| Project/Area Number |
17K11587
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
NEGI SHIGEO 和歌山県立医科大学, 医学部, 准教授 (20208284)
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| Co-Investigator(Kenkyū-buntansha) |
重松 隆 和歌山県立医科大学, 医学部, 教授 (30187348)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 急性腎障害 / 水素 / 虚血再灌流 / ラット / 虚血再灌流障害 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the mechanism that hydrogen can prevent and ameliorate AKI in AKI due to ischemia-reperfusion injury（IRI）. IRI-induced AKI model rats were divided into two groups , a hydrogen-administered group and a non-hydrogen-administered group(control group).Before IRI, 24hours, 48 hours, 72 hours, and 7 days after IRI , creatine（Cr） level and blood urea nitrogen（BUN） level were measured. Both peak Cr and BUN values were significantly higher in the hydrogen-administered group than in the control group(24 hours). The protective effect of hydrogen against IRI-induced AKI was not observed.
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| Academic Significance and Societal Importance of the Research Achievements |
水素によるAKIの予防効果や腎障害に対する軽減効果が証明できれば, 臨床において水素を用いてAKIの予防やAKIを発症した患者に対して治療薬として使用できる可能性があり, 予後改善が認められないAKI症例の予後改善につながることが期待できた。しかしながら, 今回の検討では水素によるAKIにおける腎障害の軽減効果は認められず, 水素をAKI患者の治療薬として使用することはできないと結論できる。
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