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Control of TGF-beta related protein based on selective photooxygenation

Research Project

Project/Area Number 17K13260
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomolecular chemistry
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Taniguchi Atsuhiko  東京薬科大学, 薬学部, 講師 (30790125)

Research Collaborator HAYASHI Yoshio  
TAKAYAMA Kentaro  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords光酸素化 / 触媒 / ペプチド / マイオスタチン / 生体分子の化学修飾
Outline of Final Research Achievements

Myostatin, one of the transforming growth factor-beta (TGF-beta) superfamily proteins, negatively regulates a growth of muscle mass. In this study, a conjugate which is composed of myostatin-binding peptide and photo-oxygenation catalyst was developed, and the conjugate successfully induced myostatin-selective photo-oxygenation. Moreover, the oxygenation drastically inhibited the activity of myostatin.

Academic Significance and Societal Importance of the Research Achievements

TGF-β (transforming growth factor-β:トランスフォーミング増殖因子β)スーパーファミリーに属するマイオスタチンは、筋肉の増殖を抑制する活性をもつ。本研究では、マイオスタチンを選択的に光酸素化し、不活化する分子を創製した。このマイオスタチン阻害法は、筋肉量を増大し、筋ジストロフィーや老年性筋萎縮等の筋萎縮性疾患に対する新しい治療法になる可能性がある。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (18 results) (of which Int'l Joint Research: 6 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs2019

    • Author(s)
      Taniguchi Atsuhiko、Sawazaki Taka、Shimizu Yusuke、Sohma Youhei、Kanai Motomu
    • Journal Title

      MedChemComm

      Volume: 印刷中 Issue: 7 Pages: 1121-1125

    • DOI

      10.1039/c9md00011a

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amyloid-selective Photooxygenation toward Treatment for Amyloid Diseases2018

    • Author(s)
      Taniguchi Atsuhiko
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 138 Issue: 1 Pages: 47-53

    • DOI

      10.1248/yakushi.17-00186-2

    • NAID

      130006300834

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2018-01-01
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide2018

    • Author(s)
      Ni Jizhi、Taniguchi Atsuhiko、Ozawa Shuta、Hori Yukiko、Kuninobu Yoichiro、Saito Takashi、Saido Takaomi C.、Tomita Taisuke、Sohma Youhei、Kanai Motomu
    • Journal Title

      Chem

      Volume: 4 Issue: 4 Pages: 807-820

    • DOI

      10.1016/j.chempr.2018.02.008

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 4‐Fluorophenyl 3‐nitro‐2‐pyridinesulfenate as a practical protecting agent for amino acids2018

    • Author(s)
      Yan Cui, Cedric Rentier, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi
    • Journal Title

      Journal of Peptide Science

      Volume: 24 Issue: 3

    • DOI

      10.1002/psc.3070

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Efficient Method for the Conjugation of Hydrophilic and Hydrophobic Components by Solid-Phase-Assisted Disulfide Ligation2018

    • Author(s)
      Muguruma Kyohei、Shirasaka Takuya、Akiyama Daichi、Fukumoto Kentarou、Taguchi Akihiro、Takayama Kentaro、Taniguchi Atsuhiko、Hayashi Yoshio
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 8 Pages: 2170-2173

    • DOI

      10.1002/anie.201712324

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification2017

    • Author(s)
      Takayama Kentaro、Rentier Cedric、Asari Tomo、Nakamura Akari、Saga Yusuke、Shimada Takahiro、Nirasawa Kei、Sasaki Eri、Muguruma Kyohei、Taguchi Akihiro、Taniguchi Atsuhiko、Negishi Yoichi、Hayashi Yoshio
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 8 Issue: 7 Pages: 751-756

    • DOI

      10.1021/acsmedchemlett.7b00168

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] ペプチド-光酸素化触媒コンジュゲートを用いたマイオスタチンの活性阻害2019

    • Author(s)
      岡本英之, 谷口敦彦, 宇佐美翔哉, 田口晃弘, 高山健太郎, 林良雄
    • Organizer
      日本薬学会第 139 年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Peptide-Catalyst Conjugate for Photooxygenation of Myostatin2018

    • Author(s)
      H. Okamoto, A. Taniguchi, S. Usami, A. Taniguchi, K. Takayama, Y. Hayashi
    • Organizer
      10th International Peptide Symposium / 55th Japanese Peptide Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural requirements of mouse myostatin prodomain-derived small peptide for effective myostatin inhibition2018

    • Author(s)
      K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. T. Shimada, Taguchi, A. Taniguchi, Y. Negishi, Y. Hayashi
    • Organizer
      8th Peptide Engineering Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural requirements for the effective myostatin inhibition of myostatin prodomain-derived peptide derivatives2018

    • Author(s)
      K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. Taguchi, A. Taniguchi, Y. Hayashi
    • Organizer
      256th American Chemical Society National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structural derivatization for the effective myostatin inhibition of myostatin prodomain-derived peptide derivatives2018

