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Study on the relationship between intraoral colonization of periodontopathic bacteria and oral condition in young people

Research Project

Project/Area Number 17K12036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKansai Women's Junior College

Principal Investigator

Nagata Hideki  関西女子短期大学, その他部局等, 教授 (50260641)

Co-Investigator(Kenkyū-buntansha) 畠中 能子  関西女子短期大学, その他部局等, 教授 (00281577)
木村 重信  関西女子短期大学, その他部局等, 教授 (10177917)
花谷 早希子  関西女子短期大学, その他部局等, 准教授 (20435308)
大岡 知子  関西女子短期大学, その他部局等, 教授 (30352991)
関根 伸一  大手前短期大学, その他部局等, 教授 (70506344)
Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords歯周病原細菌 / 唾液 / DMF歯数 / プラーク / PMA Index / 歯周病原性細菌
Outline of Final Research Achievements

Saliva samples of 30 young female subjects (18- to 21-year-old) were analyzed for the presence of peridontopathic bacteria using PCR and real-time PCR methods. Porphyromonas gingivalis was detected in fifteen samples (50.0%), Prevotella intermedia was detected in 4 samples (13.3%), and Aggregatibacter actinomycetemcomitans was detected in only one sample (5%). The cell count of the detected bacteria was very few in each subject (less than 0.01% of total bacterial count).
Twenty subjects were recieved oral examination including number of DMF teeth, CPI, plaque score, and PMA index. There was no significant relationship between detection rate of the periodontopathic bacteria and oral conditions. However, a trend was seen in that detection rate of P. gingivalis in subjects with high plaque score was higher than that in subjects with low plaque score.

Academic Significance and Societal Importance of the Research Achievements

本研究課題は、歯周病原細菌の口腔内定着時期について検討するため、若年者を対象に歯周病原細菌の定着率を調べ、歯周病原細菌の種類により定着率が異なることを報告した。また、Pophyromonas gingivalisの定着はプラークの付着量と関連する可能性があることを示唆した。
種々の歯周病原細菌の感染時期や定着率が明らかとなれば、ライフステージを考慮した歯周病予防対策が可能となり、新たな歯周病予防法の開発につながるものと考えられる。さらに、歯周病は歯の喪失の最大の原因であり、全身疾患との関連も報告されていることから、健康寿命の延伸やQOLの向上にも寄与するものと考える。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (40 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (17 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 15 results,  Open Access: 5 results) Presentation (22 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Effect of <i>Q</i>-switched Er:YAG laser irradiation on bonding performance to dentin surface2022

    • Author(s)
      Kasakawa A, Sekine S, Tanaka K, Murakami J, Kondo S, Hazama H, Awazu K, Akiyama S.
    • Journal Title

      Dental Materials Journal

      Volume: 41 Issue: 4 Pages: 616-623

    • DOI

      10.4012/dmj.2021-281

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2022-07-25
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Onset of cervico-omo-brachial disorder among dental hygienist students during off-campus clinical training and its relationship with working posture2021

    • Author(s)
      花谷 早希子、大岡 知子、畑田 晶子、畠中 能子、濱元 一美、細見 環、新井 佐和、岡橋 祐、木村 重信
    • Journal Title

      関西女子短期大学紀要

      Volume: 31 Issue: 31 Pages: 45-53

    • DOI

      10.24614/00003301

    • NAID

      120007168986

    • ISSN
      09179461
    • URL

      https://fuksi-kagk-u.repo.nii.ac.jp/records/3439

    • Year and Date
      2021-10-07
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of gum chewing on the sleeping by students during classes and its relationship with their sleeping time the night before2021

    • Author(s)
      畑田 晶子、永田 英樹、花谷 早希子、古賀 恵、新井 麻実、中本 千朱佳、谷本 愛沙未、木村 重信、大嶋 隆
    • Journal Title

      関西女子短期大学紀要

      Volume: 31 Issue: 31 Pages: 33-38

    • DOI

      10.24614/00003286

    • NAID

      120007148752

    • ISSN
      09179461
    • URL

      https://fuksi-kagk-u.repo.nii.ac.jp/records/3424

    • Year and Date
      2021-09-22
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 口腔ケアと健康食品2021

