| Project/Area Number |
17K14928
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Honjo Ken 筑波大学, 生命環境系, 特任助教 (50731866)
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| Research Collaborator |
KONDO Shu
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 侵害受容 / 痛覚 / 神経ぺプチド / 神経内分泌 / ショウジョウバエ |
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| Outline of Final Research Achievements |
Neuropeptides have been extensively studied as key components in regulating pain. However, despite its long history of research, the in vivo mechanisms of pain regulation mediated by neuropeptides remain largely unclear. This study aimed to reveal the in vivo mechanisms of nociceptive regulation mediated by RF-amide type neuropeptides utilizing Drosophila model at a cellular resolution.
This study focused on three RF-amide type neuropeptides in Drosophila, and gained novel insights on their target neurons and receptor molecules in regulating nociceptive responses.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で注目したRFアミド型神経ぺプチドは、哺乳類では30年以上前から痛覚の調節に関わるものと考えられてきたが、その機能メカニズムについては理解が進んでこなかった。ショウジョウバエを用いた本研究で得られた、その侵害受容調節メカニズムの細胞レベルでの知見は、哺乳類において進化的に保存された神経ぺプチドがどのように痛覚調節を行っているかを理解していく上で、有用な手掛かりを提供すると考えられる。
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