Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Outline of Final Research Achievements |
This study investigated the neuroprotective effects of the mammalian target of rapamycin (mTOR) on the early brain injury in the murine model of subarachnoid hemorrhage. We studied aged mice (80-90 weeks) as a model of the pathology of the elderly. Briefly, we confirmed that the mTOR has a therapeutic effect on enhanced recovery from decreased cerebral blood flow and locomotor activity after the induction of SAH. Further, our results showed that the mTOR inhibits the increased number of glial cells after the ischemic injury. These findings provide basic information regarding the neuroprotective role of mTOR against microvascular ischemic injury after SAH in the aged brain.
|