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Development of bio-nanosheet for newly ophthalmic treatment devices

Research Project

Project/Area Number 17K11478
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Yamanashi

Principal Investigator

Kashiwagi Kenji  山梨大学, 大学院総合研究部, 教授 (30194723)

Co-Investigator(Kenkyū-buntansha) 武岡 真司  早稲田大学, 理工学術院, 教授 (20222094)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsバイオナノシート / 緑内障 / 角膜障害 / drug delivery system / 生体分解性超薄膜 / 眼科 / 創傷治癒促進 / ドラッグデリバリーシステム / ナノバイオ / 眼科学
Outline of Final Research Achievements

The applications of biodegradable ultra-thin films (bio-nanosheets) in the following ophthalmic fields was studied. 1. The application of bio-nanosheets as an agent to promote the closure of wounds caused by surgery and trauma. We tried to close surgically created wound on the cornea or sclera of a small animal by covering with bio-nanosheet. 2. The application as a drug delivery system (DDS) was examined. 3. We examined the usefulness of the drug as a containing material for ocular tissue damage such as severe corneal epithelial disorders. 4. Exploring the possibility of using the bio-nanosheets as a control material for immigrating transplanted cells. 5We also examined the applicability as an adjuvant for glaucoma filtration surgery. Anti-adhesion properties of bio-nanosheets and the loading of anti-adhesion agents were used to prevent tissue adhesion.

Academic Significance and Societal Importance of the Research Achievements

眼球は透明性が維持される必要がある器官で血管の侵入がないため、組織の修復力が弱いなど組織特異性を有する。また眼球は眼表面にあるため、点眼薬などの局所薬を治療に用いることが多いが、薬剤滴下は臨床的に困難な詳細が多い。またアドヒアランスの不良例も少なくない。
今回の研究でバイオナノシートが現在の眼科医療が有するいくつかのアンメットニーズに対する治療の可能性を示すことが出来た。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (43 results)

All 2020 2019 2018 2017

All Journal Article (28 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 24 results,  Open Access: 19 results) Presentation (15 results) (of which Invited: 1 results)

  • [Journal Article] Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association2020

    • Author(s)
      Fujinami-Yokokawa Y, Fujinami K, Kuniyoshi K, Hayashi T, Ueno S, Mizota A, Shinoda K, Arno G, Pontikos N, Yang L, Liu X, Sakuramoto H, Katagiri S, Mizobuchi K, Kominami T, Terasaki H, Nakamura N, Kameya S, Yoshitake K, Miyake Y, Kurihara T, Tsubota K, Miyata H, Iwata T, Tsunoda K; Japan Eye Genetics Consortium.
    • Journal Title

      Sci Rep

      Volume: 12 Issue: 1 Pages: 9531-9531

    • DOI

      10.1038/s41598-020-65737-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persistence and treatment patterns of fixed combination drugs for glaucoma: a retrospective claims database study in Japan2020

    • Author(s)
      Kashiwagi K, Chono E, Koesters S, Yap PS.
    • Journal Title

      BMC Ophthalmol

      Volume: 10 Issue: 1 Pages: 223-223

    • DOI

      10.1186/s12886-020-01508-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of CRP levels with ARMS2 and CFH variants in age-related macular degeneration2020

    • Author(s)
      Shijo T, Sakurada Y, Fukuda Y, Yoneyama S, Sugiyama A, Matsubara M, Kikushima W, Tanabe N, Parikh R, Kashiwagi K.
    • Journal Title

      Int Ophthalmol

      Volume: 7 Issue: 10 Pages: 2735-2742

    • DOI

      10.1007/s10792-020-01460-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The usefulness of the Deep Learning method of variational autoencoder to reduce measurement noise in glaucomatous visual fields2020

    • Author(s)
      Asaoka R, Murata H, Asano S, Matsuura M, Fujino Y, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N.
    • Journal Title

      Sci Rep

      Volume: 12 Issue: 1 Pages: 7893-7893

    • DOI

      10.1038/s41598-020-64869-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic factors associated with response to as-needed aflibercept therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy2020

    • Author(s)
      Yoneyama S, Sakurada Y, Kikushima W, Sugiyama A, Matsubara M, Fukuda Y, Tanabe N, Parikh R, Mabuchi F, Kashiwagi K, Iijima H.
    • Journal Title

