The effects of exercise therapy on frontotemporal dementia

• Project/Area Number: 17K13218
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: Nemoto Miyuki 筑波大学, 医学医療系, 講師 (80754316)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 前頭側頭型認知症 / 運動療法 / 行動異常 / fNIRS

Outline of Final Research Achievements

The purpose of this study was to clarify the effects and mechanisms of exercise therapy on behavioral abnormalities in FTD (frontotemporal dementia) and to develop new treatments and support strategies for FTD. The results of the exercise intervention study for FTD suggested that exercise has a positive effect on psychological and physical functions of FTD. In addition, In addition, the habitual exercise tended to suppress the stereotyped behavior that is problematic in FTD.

Academic Significance and Societal Importance of the Research Achievements

FTD に対する非薬物療法は現時点でほぼ皆無であり、本研究の運動介入が示した結果は、FTD に対する非薬物療法の第一の手段として大きな役割を果たすことが期待できる。今後、さらに多数例を用いた研究、検討によりその有用性を確認する予定である。本研究はFTD に対する新たな治療戦略に資する、社会的貢献度の高い、意義ある研究であると考える。

Research Products

• [Journal Article] The Multicomponent Day-Care Program Prevents Volume Reduction in a Memory-Related Brain Area in Patients with Mild Cognitive Impairment (2022)
  • Author(s): Boku Youshun、Ota Miho、Nemoto Miyuki、Numata Yuriko、Kitabatake Ayako、Takahashi Takumi、Nemoto Kiyotaka、Tamura Masashi、Sekine Aya、Ide Masayuki、Kaneda Yuko、Arai Tetsuaki
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: - Issue: 2 Pages: 1-8
  • DOI: 10.1159/000522654
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Exercise for Enhancing Visuospatial Ability in Older Adults with Frailty: Development, Feasibility, and Effectiveness (2020)
  • Author(s): Nemoto Miyuki、Sasai Hiroyuki、Yabushita Noriko、Tsuchiya Keito、Hotta Kazushi、Fujita Yoshihiko、Kim Taeho、Tsujimoto Takehiko、Arai Tetsuaki、Tanaka Kiyoji
  • Journal Title: Geriatrics Volume: 5 Issue: 2 Pages: 29-29
  • DOI: 10.3390/geriatrics5020029
  • Peer Reviewed / Open Access
• [Journal Article] 院内型フレイル対策～メンタルフレイルの視点から～ (2018)
  • Author(s): 根本みゆき、新井哲明
  • Journal Title: 介護予防・健康づくり Volume: 5 Pages: 78-81
• [Journal Article] 高齢期のダンス実践が認知機能と主観的健康観に及ぼす効果 (2017)
  • Author(s): 三宅 眞理, 根本 みゆき, 藪下 典子, 小澤 多賀子, 三島 伸介, 西山 利正, 田中 喜代次
  • Journal Title: 日本認知症予防学会誌 Volume: 7 Pages: 27-35
  • Peer Reviewed
• [Journal Article] 認知症に対する運動療法 (2017)
  • Author(s): 根本みゆき, 田中喜代次, 新井哲明
  • Journal Title: 介護福祉・健康づくり Volume: 4 Pages: 139-142
• [Presentation] Longitudinal effect of participation in a multimodal program for patients with mild cognitive impairment: an analysis of five data points over a period of 2 years (2018)
  • Author(s): Miyuki Nemoto, Kiyotaka Nemoto, Shinji Higashi, Eriko Tsukada, Miho Ota, Ryohei Watanabe, Yuko Kaneda, Tomoko Takeuchi, Takashi Asada, Tetsuaki Arai
  • Organizer: Alzheimer’s Association International Conference
  • Int'l Joint Research
• [Book] アルツハイマー病治療の新たなストラテジー (2022)
  • Author(s): 岩田淳・橋本衛・編、part6分著：根本みゆき、根本清貴、新井哲明
  • Total Pages: 149
  • Publisher: 先端医学社
  • ISBN: 9784865505405