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The brain mechanisms regulated righty and lefty in a scale-eating fish

Research Project

Project/Area Number 17K14934
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionUniversity of Toyama

Principal Investigator

Takeuchi Yuichi  富山大学, 学術研究部医学系, 助教 (40508884)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords左右性 / 脳の左右差 / 学習 / 捕食行動 / 遺伝子発現 / 利き / RNA-seq / 脳の機能分化 / 表現型多型 / シクリッド / 神経科学 / 行動学 / 生態学
Outline of Final Research Achievements

We investigated the neural elements, developmental processes, and genetic basis for laterality in the scale-eating fish, Perissodus microlepis, of Lake Tanganyika. Aiming at whether there is a laterality in scale-eating behavior (i.e., attack side preference) for the first time after birth, a predation experiment was carried out using naive juveniles raised only on artificial feed. The attack side preference of the first day of scale-eating was relatively weak but the strengthened by repeated predation. That is, this behavioral laterality is acquired based on the scale-eating experience. In addition, the brain genes related to the difference between lefty and righty fish and the two hemispheres were analyzed by RNA-seq. We identified a gene that is characteristic of the right or left hemisphere. Among them, genes involved in left-right axis determination in the early embryo were included, suggesting that they are involved in the maintenance of left-right difference in the adult brain.

Academic Significance and Societal Importance of the Research Achievements

利き手のように体の片方を主に使う行動様式は脳内でどのように制御されるのか?左右の脳は高度に機能分化しており、その機構解明は脳科学上の重要な課題の一つである。私はタンガニイカ湖の鱗食魚を用いて、捕食時にみられる襲撃方向の利きは経験依存的な学習によって確立されるが、運動能力の左右差は生まれつき決まっていることを突き止めた。ヒトの利き手を代表として、様々な動物に広く認められるが、実はその獲得機構は、ほとんど明らかになっていなかった。鱗食魚の利きは非常に明瞭で、それを制御する入力から出力までの神経回路が想定できる。今後は、いまだ謎に包まれた「利きの脳内制御機構」の全容が解明できると考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (20 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (11 results) (of which Invited: 1 results) Book (3 results) Remarks (1 results)

  • [Int'l Joint Research] University of Malawi(マラウイ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Lateralized expression of left-right axis formation genes is shared by adult brains of lefty and righty scale-eating cichlids2018

    • Author(s)
      Takeuchi Yuichi、Ishikawa Asano、Oda Yoichi、Kitano Jun
    • Journal Title

      Comparative Biochemistry and Physiology Part D: Genomics and Proteomics

      Volume: 28 Pages: 99-106

    • DOI

      10.1016/j.cbd.2018.07.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Specialized movement and laterality of fin-biting behaviour in Genyochoromis mento in Lake Malawi2018

    • Author(s)
      Takeuchi Yuichi、Hata Hiroki、Maruyama Atsushi、Yamada Takuto、Nishikawa Takuma、Fukui Makiko、Zatha Richard、Rusuwa Bosco、Oda Yoichi
    • Journal Title

      The Journal of Experimental Biology

      Volume: 222 Pages: 1-9

    • DOI

      10.1242/jeb.191676

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Laterality is Universal Among Fishes but Increasingly Cryptic Among Derived Groups2017

    • Author(s)
      Hori Michio、Nakajima Mifuyu、Hata Hiroki、Yasugi Masaki、Takahashi Satoshi、Nakae Masanori、Yamaoka Kosaku、Kohda Masanori、Kitamura Jyun-ichi、Maehata Masayoshi、Tanaka Hirokazu、Okada Norihiro、Takeuchi Yuichi
    • Journal Title

      Zoological Science

      Volume: 34 Issue: 4 Pages: 267-274

    • DOI

      10.2108/zs160196

    • NAID

      120006402033

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lateralized scale-eating behaviour of cichlid is acquired by learning to use the naturally stronger side2017

    • Author(s)
      Takeuchi Yuichi、Oda Yoichi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 8384-8384

    • DOI

      10.1038/s41598-017-09342-7

    • NAID

      120006399283

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 鱗食性シクリッドで見られる利き獲得の学習効果には臨界期がある2020

    • Author(s)
      竹内勇一、小田洋一
    • Organizer
      第67回日本生態学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マラウィ湖産ヒレ食性シクリッド科魚類の捕食行動の特殊性と左右性2019

    • Author(s)
      竹内勇一、畑啓生、丸山敦、山田拓人、西川巧馬、Richard Zatha、Bosco Rusuwa、小田洋一
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鱗食魚における左右性の可塑性2019

    • Author(s)
      竹内勇一、小田洋一
    • Organizer
      第90回日本動物学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鱗食魚における右脳/左脳に特有な発現を示す遺伝子群2019

    • Author(s)
      竹内勇一、石川麻乃、小田洋一、北野潤
    • Organizer
      第66回日本生態学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 鱗食魚の右利き・左利きで共通した非対称な脳内遺伝子発現2018

    • Author(s)
      竹内勇一、北野潤、石川麻乃、小田洋一
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 鱗食性シクリッドにおける襲撃方向の選択と左右性2018

    • Author(s)
      竹内勇一
    • Organizer
      日本動物学会第89回札幌大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] マラウィ湖の鰭食い魚における捕食行動の「利き」2018

    • Author(s)
      山田拓人、畑啓生、丸山敦、西川巧馬、Richard Zatha、Bosco Rusuwa、福井眞生子、小田洋一、竹内勇一
    • Organizer
      日本動物行動学会第37回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 魚食・鱗食・ヒレ食のシクリッド3種における口部形態の左右差の比較2018

    • Author(s)
      西川巧馬、丸山敦、畑啓生、Richard Zatha、Bosco Rusuwa、小田洋一、竹内勇一
    • Organizer
      第65回日本生態学会
    • Related Report
      2017 Research-status Report
  • [Presentation] マラウィ湖産ヒレ食シクリッドの捕食行動の左右性2018

    • Author(s)
      竹内勇一、畑啓生、丸山敦、山田拓人、西川巧馬、Richard Zatha、Bosco Rusuwa、小田洋一
    • Organizer
      第65回日本生態学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 鱗食性シクリッドにおける鱗食経験により獲得される捕食行動の左右性2017

    • Author(s)
      竹内勇一、小田洋一
    • Organizer
      第40回日本神経科学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] マラウィ湖に生息するヒレ食シクリッドの左右性2017

    • Author(s)
      竹内勇一、畑啓生、丸山敦、山田拓人、西川巧馬、Richard Zatha、Bosco Rusuwa、小田洋一
    • Organizer
      第88回日本動物学会
    • Related Report
      2017 Research-status Report
  • [Book] スポーツが得意な子に育つたのしいお話3652019

    • Author(s)
      一般社団法人 日本体育学会
    • Total Pages
      416
    • Publisher
      誠文堂新光社
    • ISBN
      9784416618707
    • Related Report
      2018 Research-status Report
  • [Book] 魚類学の百科事典2018

    • Author(s)
      一般社団法人日本魚類学会
    • Total Pages
      756
    • Publisher
      丸善出版
    • ISBN
      9784621303177
    • Related Report
      2018 Research-status Report
  • [Book] 調べる学習子ども年鑑20182018

    • Author(s)
      朝日小学生新聞
    • Total Pages
      224
    • Publisher
      岩崎書店
    • ISBN
      9784265099542
    • Related Report
      2017 Research-status Report
  • [Remarks] 鰭(ヒレ)を食べるアフリカの魚にも利きがあることを発見

    • URL

      https://www.u-toyama.ac.jp/education/news/2018/1219a.html

    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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