      Sci Rep

      Volume: 28 Issue: 1 Pages: 7188-7188

    • DOI

      10.1038/s41598-020-64301-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency.2020

    • Author(s)
      Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-020-62119-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic variants associated with the onset and progression of primary open-angle glaucoma2020

    • Author(s)
      Mabuchi F, Mabuchi N, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata Z, Takamoto M, Aihara M, Iwata T, Hashimoto K, Sato K, Shiga Y, Nishiguchi KM, Nakazawa T, Akiyama M, Kawase K, Ozaki M, Araie M, Japan Glaucoma Society Omics Group (JGS-OG)
    • Journal Title

      American Journal of Ophthalmology

      Volume: 212 Pages: 135-140

    • DOI

      10.1016/j.ajo.2020.03.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of data augmentation for visual field trend analyses in patients with glaucoma.2020

    • Author(s)
      Asaoka R, Murata H, Matsuura M, Fujino Y, Miki A, Tanito M, Mizoue S, Mori K, Suzuki K, Yamashita T, Kashiwagi K, Shoji N.
    • Journal Title

      Br J Ophthalmol.

      Volume: ** Issue: 12 Pages: 315027-315027

    • DOI

      10.1136/bjophthalmol-2019-315027

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent epidemiological status of ocular and other major complications related to diabetes mellitus in Japan2020

    • Author(s)
      Kume A, Kashiwagi K.
    • Journal Title

      Ophthalmologica

      Volume: 25 Issue: 6 Pages: 404-412

    • DOI

      10.1159/000506747

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validating the efficacy of the binomial pointwise linear regression method to detect glaucoma progression with multicentral database2019

    • Author(s)
      Asano Shotaro、Murata Hiroshi、Matsuura Masato、Fujino Yuri、Miki Atsuya、Tanito Masaki、Mizoue Shiro、Mori Kazuhiko、Suzuki Katsuyoshi、Yamashita Takehiro、Kashiwagi Kenji、Shoji Nobuyuki、Zangwill Linda M、Asaoka Ryo
    • Journal Title

      British Journal of Ophthalmology

      Volume: 104 Issue: 4 Pages: 569-574

    • DOI

      10.1136/bjophthalmol-2019-314136

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wide Variation of Squeezing Force and Dispensing Time Interval among Eyedropper Bottles2019

    • Author(s)
      Kashiwagi K.
    • Journal Title

      J Ophthalmol

      Volume: 16 Pages: 7250563-7250563

    • DOI

      10.1155/2019/7250563

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of deep convolutional neural networks for glaucoma detection.2019

    • Author(s)
      Phan S, Satoh S, Yoda Y, Kashiwagi K, Oshika T, Japan Ocular Imaging Registry Research Group.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: Feb 24 Issue: 3 Pages: 276-283

    • DOI

      10.1007/s10384-019-00659-6

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 薬剤師なら知っておきたい 薬剤性眼障害のキホン(第1回) 薬剤性眼障害とは2019

    • Author(s)
      柏木 賢治(山梨大学 医学部眼科学教室)
    • Journal Title

      調剤と情報(1341-5212)25巻3号 Page414-418(2019.02)

      Volume: 25 Pages: 414-418

    • NAID

      40021797102

    • Related Report
      2018 Research-status Report
  • [Journal Article] 原著 新規配合剤導入による緑内障点眼忘れの変化と点眼忘れに影響する因子の全国前向き調査研究2018

    • Author(s)
      長谷部 優花(山梨大学 医学部眼科学教室), 坂本 雅子, 柏木 賢治, 津村 豊明, 鈴木 康之, 吉川 啓司, 鈴村 弘隆, 前田 利根, 齋藤 瞳, 竹田 竜嗣, 新家 眞
    • Journal Title

      眼科

      Volume: 60 Issue: 4 Pages: 411-420

    • DOI

      10.18888/ga.0000000634

    • ISSN
      0016-4488
    • Year and Date
      2018-04-05
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A nationwide survey of factors influencing adherence to ocular hypotensive eyedrops in Japan2018

    • Author(s)
      Tsumura T, Kashiwagi K, Suzuki Y, Yoshikawa K, Suzumura H, Maeda T, Takeda R, Saito H, Araie M
    • Journal Title

      Int Ophthalmol

      Volume: - Issue: 2 Pages: 1-9

    • DOI

      10.1007/s10792-018-0820-7

    • Related Report
      2019 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【IT・AI未来眼科学】 緑内障のビッグデータ2018