    • Author(s)
      永田英樹
    • Journal Title

      日本食品安全協会会誌

      Volume: 16 Pages: 155-160

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 歯周病をターゲットとした口腔保健用機能性食品素材2021

    • Author(s)
      永田英樹
    • Journal Title

      食と医療

      Volume: 17 Pages: 39-45

    • Related Report
      2021 Research-status Report
  • [Journal Article] Multiplex amplification of target genes of periodontal pathogens in continuous flow PCR microfluidic chip2021

    • Author(s)
      Li Zhenqing、Liu Jiahui、Wang Ping、Tao Chunxian、Zheng Lulu、Sekine Shinichi、Zhuang Songlin、Zhang Dawei、Yamaguchi Yoshinori
    • Journal Title

      Lab on a Chip

      Volume: 21 Issue: 16 Pages: 3159-3164

    • DOI

      10.1039/d1lc00457c

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibitory effects of curcumin against cytotoxicity of Porphyromonas gingivalis outer membrane vesicles2021

    • Author(s)
      Izui Shusuke、Sekine Shinichi、Murai Hiroki、Takeuchi Hiroki、Amano Atsuo
    • Journal Title

      Archives of Oral Biology

      Volume: 124 Pages: 105058-105058

    • DOI

      10.1016/j.archoralbio.2021.105058

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contribution of different adherent properties of <i>Granulicatella adiacens</i> and <i>Abiotrophia defectiva</i> to their associations with oral colonization and the risk of infective endocarditis2020

    • Author(s)
      Sasaki Minoru、Shimoyama Yu、Ishikawa Taichi、Kodama Yoshitoyo、Tajika Shihoko、Kimura Shigenobu
    • Journal Title

      Journal of Oral Science

      Volume: 62 Issue: 1 Pages: 36-39

    • DOI

      10.2334/josnusd.19-0021

    • NAID

      130007791543

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization and pathogenicity of fibronectin binding protein FbpI of Streptococcus intermedius2020

    • Author(s)
      Kodama Yoshitoyo、Shimoyama Yu、Ishikawa Taichi、Kimura Shigenobu、Sasaki Minoru
    • Journal Title

      Archives of Microbiology

      Volume: 202 Issue: 8 Pages: 2071-2081

    • DOI

      10.1007/s00203-020-01922-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tyrosine tRNA synthetase as a novel extracellular immunomodulatory protein in Streptococcus anginosus2020

    • Author(s)
      Shimoyama Yu、Ishikawa Taichi、Kodama Yoshitoyo、Kimura Shigenobu、Sasaki Minoru
    • Journal Title

      FEMS Microbiology Letters

      Volume: 367 Issue: 18

    • DOI

      10.1093/femsle/fnaa153

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 某養護老人ホームでの歯科衛生士による口腔保健介入効果 第二報2019

    • Author(s)
      畑田晶子,花谷早希子,古賀 恵,新井麻実,濵元一美,大岡知子,畠中能子
    • Journal Title

      大阪府歯科衛生士会 学術誌

      Volume: 29 Pages: 18-19

    • Related Report
      2019 Research-status Report
  • [Journal Article] All-in-one microfluidic device for on-site diagnosis of pathogens based on an integrated continuous flow PCR and electrophoresis biochip2019

    • Author(s)
      Li Zhenqing、Ju Ruixue、Sekine Shinichi、Zhang Dawei、Zhuang Songlin、Yamaguchi Yoshinori
    • Journal Title

      Lab on a Chip

      Volume: 19 Issue: 16 Pages: 2663-2668

    • DOI

      10.1039/c9lc00305c

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7, and DPP11 in human oral microbiota ? potent biomarkers indicating presence of periodontopathic bacteria2018

    • Author(s)
      Ohara-Nemoto Yuko、Shimoyama Yu、Nakasato Manami、Nishimata Haruka、Ishikawa Taichi、Sasaki Minoru、Kimura Shigenobu、Nemoto Takayuki K
    • Journal Title

