• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The utility of microbubble perfusion contrast-enhanced ultrasound imaging for detection of sentinel node metastasis in endometrial cancer

Research Project

Project/Area Number 17K11264
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

NIIKURA Hitoshi  東北大学, 医学系研究科, 非常勤講師 (80261634)

Co-Investigator(Kenkyū-buntansha) 森 菜緒子  東北大学, 大学病院, 助教 (90535064)
岡本 聡  東北大学, 大学病院, 臨床検査技師 (40420020)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords子宮体癌 / センチネルリンパ節 / マイクロバブル造影 / 超音波 / パワードップラー / 微小転移
Outline of Final Research Achievements

This research was performed to evaluate whether quantitative analysis of perfusion contrast-enhanced ultrasound (CE-US) could predict early lymph node metastasis in clinically node-negative endometrial cancer. Sentinel lymph nodes could be detected at pelvic cavity in 28 endometrial cancer patients and 11 cervical cancer patients. They were selected for perfusion CE-US imaging. Forty lymph nodes were histologically diagnosed as negative for metastasis and 17 were positive. There was a significant difference in PI ratio and the PI difference between the LN-negative and LN-positive metastasis groups. Parameters from the quantitative analysis of perfusion CE-US imaging showed significant differences between the LN-negative and -positive metastasis groups in endometrial cancer and cervical cancer. Quantitative analysis of perfusion contrast-enhanced ultrasound may be effective for detection of sentinel node metastasis inpatients with gynecological cancer.

Academic Significance and Societal Importance of the Research Achievements

子宮体癌をはじめとする婦人科がんにおいてマイクロバブル造影超音波画像定量解析によるセンチネルリンパ節転移診断が可能になることで、広範囲のリンパ節郭清によるリンパ浮腫の発現をはじめとする患者のQOLの低下は勿論のことこれまで少数のセンチネルリンパ節を生検することにより発生していた副障害に至るまで予防することが可能になる。さらには手術中の迅速病理診断にかかわる病理医をはじめとするスタッフの負担軽減がはかられ、医療にかかわる人的資源の有効活用も可能になる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2019 2017

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Sentinel node navigation surgery in cervical and endometrial cancer: a review2019

    • Author(s)
      Niikura Hitoshi、Tsuji Keita、Tokunaga Hideki、Shimada Muneaki、Ishikawa Mitsuya、Yaegashi Nobuo
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 49 Issue: 6 Pages: 495-500

    • DOI

      10.1093/jjco/hyz062

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sentinel Node Navigation Surgery2019

    • Author(s)
      Niikura Hitoshi
    • Journal Title

      Surgery for Gynecological cancer (Springer)

      Volume: - Pages: 237-245

    • DOI

      10.1007/978-981-13-1519-0_15

    • ISBN
      9789811315183, 9789811315190
    • Related Report
      2019 Annual Research Report
  • [Journal Article] 婦人科がん低侵襲治療の現状と展望―子宮体癌、センチネルリンパ節生検2017

    • Author(s)
      新倉 仁
    • Journal Title

      臨床婦人科産科

      Volume: 第71巻3号 Pages: 328-334

    • Related Report
      2017 Research-status Report
  • [Presentation] 子宮頸がんセンチネルリンパ節生検2019

    • Author(s)
      新倉 仁
    • Organizer
      第71回日本産科婦人科学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 婦人科がんにおけるSNNSのこれまでとこれから2019

    • Author(s)
      新倉 仁、岡本 聡、土岐麻実、永井智之、徳永英樹、島田宗昭、八重樫伸生
    • Organizer
      第20回SNNS研究会学術集会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi