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Search for neurophysiological biomarkers of language function using magnetoencephalography

Research Project

Project/Area Number 17K13271
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionOsaka University

Principal Investigator

Araki Toshihiko  大阪大学, 医学部附属病院, 技術職員 (20755277)

Research Collaborator HIRATA masayuki  
WATANABE yoshiyuki  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords言語機能 / 脳磁図 / 脳律動 / 加齢 / 記憶力 / 脳活動 / バイオマーカー
Outline of Final Research Achievements

In this study, in order to detect brain activity that reflects language ability, we compared brain activity when thinking about the language of the elderly group whose language ability is assumed to decrease with aging and the young group. As a result, in the elderly group, the power of brain activity was higher than that in the young group. In particular, the power of activity in the left hemisphere, which is an area responsible for language, was high. Furthermore, when we examined the relationship between the verbal IQ/memory and the power of brain activity, IQ was not related between brain activity in both the elderly group and the younger group. With regard to verbal memory, it was clarified that the higher the brain activity in the young group, the lower the verbal memory score.

Academic Significance and Societal Importance of the Research Achievements

従来の言語記憶力テストは検査所要時間が1時間程度かかり、実際に言語能力の低下した患者にとって負担が大きく、検査施行が困難であることも少なくない。それに対し、本研究で採用した言語課題を脳磁図で実施する場合、課題自体が簡単で検査時間も10分程度であり、患者にとって心身ともに負担が少ない。よって、本研究成果は、患者にとって簡便で負担の少ない言語記憶検査法の開発に寄与するものと考えられる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Frequency-specific genetic influence on inferior parietal lobule activation commonly observed during action observation and execution2017

    • Author(s)
      Araki Toshihiko、Onishi Mai、Yanagisawa Takufumi、Hirata Masayuki、Watanabe Yoshiyuki、Ogata Soshiro、Hayakawa Kazuo、Honda Chika、Watanabe Mikio、Iwatani Yoshinori、Yorifuji Shiro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 17660-17660

    • DOI

      10.1038/s41598-017-17662-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-invasive detection of language-related prefrontal high gamma band activity with beamforming MEG2017

    • Author(s)
      Hashimoto Hiroaki、Hasegawa Yuka、Araki Toshihiko、Sugata Hisato、Yanagisawa Takufumi、Yorifuji Shiro、Hirata Masayuki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14262-14262

    • DOI

      10.1038/s41598-017-14452-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequency-dependent oscillatory neural profiles during imitation2017

    • Author(s)
      Sugata H, Hirata M, Tamura Y, Onishi H, Goto T, Araki T, Yorifuji S
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 45806-45806

    • DOI

      10.1038/srep45806

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 脳活動から言語能力は推定できるか2019

    • Author(s)
      荒木 俊彦
    • Organizer
      第68回日本医学検査学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高齢者における言語関連脳磁界の時空間解析2018

    • Author(s)
      荒木 俊彦, 渡邉 嘉之, 平田 雅之
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳磁図を用いた高齢者における言語関連脳活動の時空間変化2018

    • Author(s)
      荒木 俊彦
    • Organizer
      第67回日本医学検査学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Spatiotemporal profiles of neuromagnetic oscillatory changes related to the movement imitation2017

    • Author(s)
      Sugata Hisato, Hirata Masayuki, Tamura Yuichi, Araki Toshihiko, Onishi Hisao, Yorifuji Shiro
    • Organizer
      Neuroscience 2017, Washington D.C
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Non-invasive detection of language-related prefrontal high gamma band activity with beamforming MEG2017

    • Author(s)
      Hashimoto Hiroaki, Hasegawa Yuka, Araki Toshihiko, Yanagisawa Takufumi, Yorifuji Shiro, Hirata Masayuki
    • Organizer
      Biomagnetic Sendai 2017, Sendai
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2020-03-30  

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