| Project/Area Number |
17K11823
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
Satoh Chiharu 北海道大学, 大学病院, 講師 (50222013)
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| Co-Investigator(Kenkyū-buntansha) |
菊地 奈湖 (間石奈湖) 北海道大学, 歯学研究院, 助教 (00632423)
大賀 則孝 北海道大学, 歯学研究院, 助教 (40548202)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 口腔がん / 腫瘍血管 / CXCR7 / 口腔癌 / ケモカインレセプター / 血管 / 口腔外科学一般 / 腫瘍血管内皮細胞 |
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| Outline of Final Research Achievements |
In this study, we investigated the relationship between the CXCR7 expression in tumor blood vessels of oral cancer and clinicopathological factors and prognosis to search the usefulness as a biomarker. CXCR7 expression was analyzed in tumor tissues of oral squamous cell carcinoma and their surrounding non-tumor area by immunohistochemistry. Blood vessels were visualized by CD34 immunostaining in the serial section to investigate the co-localization with CXCR7. CXCR7 was barely stained in blood vessels of non-tumor area, whereas it was stained in tumor blood vessels. The advanced cases were more in CXCR7 high group compared to the low group. Disease-free survival tended to lower in the high CXCR7 group than in the CXCR7 low group. These data suggested that CXCR7 in tumor blood vessels can be a prognosis factor.
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| Academic Significance and Societal Importance of the Research Achievements |
がんにおけるCXCR7発現については様々ながんで報告されつつあるが、口腔がんにおける腫瘍血管のCXCR7発現の意義についてはまだ報告はない。本研究により，口腔がん腫瘍血管でCXCR7の発現が亢進していること，それがステージなど臨床病理学的因子と関連があることが示唆された．さらに，腫瘍血管でCXCR7発現が高いと局所再発をきたす症例が多く，さらに無病生存率が低い傾向が示された．腫瘍血管におけるCXCR7発現が予後予測などバイオマーカーになり得る可能性が示唆された。
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