    • Author(s)
      柏木 賢治(山梨大学 眼科)
    • Journal Title

      OCULISTA(2187-5855)69号 Page26-31(2018.12)

      Volume: 69 Pages: 26-31

    • Related Report
      2018 Research-status Report
  • [Journal Article] 【わかりやすい感覚器疾患】 感覚器疾患のみかた 視覚 健康診断で注意すべき眼疾患2018

    • Author(s)
      柏木 賢治(山梨大学 医学部眼科学教室)
    • Journal Title

      日本医師会雑誌(0021-4493)147巻特別1 Page S138-S139(2018.06)

      Volume: 147

    • Related Report
      2018 Research-status Report
  • [Journal Article] Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma2018

    • Author(s)
      Shiga Yukihiro、Kashiwagi Kenji、Nakazawa Toru、Kubo Michiaki、Japan Glaucoma Society Omics Group (JGS-OG)、NEIGHBORHOOD Consortium
    • Journal Title

      Human Molecular Genetics

      Volume: 27 Issue: 8 Pages: 1486-1496

    • DOI

      10.1093/hmg/ddy053

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Longitudinal Change in Peripheral Anterior Chamber Depth of Eyes with Angle Closure after Laser Iridotomy.2018

    • Author(s)
      Furuya T, Kashiwagi K.
    • Journal Title

      J Ophthalmol.

      Volume: - Pages: 1-7

    • DOI

      10.1155/2018/9106247

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microglia mediate non-cell-autonomous cell death of retinal ganglion cells.2018

    • Author(s)
      Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S.
    • Journal Title

      Glia

      Volume: 66 Issue: 11 Pages: 2366-2384

    • DOI

      10.1002/glia.23475

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in adherence and associated factors among patients on newly introduced prostaglandin analog and timolol fixed-combination therapy.2018

    • Author(s)
      Hasebe Y, Kashiwagi K, Tsumura T, Suzuki Y, Yoshikawa K, Suzumura H, Maeda T, Takeda R, Saito H, Araie M.
    • Journal Title

      Patient Prefer Adherence.

      Volume: 12 Pages: 1567-1577

    • DOI

      10.1155/2018/8165476

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validating Variational Bayes Linear Regression Method With Multi-Central Datasets2018

    • Author(s)
      村田博史、Linda M. Zangwill、藤野友里、松浦将人、三木篤也 、平澤一法、谷戸正樹、溝上史郎、森和彦、鈴木克佳、山下高明、柏木賢治、庄司信行、朝岡亮
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 59 Issue: 5 Pages: 1897-1897

    • DOI

      10.1167/iovs.17-22907

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and Safety of Switching Prostaglandin Analog Monotherapy to Tafluprost/Timolol Fixed-Combination Therapy2018

    • Author(s)
      Kitamura Kazuyoshi、Chiba Tatsuya、Mabuchi Fumihiko、Ishijima Kiyotaka、Omoto Shu、Kashiwagi Fumiko、Godo Takashi、Kogure Satoshi、Goto Teruhiko、Shibuya Takashi、Tanabe Jhoji、Tsukahara Shigeo、Tsuchiya Tadaharu、Tsumura Toyoaki、Tokunaga Takaharu、Hosaka Osamu、Saito Tetsunori、Kashiwagi Kenji
    • Journal Title

      Journal of Ophthalmology

      Volume: 2018 Pages: 1-9

    • DOI

      10.1155/2018/8456764

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 眼科手術の適応-最新情報 4.緑内障 2)トラベクトーム手術2017

    • Author(s)
      柏木 賢治
    • Journal Title

      眼科

      Volume: 59 Issue: 10 Pages: 1079-1084

    • DOI

      10.18888/ga.0000000145

    • ISSN
      0016-4488
    • Year and Date
      2017-09-30
    • Related Report
      2017 Research-status Report
  • [Journal Article] Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS72017

    • Author(s)
      Shiga Yukihiro、Kashiwagi Kenji、Nakazawa Toru、for the Japan Glaucoma Society Omics Group (JGS-OG)
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 12 Pages: e0186678-e0186678

    • DOI

      10.1371/journal.pone.0186678

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in Glaucoma Medication during the Past Eight Years and Future Directions in Japan Based on an Insurance Medical Claim Database2017

