| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
|---|
| Outline of Final Research Achievements |
Caloric stimulation was applied to C57BL / 6 mice, but the reproducibility of nystagmus findings was not high. Therefore, although there is no report on mice, we tried galvanic stimulation, which is a proven vestibular stimulation method in other animal species. The response of the cerebral cortex changed according to the stimulation frequency, and it was found that the vestibular area, which seems to be PIVC, responded to low-frequency stimulation, and the auditory cortex responded to higher-frequency stimulation. Next, a similar experiment was performed on GCaMP6 mice that can be imaged at several times the intensity of flavoprotein fluorescence. Similar to C57BL / 6 mice, the vestibular area, which seems to be PIVC, tended to respond to low-frequency stimulation, and the auditory cortex tended to respond to high-frequency stimulation, and the response intensity of imaging increased.
|
