Development of bio-nanosheet for newly ophthalmic treatment devices
Project/Area Number |
17K11478
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | University of Yamanashi |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
武岡 真司 早稲田大学, 理工学術院, 教授 (20222094)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | バイオナノシート / 緑内障 / 角膜障害 / drug delivery system / 生体分解性超薄膜 / 眼科 / 創傷治癒促進 / ドラッグデリバリーシステム / ナノバイオ / 眼科学 |
Outline of Final Research Achievements |
The applications of biodegradable ultra-thin films (bio-nanosheets) in the following ophthalmic fields was studied. 1. The application of bio-nanosheets as an agent to promote the closure of wounds caused by surgery and trauma. We tried to close surgically created wound on the cornea or sclera of a small animal by covering with bio-nanosheet. 2. The application as a drug delivery system (DDS) was examined. 3. We examined the usefulness of the drug as a containing material for ocular tissue damage such as severe corneal epithelial disorders. 4. Exploring the possibility of using the bio-nanosheets as a control material for immigrating transplanted cells. 5We also examined the applicability as an adjuvant for glaucoma filtration surgery. Anti-adhesion properties of bio-nanosheets and the loading of anti-adhesion agents were used to prevent tissue adhesion.
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Academic Significance and Societal Importance of the Research Achievements |
眼球は透明性が維持される必要がある器官で血管の侵入がないため、組織の修復力が弱いなど組織特異性を有する。また眼球は眼表面にあるため、点眼薬などの局所薬を治療に用いることが多いが、薬剤滴下は臨床的に困難な詳細が多い。またアドヒアランスの不良例も少なくない。 今回の研究でバイオナノシートが現在の眼科医療が有するいくつかのアンメットニーズに対する治療の可能性を示すことが出来た。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association2020
Author(s)
Fujinami-Yokokawa Y, Fujinami K, Kuniyoshi K, Hayashi T, Ueno S, Mizota A, Shinoda K, Arno G, Pontikos N, Yang L, Liu X, Sakuramoto H, Katagiri S, Mizobuchi K, Kominami T, Terasaki H, Nakamura N, Kameya S, Yoshitake K, Miyake Y, Kurihara T, Tsubota K, Miyata H, Iwata T, Tsunoda K; Japan Eye Genetics Consortium.
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Journal Title
Sci Rep
Volume: 12
Issue: 1
Pages: 9531-9531
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The usefulness of the Deep Learning method of variational autoencoder to reduce measurement noise in glaucomatous visual fields2020
Author(s)
Asaoka R, Murata H, Asano S, Matsuura M, Fujino Y, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N.
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Journal Title
Sci Rep
Volume: 12
Issue: 1
Pages: 7893-7893
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genetic factors associated with response to as-needed aflibercept therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy2020
Author(s)
Yoneyama S, Sakurada Y, Kikushima W, Sugiyama A, Matsubara M, Fukuda Y, Tanabe N, Parikh R, Mabuchi F, Kashiwagi K, Iijima H.
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Journal Title
Sci Rep
Volume: 28
Issue: 1
Pages: 7188-7188
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency.2020
Author(s)
Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
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Journal Title
Sci Rep.
Volume: 10
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genetic variants associated with the onset and progression of primary open-angle glaucoma2020
Author(s)
Mabuchi F, Mabuchi N, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Takamoto M, Aihara M, Iwata T, Hashimoto K, Sato K, Shiga Y, Nishiguchi KM, Nakazawa T, Akiyama M, Kawase K, Ozaki M, Araie M, Japan Glaucoma Society Omics Group (JGS-OG)
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Journal Title
American Journal of Ophthalmology
Volume: 212
Pages: 135-140
DOI
Related Report
Peer Reviewed
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[Journal Article] Usefulness of data augmentation for visual field trend analyses in patients with glaucoma.2020
Author(s)
Asaoka R, Murata H, Matsuura M, Fujino Y, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N.
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Journal Title
Br J Ophthalmol.
Volume: **
Issue: 12
Pages: 315027-315027
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 原著 新規配合剤導入による緑内障点眼忘れの変化と点眼忘れに影響する因子の全国前向き調査研究2018
Author(s)
長谷部 優花(山梨大学 医学部眼科学教室), 坂本 雅子, 柏木 賢治, 津村 豊明, 鈴木 康之, 吉川 啓司, 鈴村 弘隆, 前田 利根, 齋藤 瞳, 竹田 竜嗣, 新家 眞
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Journal Title
眼科
Volume: 60
Issue: 4
Pages: 411-420
DOI
ISSN
0016-4488
Year and Date
2018-04-05
Related Report
Peer Reviewed
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[Presentation] 次世代眼科医療を目指す、ICT/人工知能を活用した画像等データベースの基盤構築プロジェクト、システム構築報告(第二報)2019
Author(s)
長谷川 高志, 柏木 賢治, 三宅 正裕, 坂本 泰二, 大鹿 哲郎, 福重 秀文, 井上 仁, 宇都木 仁, 本郷 勝義, 南 常治, 畑中 正行
Organizer
第39回医療情報学連合大会
Related Report
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