Therapeutic use of new biomaterial base on the nanotechnology for the treatment of chronic wounds

• Project/Area Number: 17K11546
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Saitama Medical University
• Principal Investigator: Shigeru Ichioka 埼玉医科大学, 医学部, 教授 (60306272)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 創傷治癒 / 創傷

Outline of Final Research Achievements

Three major components of regenerative medicine include cell, signal molecule and scaffold. This study aims at developing comprehensive wound management system
integrating regenerative biotechnology and physical therapy. Thus far, we　have estimated the efficacy of our original biomaterial in vivo.

Academic Significance and Societal Importance of the Research Achievements

再生医療の分野は、創傷治癒でも有用な手段となりつつある。形成外科医は、臨床の場で人工真皮という足場を用いて、創傷治療を行なっている。既存の足場のみならず我々は、ポリグリコール酸を使用したナノファイバーの足場(PGA/collagen)を開発し、その有効性を示した。

Research Products

• [Journal Article] Reconstruction for labial adhesion in postmenopausal woman using vulvoperineal flap. (2019)
  • Author(s): Takimoto M, Sato T, Ichioka S.
  • Journal Title: Case Reports Plast Surg Hand Surg. Volume: 23 Issue: 1 Pages: 136-139
  • DOI: 10.1080/23320885.2019.1602474
  • Peer Reviewed
• [Journal Article] Hydrosurgical debridement as an approach to wound healing: an animal thermal burn model. (2019)
  • Author(s): Hirokawa E, Sato T, Fujino T, Gotoh Y, Yokogawa H, Ichioka S.
  • Journal Title: J Wound Care Volume: 28 Pages: 304-311
  • Peer Reviewed
• [Journal Article] 遊離皮弁移植による創閉鎖 (2019)
  • Author(s): 石川昌一 市岡滋
  • Journal Title: 形成外科 Volume: 62 Pages: 49-58
• [Journal Article] Hyperbaric oxygen therapy for digital ulcers due to Raynaud's disease. (2018)
  • Author(s): Sato T, Arai K, Ichioka S.
  • Journal Title: Case Reports Plast Surg Hand Surg Volume: 25 Pages: 72-74
  • Peer Reviewed
• [Journal Article] Factors impairing cell proliferation in the granulation tissue of pressure ulcers: Impact of bacterial burden. (2018)
  • Author(s): Sato T, Abe T, Ichioka S.
  • Journal Title: Wound Repair Regen Volume: 26 Pages: 284-292
  • Peer Reviewed
• [Journal Article] Free flap reconstruction for diabetic foot limb salvage. (2017)
  • Author(s): Sano H, Ichioka S
  • Journal Title: J Plast Surg Hand Surg. Volume: 13 Issue: 6 Pages: 1-6
  • DOI: 10.1080/2000656x.2017.1285782
  • Peer Reviewed
• [Presentation] 創傷評価の方法 (2019)
  • Author(s): 市岡 滋
  • Organizer: 第1１回日本下肢救済・足病学会
  • Invited
• [Presentation] 創傷治療：最近の話題 (2019)
  • Author(s): 市岡 滋
  • Organizer: 第16回日本褥瘡学会関東甲信越地方会学術集会
  • Invited
• [Presentation] 難治性皮膚潰瘍形成外科の立場から (2018)
  • Author(s): 市岡滋
  • Organizer: 第82回日本皮膚科学会東京支部学術大会
  • Invited
• [Presentation] 局所陰圧閉鎖療法とは (2018)
  • Author(s): 市岡滋
  • Organizer: 第48回 日本創傷治癒学会
• [Presentation] 創傷治癒学からのメッセージ 難治性創傷治療の最新情報 (2018)
  • Author(s): 市岡滋
  • Organizer: 第73回日本大腸肛門病学会学術集会
  • Invited
• [Presentation] 褥瘡学会の20年 (2018)
  • Author(s): 市岡滋
  • Organizer: 第20回日本褥瘡学会学術集会
  • Invited
• [Presentation] 形成外科医が医工学といかに関わったか (2017)
  • Author(s): 市岡滋
  • Organizer: 第15回日本フットケア学会年次学術集会
  • Invited