      FEMS Microbiology Letters

      Volume: 365 Pages: 1-7

    • DOI

      10.1093/femsle/fny221

    • NAID

      120006987966

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of HACEK Group Bacteria from Blood Samples of Patients with Infective Endocarditis by PCR-RFLP of the 16s rRNA Gene2018

    • Author(s)
      Sasaki Minoru、Ishikawa Taichi、Shimoyama Yu、Kodama Yoshitoyo、Tajika Shihoko、Kimura Shigenobu
    • Journal Title

      Research Journal of Microbiology

      Volume: 13 Issue: 2 Pages: 93-99

    • DOI

      10.3923/jm.2018.93.99

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Precise and simultaneous enumeration of multiplex pathogens using multiplex polymer chain reaction coupled with a novel quantitative capillary electrophoresis2018

    • Author(s)
      Liu Chenchen、Yamaguchi Yoshinori、Sekine Shinichi、Ni Yi、Dou Xiaoming
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 258 Pages: 263-269

    • DOI

      10.1016/j.snb.2017.11.106

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alignment and counting of mitochondria based on capillary electrophoresis2018

    • Author(s)
      Li Zhenqing、Yang Bo、Sekine Shinichi、Zhuang Songlin、Zhang Dawei、Yamaguchi Yoshinori
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 265 Pages: 110-114

    • DOI

      10.1016/j.snb.2018.03.032

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study2018

    • Author(s)
      Choi Youn-Hee、Kosaka Takayuki、Ojima Miki、Sekine Shinichi、Kokubo Yoshihiro、Watanabe Makoto、Miyamoto Yoshihiro、Ono Takahiro、Amano Atsuo
    • Journal Title

      BMC Oral Health

      Volume: 18 Issue: 1 Pages: 77-77

    • DOI

      10.1186/s12903-018-0536-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 成人健常者の舌圧と握力との関連性2022

    • Author(s)
      畑田晶子、脇坂 聡、永田英樹、濵元一美、西原佐和、岡橋 祐、花谷早希子、木村重信
    • Organizer
      日本歯科衛生学会 第17回学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 臨床実習前の歯科衛生学生の身体疲労2022

    • Author(s)
      花谷早希子、細見 環、畠中能子、大岡知子、古賀 恵、新井麻実、谷本愛沙未、畑田晶子、木村重信
    • Organizer
      日本歯科衛生学会 第17回学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 歯科衛生学教育コア・カリキュラム―教育内容ガイドライン―2022年度改訂版発行にあたり2022

    • Author(s)
      高阪利美、合場千佳子、大川由一、池田理恵、白鳥たかみ、山田小枝子、犬飼順子、升井一朗、畠中能子、日野出大輔
    • Organizer
      第13回日本歯科衛生教育学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 研究者のための論文の書き方講習-今日から使える質向上のイロハとはPart III- 論文投稿準備と査読結果への対応について2021

    • Author(s)
      永田英樹
    • Organizer
      第70回日本口腔衛生学会・総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 歯科衛生士学生の特性的自己効力感の検討2021

    • Author(s)
      新井麻実,畠中能子,古賀 恵,岡橋 祐,脇坂 聡
    • Organizer
      日本歯科衛生学会,第16回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 新型コロナウイルス感染症の流行に伴う歯科衛生士学生に対する学外実習の試み―障がい者施設での訪問歯科診療に関する実習の場合-2021

    • Author(s)
      濵元一美,新井麻実,古賀 恵,畑田晶子,花谷早希子
    • Organizer
      第62回日本歯科医療管理学会総会・学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 成人のオーラルフレイルに関わる口腔機能の実態2021

    • Author(s)
      畑田晶子,永田英樹,濵元一美,新井佐和,大西宏昭,大嶋 隆
    • Organizer
      日本歯科衛生学会,第16回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] スケーリング操作時の不良姿勢割合2021

    • Author(s)
      花谷早希子,大岡知子,細見 環,谷本愛沙未,木村重信
    • Organizer
      日本歯科衛生学会,第16回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 歯科衛生士養成校3校における学生の社会人基礎力に対する臨床実習の効果2021