    • Author(s)
      Sakamoto Masako、Kitamura Kazuyoshi、Kashiwagi Kenji
    • Journal Title

      Journal of Ophthalmology

      Volume: 2017 Pages: 1-6

    • DOI

      10.1155/2017/7642049

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice2017

    • Author(s)
      Kashiwagi Kenji、Ito Sadahiro、Maeda Shuichiro、Kato Goro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-017-16872-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy of predetermined therapeutic measures against bleb-related infection in the Collaborative Bleb-related Infection Incidence and Treatment Study2017

    • Author(s)
      Shoji Nobuyuki、Arakaki Yoshikuni、Nakamoto Kenji、Yamamoto Tetsuya、Kuwayama Yasuaki、The Collaborative Bleb-related Infection Incidence and Treatment Study Group
    • Journal Title

      Acta Ophthalmologica

      Volume: 96 Issue: 2

    • DOI

      10.1111/aos.13523

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 正常ボランティアにおける乳頭周囲血管密度、Flux Indexに影響する因子についての検討2020

    • Author(s)
      津村 豊明, 小倉 拓, 黒川 由加, 秋山 麗, 柏木 賢治
    • Organizer
      第124回日本眼科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 当院におけるMIGSの中長期成績の比較検討2020

    • Author(s)
      北村 一義, 柏木 賢治
    • Organizer
      第124回日本眼科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 2020年に考える日本医療のグランドデザインと眼科 これからの日本における眼科診療のリアルワールド2020

    • Author(s)
      柏木 賢治
    • Organizer
      第124回日本眼科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] AI時代をどう生きるか 日本における眼科AI・ビッグデータの現状2020

    • Author(s)
      柏木 賢治
    • Organizer
      第124回日本眼科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 次世代眼科医療を目指す、ICT/人工知能を活用した画像等データベースの基盤構築プロジェクト、システム構築報告(第二報)2019

    • Author(s)
      長谷川 高志, 柏木 賢治, 三宅 正裕, 坂本 泰二, 大鹿 哲郎, 福重 秀文, 井上 仁, 宇都木 仁, 本郷 勝義, 南 常治, 畑中 正行
    • Organizer
      第39回医療情報学連合大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 『標準化』の活用-システムの接続からBig dataの時代へ- 緑内障におけるデータ標準化とビッグデータの活用2019

    • Author(s)
      柏木 賢治
    • Organizer
      第39回医療情報学連合大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自己測定型眼圧計と外来ゴールドマン圧平式眼圧計の関連性2019

    • Author(s)
      長谷部 優花, 北村 一義, 柏木 賢治
    • Organizer
      第30回日本緑内障学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 緑内障の進行リスクと生活リスク 緑内障診療における遺伝子とビッグデータの活用とその課題2019

    • Author(s)
      柏木 賢治
    • Organizer
      第30回日本緑内障学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Trabectome手術の中長期成績の検討2019

    • Author(s)
      北村 一義, 柏木 賢治
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] AIとビッグデータがもたらす眼科医療の将来 次世代眼科医療を目指すICT/人工知能を活用した画像等データベースの基盤構築2019

    • Author(s)
      柏木 賢治
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 難治性ネフローゼ症候群に対するステロイド中止後に急激な進行を呈した白内障の1例2019

    • Author(s)
      渡邊 大輔, 沢登 恵美, 金井 宏明, 小林 杏奈, 後藤 美和, 北村 一義, 柏木 賢治, 東田 耕輔, 犬飼 岳史
    • Organizer
      第123回日本小児科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] パラダイムシフトを迎えた医療情報社会における眼科のリアルワールドを考える 緑内障治療を中心に2019

    • Author(s)
      柏木 賢治
    • Organizer
      第83回日本眼科臨床学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 糖尿病黄斑浮腫発症に関連する全身、眼局所要因の検討2017

    • Author(s)
      久米 淳貴, 大城 智洋, 櫻田 庸一, 柏木 賢治
    • Organizer
      日本眼科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Srcセリン75のリン酸化は加齢性網膜神経節細胞数に影響する2017

    • Author(s)
      柏木 賢治, 加藤 梧郎
    • Organizer
      日本眼科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 創薬に必要な眼科のドラッグデリバリーシステム(DDS) 新しい緑内障治療に向けたDDSの在り方2017

    • Author(s)
      柏木 賢治
    • Organizer
      日本眼科学会総会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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