How is the nitrite contributing to our general and oral health promotion produced in oral microflora?
| Project/Area Number |
17K12003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
WASHIO JUMPEI 東北大学, 歯学研究科, 講師 (20400260)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 信博 東北大学, 歯学研究科, 教授 (60183852)
佐藤 拓一 新潟大学, 医歯学系, 教授 (10303132)
石黒 和子 東北大学, 歯学研究科, 大学院非常勤講師 (00755829)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 口腔細菌 / 代謝 / 亜硝酸 / 口腔細菌による硝酸代謝 / 口腔バイオフィルム / 硝酸還元活性 / 歯学 / 細菌 |
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| Outline of Final Research Achievements |
In recent years, it attracts attention that oral bacteria can metabolize nitrate included in yellow-green vegetables or saliva to nitrite, that has antibacterial activity and vasodilatation effect, and which may contribute to maintain our general and oral health.However, the details about the production of nitrite in the oral cavity is still unknown. Therefore, we tried to clarify the whole aspect of nitrite production in the oral cavity.
The nitrite-producing activity in the oral cavity was higher in dental plaque than tongue coatings. The interindividual differences was also higher. It was clarified that the bacterial species such as Actinomyces, Shaalia, and Veillonella species known as commensal bacteria mainly contribute to the nitrite production in oral cavity. In addition, it was also clarified that those nitrite-producing activity can be fluctuated by the various environmental factors such as an oxygen concentration, pH and the lactate concentration.
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| Academic Significance and Societal Importance of the Research Achievements |
亜硝酸塩は、その抗菌作用による口腔疾患の予防効果と、全身の血液拡張効果を通した循環器疾患予防効果に注目が集まっており、「口腔内細菌の代謝活動が口腔・全身の“健康”と関わる」という視点でのさらなる研究展開が期待される。また、本研究の知見からは、口腔細菌による亜硝酸塩産生が主に常在菌によって行われ、さらに環境によりその産生活性が調節されうることが明らかとなったことから、それらを利用し、口腔・全身疾患の予防効果を高める方法の開発に寄与する可能性が考えられた。
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Report
(5 results)
Research Products
(76 results)
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[Journal Article] Bacterial amounts and compositions in liquid baby formula and a baby drink consumed with an artificial nipple.2021
Author(s)
Wakui A, Sano H, Kawachi M, Aida A, Takenaka Y, Yonezawa A, Nakahata N, Moriyama S, Nishikata M, Washio J, Abiko Y, Mayanagi G, Yamaki K, Sakashita R, Tanaka K, Takahashi N, Sato T
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Journal Title
J Oral Biosci.
Volume: 印刷中
Issue: 2
Pages: 161-168
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Profiling of Microbiota of Baby-Drinks after Drinking with Artificial Nipples2020
Author(s)
Wakui A, Sano H, Kawachi M, Masuda N, Maruyama S, Washio J, Abiko Y, Mayanagi G, Yamaki K, Takahashi N, Okada Y, Sato T
Organizer
,第62回歯科基礎医学会学術大会
Related Report
Invited
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[Presentation] Metabolomics of Oral Microbiome2019
Author(s)
Washio J, Abiko Y, Dimas Prasetianto Wicaksono, Yamamoto Y, Takahashi N
Organizer
4th Asia Pacific Regional Congress of the International Association for Dental Research
Related Report
Int'l Joint Research / Invited
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[Presentation] Profiling of Microbiota of Baby-Drinks after Drinking with Artificial Nipples.2018
Author(s)
Wakui A, Sano H, Aihara H, Kawachi M, Takahashi A, Washio J, Abiko Y, Mayanagi G, Ishiguro K, Yamaki K, Takahashi N, Sato T
Organizer
JADR2018/ 66th Japanese Division Meeting 2018
Related Report
Int'l Joint Research
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[Presentation] A novel method to screen and isolate nitrate-producing bacteria from the oral cavity2018
Author(s)
Washio J, Suzuki Y, Dimas Prasetianto Wicaksono, Ishiguro K, Nishino M, Otake T, Sasaki S, Tadokoro S, Takahashi S, Ishiguro K, Takahashi N
Organizer
International Symposium for Multimodal research and Education in IOHS-Liaison 2018
Related Report
Int'l Joint Research
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[Presentation] Microbiota Profiling at the Mouth of Plastic Bottles after Drinking Straight from Bottles.2018
Author(s)
Sano H, Aida A, Vidanapathirana G.U., Wakui A, Takenaka Y, Kawachi M, Aihara H, Washio J, Abiko Y, Mayanagi G, Ishiguro K, Yamaki K, Takahashi N, Sato T
Organizer
International Symposium for Multimodal research and Education in IOHS-Liaison 2018
Related Report
Int'l Joint Research
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