Establishment of intraoperative macular function evaluation system
Project/Area Number |
17K11430
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Saitama Medical University |
Principal Investigator |
Shinoda Kei 埼玉医科大学, 医学部, 教授 (60245561)
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Co-Investigator(Kenkyū-buntansha) |
松本 惣一 帝京大学, 医学部, 講師 (00305054)
今村 裕 帝京大学, 医学部, 准教授 (20276215)
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Project Period (FY) |
2017-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
Keywords | 硝子体手術 / 網膜電図 / 視覚生理 / 眼科手術 / 緑内障手術 / 眼内温度 / 皮膚電極 / 多局所網膜電図 / 周術期機能評価 / 術中機能評価 / 内眼手術 / 局所網膜電図 / 網膜硝子体手術 / 黄斑疾患 / 生理学 / 臨床 / 眼科 |
Outline of Final Research Achievements |
We worked on the development of focal macular electrocardiogram recording during vitreous surgery, and confirmed that it is possible to record electrocardiogram from the macula and that it is possible to monitor the recording image with high quality. In parallel, we searched for a method to evaluate entire or local retinal function during and early postoperative period using full-field electroretinogram and multilocal electroretinogram, and it was confirmed that these are possible by using a portable LED contact lens electrode and skin electrodes safely and less invasibly.
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Academic Significance and Societal Importance of the Research Achievements |
硝子体手術をはじめとする眼科顕微鏡手術は、観察系および器械・器具の進化、補助薬剤の使用、病態理解の深化などによって適応が広がり成績も向上しているが、手術中に網膜機能そして特に黄斑機能を評価する方法は過去にない。今回の研究は、治療としての手術に同時に機能評価としての検査機能を付与するものである。手術中の網膜断面像観察や蛍光眼底造影検査などの形態、循環評価に加えて、機能をモニターできることにより、手術そのものの開発や、術中手術戦略の向上に寄与でき、さらなる治療生成の向上につながる可能性がある。
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Report
(6 results)
Research Products
(75 results)
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[Journal Article] Ocular findings in Japanese patients with hydroxychloroquine retinopathy developing within 3 years of treatment.2021
Author(s)
Ozawa H, Ueno S, Ohno-Tanaka A, Sakai T, Hashiguchi M, Shimizu M, Fujinami K, Ahn SJ, Kondo M, Browning DJ, Shinoda K, Yokogawa N.
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Journal Title
Jpn J Ophthalmol.
Volume: 65
Issue: 4
Pages: 472-481
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] RP2-associated retinal disorder in a Japanese cohort: Report of novel variants and a literature review, identifying a genotype-phenotype association.2020
Author(s)
Fujinami K, Liu X, Ueno S, Mizota A, Shinoda K, Kuniyoshi K, Fujinami-Yokokawa Y, Yang L, Arno G, Pontikos N, Kameya S, Kominami T, Terasaki H, Sakuramoto H, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Yoshiake K, Iwata T, Tsunoda K; Japan Eye Genetics Consortium Study Group.
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Journal Title
Am J Med Genet C Semin Med Genet.
Volume: 184
Issue: 3
Pages: 675-693
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical and genetic characteristics of 10 Japanese patients with PROM1-associated retinal disorder: A report of the phenotype spectrum and a literature review in the Japanese population.2020
Author(s)
Fujinami K, Oishi A, Yang L, Arno G, Pontikos N, Yoshitake K, Fujinami-Yokokawa Y, Liu X, Hayashi T, Katagiri S, Mizobuchi K, Mizota A, Shinoda K, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Iwata T, Tsujikawa A, Tsunoda K; Japan Eye Genetics Consortium study group.
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Journal Title
Am J Med Genet C Semin Med Genet.
Volume: 184
Issue: 3
Pages: 656-674
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association2020
Author(s)
Fujinami-Yokokawa Y, Fujinami K, Kuniyoshi K, Hayashi T, Ueno S, Mizota A, Shinoda K, Arno G, Pontikos N, Yang L, Liu X, Sakuramoto H, Katagiri S, Mizobuchi K, Kominami T, Terasaki H, Nakamura N, Kameya S, Yoshitake K, Miyake Y, Kurihara T, Tsubota K, Miyata H, Iwata T, Tsunoda K; Japan Eye Genetics Consortium.
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Journal Title
Sci Rep
Volume: 12
Issue: 1
Pages: 9531-9531
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency.2020
Author(s)
Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
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Journal Title
Sci Rep.
Volume: 10
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 網脈絡膜ジストロフィの遺伝学的病態解明および治療に向けた症例データバンクの構築(総説)2020
Author(s)
角田 和繁(国立病院機構東京医療センター臨床研究センター感覚器センター 視覚研究部), 岩田 岳, 藤波 芳, 吉武 和敏, 國吉 一樹, 近藤 峰生, 林 孝彰, 上野 真治, 篠田 啓, 亀谷 修平, 近藤 寛之, 中村 誠, 直井 信久, 三宅 養三
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Journal Title
日本眼科学会雑誌
Volume: 124
Pages: 247-284
Related Report
Peer Reviewed
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[Journal Article] Characterization of GUCA1A-associated dominant cone/cone-rod dystrophy: low prevalence among Japanese patients with inherited retinal dystrophies.2019
Author(s)
Mizobuchi K, Hayashi T, Katagiri S, Yoshitake K, Fujinami K, Yang L, Kuniyoshi K, Shinoda K, Machida S, Kondo M, Ueno S, Terasaki H, Matsuura T, Tsunoda K, Iwata T, Nakano T.
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Journal Title
Sci Rep.
Volume: 9
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 小児てんかんに対するビガバトリン投与症例の皮膚電極を用いた網膜電図による網膜機能のモニターリング2019
Author(s)
尾崎 公威, 菊地 俊介, 宮腰 瞳, 西山 友理, 菅野 順二, 佐々木 貴優, 松本 惣一, 堀田 一樹, 河越 龍方, 篠田 啓, 颯佐 かおり, 山内 秀雄
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Journal Title
眼科臨床紀要
Volume: 12
Pages: 743-748
NAID
Related Report
Peer Reviewed
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[Presentation] Comparison of macular function before and after micropulse subthreshold coagulation for diabetic macular edema using skin electrode multi-focal electroretinogram2020
Author(s)
Shunichiro Takano, Kimitake Ozaki, Yuji Yoshikawa, Tomoyuki Kumagai, Hirokazu Ishii, Takanori Sasaki, Yuro Igawa, Junji Kanno, Hisashi Ibuki, Airi Shimura, Takamitsu Nagashima, Takuhei Shoji, Kei Shinoda
Organizer
58th ISCEV Symposium
Related Report
Int'l Joint Research
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[Presentation] Electrophysiological findings of patients with RPGR-associated retinal disorder.2020
Author(s)
NATSUKO Nakamura, Kaoru Fujinami, NOBUHISA Naoi, YASUHIRO Ikeda, TAKAAKI Hayashi, SHINJI Ueno, HIROKO Terasaki, KAZUKI Kuniyoshi, ATSUSHI Mizota, KEI Shinoda, et al.
Organizer
58th ISCEV Symposium
Related Report
Int'l Joint Research
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