    • Author(s)
      古賀 恵,神 光一郎,畠中能子,花谷早希子,畑田晶子,谷本愛沙未,新井佐和,岡橋 祐,木村重信,大嶋 隆
    • Organizer
      第12回日本歯科衛生教育学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 某養護老人ホームでの歯科衛生士による口腔健康管理の効果2020

    • Author(s)
      畑田晶子、小田見也子、品田和子、椿本雅宥、永田英樹、大島 隆
    • Organizer
      日本歯科衛生学会第15回学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 女子大学生における肥満予防のための食事法の検討2020

    • Author(s)
      小川由紀子,高尾理樹夫,川上由紀子,矢澤彩香,山下絵美,江﨑ひろみ,畠中能子,吉田幸恵
    • Organizer
      日本歯科衛生学会第15回学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 歯科衛生士教員の研究状況と歯科衛生研究に関する要望2020

    • Author(s)
      石川裕子,高阪利美,畠中能子,合場千佳子
    • Organizer
      第11回日本歯科衛生教育学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 某養護老人ホームでの歯科衛生士による口腔保健介入 第二報.2020

    • Author(s)
      7.畑田晶子,花谷早希子,古賀 恵,新井麻実,濵元一美,大岡知子,畠中能子
    • Organizer
      第25回大阪府歯科衛生士会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Streptococcus anginosus 菌体外タンパク質抗原によるマクロファージ活性化機構の解析2019

    • Author(s)
      1.Shimoyama, Y., Ishikawa, T., Kodama, Y., Kimura, S., and Sasaki, M., and Kimura, S.
    • Organizer
      第92回日本細菌学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effect of photodynamic therapy using 5-aminolevulinic acid on&nbsp;Porphyromonas gingivalis.2019

    • Author(s)
      Tanaka K, Sekine S, Taniguchi-Kasakawa A.
    • Organizer
      Asia Association for Disability and Oral Health 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 障害者の歯周病リスク判定における歯周病菌検出装置の活用2019

    • Author(s)
      鬼頭 昭吉, 関根 伸一, 森田 剛敏, 川原 康秀, 岡 雅子, 牧野 仁志, 村上 旬平, 秋山 茂久.
    • Organizer
      第36回日本障害者歯科学会総会および学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] PCR法を用いた新規歯周病菌測定装置の開発2018

    • Author(s)
      泉井秀介、関根伸一、天野敦雄
    • Organizer
      第67回日本口腔英英学会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 歯周病細菌に対する5ALAを用いたPDTの効果の検討2018

    • Author(s)
      関根伸一、泉井秀介、天野敦雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] PCR法を用いた歯周病菌Porphyromonas gingivalis検出装置の開発2018

    • Author(s)
      辻勇輔、下倉敏裕、関根伸一
    • Organizer
      第61回秋季日本歯周病学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 歯科衛生士学生における口腔機能評価結果からの一考察-オーラルディアドコキネシスとRSSTとの関連性-2018

    • Author(s)
      濵元一美、池田真己、中上久美子、花谷早希子、畑田晶子、神崎亘
    • Organizer
      第25回日本歯科医療福祉学会大会および総会
    • Related Report
      2018 Research-status Report
  • [Presentation] PCR法を用いた新規歯周病菌測定装置の開発2018

    • Author(s)
      泉井秀介、関根伸一、天野敦雄
    • Organizer
      第67回日本口腔衛生学会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 女子短期大学生のパノラマエックス線画像の検討-乳歯の晩期残存と後継永久歯の先天欠如あるいは埋伏について-2017

    • Author(s)
      花谷早希子、細見環、畠中能子、畑田晶子、中本千朱佳、木村重信、大嶋隆
    • Organizer
      第8回日本歯科衛生教育学会総会・学術大会
    • Related Report
      2017 Research-status Report
  • [Book] 文献ベースで歯科臨床の疑問に答えるチェアサイドQ&A予防歯科編2018

    • Author(s)
      永田英樹(於保孝彦監著、予防歯科臨床教育協議会編著)
    • Total Pages
      119
    • Publisher
      クインテッセンス出版
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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