    • Author(s)
      K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. Taguchi, A. Taniguchi, Y. Negishi, Y. Hayashi
    • Organizer
      11th Japanese-French Workshop “New insights in personalized medicine for neuromuscular diseases: From Basic to Applied Myology”
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小型化マイオスタチン阻害ペプチドの発見と高活性誘導体の創製2018

    • Author(s)
      六本木佳美、高山健太郎、齊藤まりこ、中村明里、嶋田嵩大、田口晃弘、谷口敦彦、根岸洋一、林良雄
    • Organizer
      創薬懇話会2017 in 志賀島
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイオスタチン阻害ペプチドの小型化と構造活性相関研究2018

    • Author(s)
      高山健太郎、淺利知、齋藤まりこ、六本木佳美、中村明里、佐賀裕介、嶋田嵩大、池山弘晃、田口晃弘、谷口敦彦、根岸洋一、林良雄
    • Organizer
      日本筋学会第4回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイオスタチン阻害を目指したペプチド-光酸素化触媒コンジュゲートの開発2018

    • Author(s)
      岡本英之,谷口敦彦,宇佐美翔哉,田口晃弘,高山健太郎,林良雄
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 網羅的構造活性相関研究によるマウス由来マイオスタチン阻害ペプチドの高活性化2018

    • Author(s)
      高山健太郎,淺利知,齋藤まりこ,六本木佳美,中村明里,嶋田嵩大,池山弘晃,田口晃弘,谷口敦彦,根岸洋一,林良雄
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小型化マイオスタチン阻害ペプチドの発見と高活性化2018

    • Author(s)
      齊藤 まりこ、高山 健太郎、C. Rentier、中村 明里、嶋田 嵩大、六本木 佳美、田口 晃弘、谷口 敦彦、根岸 洋一、林 良雄
    • Organizer
      日本薬学会第 138 年会
    • Related Report
      2017 Research-status Report
  • [Presentation] ジスルフィド先導型環状ペプチド合成法による生理活性ペプチドの効率的合成2018

    • Author(s)
      飯田 啓斗,田口 晃弘,崔 岩,福元 早穂子,小林 清孝,倉石 彩恵香,高山 健太郎,谷口 敦彦,林 良雄
    • Organizer
      日本薬学会第 138 年会
    • Related Report
      2017 Research-status Report
  • [Presentation] マイオスタチン阻害ペプチドの活性強化を目指した網羅的構造活性相関研究2017

    • Author(s)
      高山 健太郎、池山 弘晃、C. Rentier、中村 明里、佐賀 裕介、嶋田 嵩大、齋藤 まりこ、田口 晃弘、谷口 敦彦、根岸 洋一、林 良雄
    • Organizer
      第61回日本薬学会関東支部大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 固相ジスルフィド架橋試薬を用いたペプチド-薬物架橋体の合成2017

    • Author(s)
      六車 共平、白坂 拓也、秋山 大地、田口 晃弘、高山 健太郎、谷口 敦彦、林 良雄
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 環状ジスルフィドペプチドの効率的合成を指向した新規ジスルフィド架橋試薬の創製2017

    • Author(s)
      小林 清孝、田口 晃弘、小谷 明、六車 共平、小林 美咲、崔 岩、福元 謙太郎、高山 健太郎、谷口 敦彦、袴田 秀樹、林 良雄
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] マイオスタチン阻害ペプチドの活性強化を目指した構造活性相関研究2017

    • Author(s)
      高山 健太郎、C. Rentier、淺利 知、中村 明里、佐賀 裕介、嶋田 嵩大、齋藤 まりこ、六本木 佳美、田口 晃弘、谷口 敦彦、根岸 洋一、林 良雄
    • Organizer
      日本筋学会第3回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] マイオスタチン阻害ペプチドの活性強化を指向した構造活性相関研究2017

    • Author(s)
      六本木 佳美、高山 健太郎、C. Rentier、中村 明里、佐賀 裕介、嶋田 嵩大、齋藤 まりこ、田口 晃弘、谷口 敦彦、根岸 洋一、林 良雄
    • Organizer
      日本ケミカルバイオロジー学会第12回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of a disulfide bond-forming agent toward efficient multi-disulfide peptide synthesis2017

    • Author(s)
      K. Kobayashi, A. Taguchi, A. Kotani, K. Muguruma, M. Kobayashi, Y. Cui, K. Fukumoto, K. Takayama, H. Hakamata, A. Taniguchi, Y. Hayashi
    • Organizer
      3rd Annual Peptides and Proteins Symposium Singapore (P2S2-2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a new method on Npys-based disulfide bond formation for the preparation of bioactive cyclic disulfide peptides2017

    • Author(s)
      A. Taguchi, K. Kobayashi, A. Kotani, K. Muguruma, M. Kobayashi, K. Fukumoto, K. Takayama, A. Taniguchi, H. Hakamata, Y. Hayashi
    • Organizer
      12th Annual Peptide Therapeutics Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] Curcumin-boron complex and pharmaceutical containing same2017

    • Inventor(s)
      Kanai, Soma, Ni, Taniguchi
    • Industrial Property Rights Holder
      Kanai, Soma, Ni, Taniguchi
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Research-status Report
    • Overseas

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Published: 2017-04-28   Modified: 2020-03-30  

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