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Elucidation of the onset mechanism and establishment of the prevention protocol in children with drug-induced gingival hyperplasia undergoing immunosuppressive therapy

Research Project

Project/Area Number 17K12026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

Shimazu Kisaki  日本歯科大学, 生命歯学部, 非常勤講師 (80582254)

Co-Investigator(Kenkyū-buntansha) 高橋 幸裕  日本歯科大学, 生命歯学部, 教授 (00281436)
島津 徳人  麻布大学, 生命・環境科学部, 准教授 (10297947)
苅部 洋行  日本歯科大学, 生命歯学部, 教授 (50234000)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords免疫抑制剤 / 薬物性歯肉増殖症 / 口腔内細菌 / PCR / シクロスポリン / 歯肉増殖症
Outline of Final Research Achievements

The immunosuppressive drug cyclosporine is used to prevent graft rejection after organ transplantation and treat nephrotic syndrome. Despite its high therapeutic efficacy, it causes many problematic side effects. This study aimed to establish a method for identifying plaque bacteria in pediatric patient samples, to elucidate the difference in the plaque bacteria by presence of cyclosporine taking.
We established a method for identifying plaque bacteria in pediatric patient samples using PCR. We intend to carry out further studies with more subjects to compare the differences in oral bacterial layers of individuals taking cyclosporine and patients with gingival proliferation, and determine the association between the development of side effects and presence of certain bacteria.

Academic Significance and Societal Importance of the Research Achievements

免疫抑制剤シクロスポリンの服用が起因となる歯肉増殖症の発症メカニズムについては、これまでに多くの研究者によって検討されているが、口腔内細菌と薬物性歯肉増殖との関連はいまだ明らかとなっておらず、シクロスポリン服用小児における報告は皆無である。本研究では、薬物性歯肉増殖症の発症率が成人の約3倍である小児に焦点をあて、小児被験者から採取したプラーク細菌をPCR により同定する方法を確立でき、シクロスポリン服用の有無で口腔細菌の違いが認められたことは有意義である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2020 2019 2018 2017 Other

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 5 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Influence of artificial saliva contamination on adhesion in class V restorations2020

    • Author(s)
      SHIMAZU Kisaki、KARIBE Hiroyuki、OGUCHI Riyo、OGATA Kiyokazu
    • Journal Title

      Dental Materials Journal

      Volume: 39 Issue: 3 Pages: 429-434

    • DOI

      10.4012/dmj.2019-032

    • NAID

      130007852255

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2020-05-27
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gender differences in adolescents’ perceptions toward dentists using the Japanese version of the dental beliefs survey: a cross-sectional survey2019

    • Author(s)
      Hiroyuki Karibe, Yuichi Kato, Kisaki Shimazu, Ayuko Okamoto, Masahiro Heima
    • Journal Title

      BMC Oral Health

      Volume: 19 Issue: 1 Pages: 144-144

    • DOI

      10.1186/s12903-019-0845-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contribution of <i>Streptococcus gordonii</i> Hsa Adhesin to Biofilm Formation2017

    • Author(s)
      Oguchi R, Takahashi Y, Shimazu K, Urano-Tashiro Y, Kawarai T, Konishi K, Karibe H
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 70 Issue: 4 Pages: 399-404

    • DOI

      10.7883/yoken.JJID.2016.492

    • NAID

      130005851925

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Identification of oral periodontal bacteria by PCR methods in children with drug-induced gingival hyperplasia2019

    • Author(s)
      Shimazu K, Takahashi Y, Oguchi R, Ogata K, Shimazu Y, Karibe H
    • Organizer
      Int. J. Paediatr. Dent.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 免疫抑制剤服用小児における薬物性歯肉増殖の微生物学的解析2019

    • Author(s)
      島津貴咲,高橋幸裕,小口莉代,小方清和,三井園子,五十川伸崇,苅部洋行
    • Organizer
      日本障害者歯科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of oral bacteria in children with drug-induced gingival hyperplasia undergoing immunosuppressive therapy2018

    • Author(s)
      Kisaki Shimazu, Yukihiro Takahashi, Kiyokazu Ogata, Yoshihito Shimazu, Hiroyuki Karibe
    • Organizer
      J. of Disability and Oral Health.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detection of Streptococcus gordonii Hsa gene and expression of Hsa adhesin in wild type strains2017

    • Author(s)
      8.Takahashi Y, Oguchi R, Shimazu K, Tashiro Y, Kawarai T, Karibe H, Konishi K
    • Organizer
      15th International congress of bacteriology and applied microbiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Geographical differences in orofacial pain conditions and daily activities in Japanese children2017

    • Author(s)
      Karibe H, Okamoto A, Shimazu K, Kawakami T
    • Organizer
      Int J Paediatr Dent
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Goddard G. Inter-examiner and intra-examiner reliability of gag reflex measurement2017

    • Author(s)
      Karibe H, Okamoto A, Kato Y, Shimazu K
    • Organizer
      31st IADR-SEA & 28th SEAADE
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 子どもの歯科訪問診療 実践ガイド 他職種と連携して小児在宅歯科医療をはじめよう2019

    • Author(s)
      小方清和、田村文誉、小坂美樹、横山雄士、島津貴咲、三井園子、百瀬智彦、小口莉代、他
    • Total Pages
      155
    • Publisher
      医歯薬出版株式会社
    • ISBN
      9784263445495
    • Related Report
      2019 Annual Research Report
  • [Remarks] 日本歯科大学小児歯科学講座ホームページ

    • URL

      http://www.ndu.ac.jp/~pedo/researchoutline.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 日本歯科大学生命歯学部 小児歯科学講座

    • URL

      http://www.ndu.ac.jp/~pedo/

    • Related Report
      2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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