, 槙山 和秀, 近藤 慶一, 中井川 昇, 宇高 直子, 長嶋 洋治, 矢尾 正祐
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] ここが変わった 腎癌の病理WHO20162017

    • Author(s)
      長嶋洋治
    • Organizer
      第105回日本泌尿器科学会総会 教育講演「これだけは知っておきたい泌尿器がん病理のエッセンス」
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 明日から役立つ腎細胞癌の病理:免疫組織化学染色を中心に2017

    • Author(s)
      長嶋洋治
    • Organizer
      第105回日本泌尿器科学会総会 知企画シリーズ02
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Xp11.2転座腎細胞癌における発癌分子機構の解明2017

    • Author(s)
      馬場 理也,元島 崇信, 蓮見 壽史, 黄 瑩, Schmidt Laura S, 矢尾 正祐, 長嶋 洋治, 古屋 充子, 尾池 雄一, 江藤 正俊, 神波 大己, Linehan W. Marston
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 若年男性に発症した稀な組織像を呈する腎腫瘍の一例2017

    • Author(s)
      木内静香、朴 鐘建、野口寛子、鈴木宏明、松野吉宏、三上修治、黒田直人、長嶋洋治、山城勝重
    • Organizer
      第106回日本病理学会春期総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 小児腹膜透析患者の固有腎にみられたmetanephric adenoma like cell proliferation の1 小児例2017

    • Author(s)
      種田 積子、富井 裕治、服部 元史、小田 秀明、長嶋 洋治
    • Organizer
      第106回日本病理学会春期総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Birt-Hogg-Dube 症候群を背景に発症する腎腫瘍の分子病理学的特徴2017

    • Author(s)
      古屋 充子、加藤 生真、田中 玲子、長嶋 洋治、黒田 直人、蓮見 寿史、矢尾 正祐、中谷 行雄
    • Organizer
      第106回日本病理学会春期総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腎管状嚢胞癌の1例2017

    • Author(s)
      安原 裕美子、長嶋 洋治
    • Organizer
      第106回日本病理学会春期総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Xp11転座型腎細胞癌11例の臨床病理学的検討2017

    • Author(s)
      長嶋 洋治、加藤 生真、古屋 充子、福田 洋典、高木 敏男、近藤 恒徳
    • Organizer
      第106回日本病理学会春期総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Thyroid-like follicular renal cell carcinoma(TLF-RCC)の一例2017

    • Author(s)
      木村 美和、山本 智子、高木 敏男、近藤 恒徳、近藤 哲夫、長嶋 洋治
    • Organizer
      第106回日本病理学会春期総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 透析患者においてXp11.2転座型腎細胞癌を有した一例2017

    • Author(s)
      笠間江莉, 亀井大悟, 新田孝作、土谷健、高木敏男, 近藤恒徳, 石田英樹, 田邉一成、山本智子, 長嶋洋治、永野正史
    • Organizer
      第62回日本透析医学会学術集会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Xp11.2 転座型腎細胞癌で見られるキメラTFE3 転写因子の機能解析2017

    • Author(s)
      元島崇信、蓮見壽史、黄瑩、佐藤賢文、宮里パオラ、矢尾正祐、長嶋洋治、古屋充子、尾池雄一、神波大己、Schmidt Laura、Lineha W Marston、馬場理也
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 液状化検体細胞診(LBC)の新検体適正基準における診断精度とATEC細胞像の特徴, 教育シンポジウム「記述式内膜細胞診報告様式に於けるATEC」2017

    • Author(s)
      花田 梓,平井康夫,岡田薫子,秋澤叔香,木原真紀,石谷 健,長嶋洋治,則松良明,矢納研二,松井英雄
    • Organizer
      第58回日本臨床細胞学会総会[春期大会]
    • Related Report
      2017 Research-status Report
  • [Presentation] Xp転座型腎細胞癌9 例の臨床病理学的検討2017

    • Author(s)
      長嶋洋治、加藤生真、近藤恒徳、山本智子、古屋充子
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Birt-Hogg-Dube症候群における腎癌の分子病理学的特徴2017

    • Author(s)
      古屋 充子 、蓮見 壽史、加藤 生真、馬場 理也、長嶋 洋治、入部 康弘、中谷 行雄、矢尾 正祐
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] VHL遺伝子に対するFISHはBirt-Hogg-Dube 症候群の淡明細胞型腎細胞癌診断において有用と期待される2017

    • Author(s)
      松元 加奈、加藤 生真、入部 康弘、長嶋 洋治、中谷 行雄、蓮見 寿史、矢尾 正祐、古屋 充子
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腎細胞癌の病理:WHO20162017

    • Author(s)
      長嶋 洋治、福田 洋典、高木 敏男、近藤 恒徳、矢尾 正祐、田邊 一成
    • Organizer
      第55回 日本癌治療学会学術集会(横浜)、臓器別シンポジウム12 : 「それぞれの癌」:診断・治療の現状と展望 -腎癌-
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 腎粘液管状紡錘細胞癌の一例2017

    • Author(s)
      福田学、山田正人、湯澤和彦、吉野美由紀、山本恵美、水口國雄、阿曽達也、高橋美紀子、長嶋洋治、川本雅司
    • Organizer
      第56回 日本臨床細胞学会秋期大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肺腸型腺癌の一例2017

    • Author(s)
      金室俊子、清水彩男、村上佳織、橋本哲也、白石彩、高橋伸治、長谷川嗣業、野並裕司、村松文章、富所貴美子、板垣裕子、廣井敦子、山本智子、澤田達男、長嶋洋治
    • Organizer
      第56回 日本臨床細胞学会秋期大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腎腫瘍の病理WHO2016:免疫染色でだけでどこまでできるか2017

    • Author(s)
      長嶋洋治
    • Organizer
      平成29年度 静岡がんセンター専門病理医養成研修会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 外科病理学(第5版)2020

    • Author(s)
      編集主幹:深山正久、森永正二郎 編集:小田義直、坂元亨宇、松野吉宏、森谷卓也
    • Total Pages
      1892
    • Publisher
      文光堂
    • ISBN
      9784830604812
    • Related Report
      2019 Annual Research Report
  • [Book] 知っておきたい泌尿器のCT・MRI 改訂第2版2019

    • Author(s)
      山下康行
    • Total Pages
      624
    • Publisher
      学研メディカル秀潤社
    • ISBN
      4780909732
    • Related Report
      2018 Research-status Report
  • [Book] Year Book of RCC 20172018

    • Author(s)
      長嶋洋治、菅原江美子、稲村健太郎、小島史好、三上修治、黒田直人(分担)
    • Total Pages
      149
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779219962
    • Related Report
      2017 Research-status Report
  • [Book] 腎癌診療ガイドライン 2017年版2017

    • Author(s)
      長嶋洋治(分担)
    • Total Pages
      126
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779218644
    • Related Report
      2017 Research-status Report
  • [Remarks] 東京女子医科大学 病理診断科

    • URL

      http://www.twmu.ac.jp/univ/medical/subject/detail.php?id=02030

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京女子医科大学 教員情報 長嶋洋治

    • URL

      https://gyoseki.twmu.ac.jp/twmhp/KgApp?kyoinId=ymiygsyoggs

    • Related Report
      2018 Research-status Report
  • [Remarks] 東京女子医科大学病理診断科

    • URL

      http://www.twmu.ac.jp/univ/medical/subject/detail.php?id=02030

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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