Clinicopathological and molecular biological studies of RCCs based on WHO2016 classification
Project/Area Number |
17K11162
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
Nagashima Yoji 東京女子医科大学, 医学部, 教授 (10217995)
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Co-Investigator(Kenkyū-buntansha) |
近藤 恒徳 東京女子医科大学, 医学部, 教授 (50301544)
加藤 生真 横浜市立大学, 医学部, 助教 (80644939)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 腎癌(腎細胞癌) / MiT転座型腎癌 / 透析関連腎癌 / フマル酸ヒドラターゼ欠損腎癌 / コハク酸脱水素酵素欠損腎癌 / 腎髄質癌 / 腎細胞癌 / 臨床病理学的研究 / MiT転座型腎細胞癌 / 透析関連腎細胞癌 / FH欠損性7腎細胞癌 / 嫌色素性腎細胞癌 / 予後因子 / 腎癌(腎細胞癌) / WHO2016分類 / MIT転座型腎細胞癌 / 後天性嚢胞腎随伴腎細胞癌 / HLRCC随伴腎細胞癌 / 腎腫瘍 / WHO分類 / MiT転座型 / HOCT / SDH欠損型腎細胞癌 / FH欠損型腎細胞癌 / Renal cell carcinoma / WHO2016 classification / Novel histological types |
Outline of Final Research Achievements |
We selected uncommon histological types (Mit-translocation type, dialysis-related or enzyme deficiency-associated) of renal cell carcinoma (RCC) in archval cases in our institute and consultation files, and analyzed clinicopathologically. We obtained the achievements, as follows; 1)MiT family translocation-associated RCC includes TFE3 translocation type. We identified that RBM10-TFE3 translocated cases are often associated with chroni kidney diseases. 2) We found the EWSR1 gene as a novel translocation partner of TFE3 gene. 3) We analyzed 10 patients with hereditary leiomyomatosis-RCC syndrome. Their RCC frequently showed positivity for PD-L1, which might present feasibility of immuno-oncological drugs as a therapeutic option. 4) Additionally, we report a very rare cases , i.e. mucinous tubular and spindle cell carcinoma, succnate dehydrogenase-deficient RCC, and medullary renal cell carcinoma with sickle cell trait. The medullary renal cell carcinoma is first report in Japan.
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Academic Significance and Societal Importance of the Research Achievements |
腎癌の頻度は必ずしも高くないが、多数の新規組織型がある。MiT転座型腎癌、酵素欠損性腎癌、透析関連腎癌などである。WHOでは2016年に最新の分類を出版した。本研究では腎癌新規組織型を多数例を検討し、本邦での臨床病理学的性質や組織型特異的なバイオマーカー、治療標的を明らかにした。
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Report
(4 results)
Research Products
(96 results)
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[Journal Article] TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease2019
Author(s)
Baba M, Furuya M, Motoshima T, Lang M, Funasaki S, Ma W, Sun H-W, Dr. Hasumi H, Huang Y , Kato I , Kadomatsu T, Satou Y, Morris N , Karim BO, Ileva L , Kalen JD , Krisna LAW , Hasumi Y , Sugiyama A, Kurahashi R, Nishimoto K , Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M , Kamba T, Suda T , Oike Y, Schmidt LSS:
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Journal Title
Mol Cancer Res
Volume: -
Pages: -
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 小児腎移植に偶発的に発見されたpapillary adenoma with foamy cell changeの1例2017
Author(s)
滝澤慶一,服部元史, 秋岡祐子, 近本裕子, 石塚喜世伸, 薮内智朗, 金子直人, 三浦健一郎, 笹田洋平,富井祐治, 小池淳樹, 佐藤泰征, 奥見雅由, 長嶋洋治, 黒田直人
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Journal Title
日本臨床腎移植学会雑誌
Volume: 5
Pages: 43~46
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Peer Reviewed
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[Presentation] Clinical features of patients with metastatic renal cancer in whom tumors were first diagnosed as papillary renal cell carcinoma and finally as other renal cancers after a central review: A multi-institutional study in the Japanese Society of Renal Cancer2017
Author(s)
Ito K, Mikami S, Tatsugami K, Masumori N, Shinohara N, Kondo T, Nakanishi S, Nagashima Y, Eto M, Kamba T, Kuroda N, Tomita Y, Matsuyama H, Onishi T, Tsushima T, Nakazawa H, Oya M, Ozono S, Naito S, Asano T, Members of Japanese Society of Renal Cancer
Organizer
American Urological Association 2017
Related Report
Int'l Joint Research
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[Presentation] TFE3活性化腎細胞癌の診断補助マーカーの探索と評価2017
Author(s)
元島 崇信, 馬場 理也, 蓮見 壽史, 加藤 生真, 長嶋 洋治, 黒田 直人, 高橋 渡, 河野 吉昭, 矢尾 正祐, 江藤 正俊, 神波 大, 古屋 充子
Organizer
第105回日本泌尿器科学会総会
Related Report
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[Presentation] 皮膚平滑筋腫を有しないFumarate hydratase-deficient RCC (HLRCC-associated RCC)の一例2017
Author(s)
荒木 あずみ,蓮見 壽史, 滝澤 弘樹, 新堀 萌香, 横溝 由美子, 逢坂 公人, 林 成彦, 槙山 和秀, 近藤 慶一, 中井川 昇, 宇高 直子, 長嶋 洋治, 矢尾 正祐
Organizer
第105回日本泌尿器科学会総会
Related Report
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[Presentation] Xp11.2転座腎細胞癌における発癌分子機構の解明2017
Author(s)
馬場 理也,元島 崇信, 蓮見 壽史, 黄 瑩, Schmidt Laura S, 矢尾 正祐, 長嶋 洋治, 古屋 充子, 尾池 雄一, 江藤 正俊, 神波 大己, Linehan W. Marston
Organizer
第105回日本泌尿器科学会総会
Related Report
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