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Identification of novel biomarkers and therapeutic targets for refractory malignant solid tumors by comprehensive omics analyses

Research Project

Project/Area Number 17K15038
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Genome biology
Research InstitutionGunma University

Principal Investigator

Kawabata Reika  群馬大学, 未来先端研究機構, 講師 (90721928)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords肺がん / トリプルネガティブ乳がん / 予後予測マーカー / 治療標的 / RNA-seq / 新規治療標的 / 免疫組織染色 / バイオマーカー / 小細胞肺がん / 肺扁平上皮がん / 化学療法耐性機構 / 癌 / ゲノム / 遺伝子
Outline of Final Research Achievements

Lung squamous cell carcinoma (LSCC), small cell lung carcinoma (SCLC) and triple-negative breast cancer (TNBC) remain challenging diseases to treat, and further improvements in prognosis are dependent upon the identification of LSCC/SCLC/TNBC-specific therapeutic biomarkers and/or targets. To identify novel prognostic markers/therapeutic targets for LSCC/SCLC/TNBC, omics analyses were conducted using surgical/pathological specimens and clinical data obtained in Gunma University Hospital, thousands patient’s data from public database, cancer cell lines and mice. Expression of STMN1 or STXBP4/ΔNp63 in LSCC, STMN1 or TRIT1 in SCLC and CASP14 or CPA4 in TNBC were identified as potential prognostic markers/therapeutic targets and could afford keys to the development of precision medicine for LSCC/SCLC/TNBC patients.

Academic Significance and Societal Importance of the Research Achievements

近年の網羅的なゲノム・遺伝子解析は、多くのヒトがんにおける多様なゲノム異常の存在を明らかにしつつある。肺がんは本邦でがん死因第1位の難治がんであり、分子標的治療が行われているが、LSCCやSCLCでは標的となる遺伝子異常がほとんど同定されていない。TNBCは乳がん全体の15-20%を占め、予後が著しく悪い症例が認められる。TNBCはホルモン受容体やHER2といった分子標的がすべて陰性であり、有用な治療標的の同定が求められている。本研究で同定された予後予測マーカーや候補治療標的分子により、これらの患者のがん個別化医療の発展に繋がると期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2021 2020 2019 2017

All Journal Article (10 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 5 results)

  • [Journal Article] Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer2021

    • Author(s)
      Coll-SanMartin Laia、Davalos Veronica、Pi?eyro David、Rossell?-Tortella Margalida、Bueno-Costa Alberto、Setien Fernando、Villanueva Alberto、Granada Isabel、Ruiz-Xiviller Neus、Kotter Annika、Helm Mark、Yokota Jun、Kawabata-Iwakawa Reika、Kohno Takashi、Esteller Manel
    • Journal Title

      Cancers

      Volume: 13 Issue: 8 Pages: 1869-1869

    • DOI

      10.3390/cancers13081869

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine2020

    • Author(s)
      Bilguun Erkhem-Ochir、Kaira Kyoichi、Kawabata-Iwakawa Reika、Rokudai Susumu、Shimizu Kimihiro、Yokobori Takehiko、Oyama Tetsunari、Shirabe Ken、Nishiyama Masahiko
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 935-935

    • DOI

      10.1186/s12885-020-07448-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stathmin-1 Is a Useful Diagnostic Marker for High-Grade Lung Neuroendocrine Tumors2019

    • Author(s)
      Shimizu Kimihiro、Goto Yusuke、Kawabata-Iwakawa Reika、Ohtaki Yoichi、Nakazawa Seshiru、Yokobori Takehiko、Obayashi Kai、Kawatani Natsuko、Yajima Toshiki、Kaira Kyoichi、Mogi Akira、Hirato Junko、Nishiyama Masahiko、Shirabe Ken
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 108 Issue: 1 Pages: 235-243

    • DOI

      10.1016/j.athoracsur.2019.02.040

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carboxypeptidase A4 accumulation is associated with an aggressive phenotype and poor prognosis in triple-negative breast cancer2019

    • Author(s)
      Handa Tadashi、Katayama Ayaka、Yokobori Takehiko、Yamane Arito、Fujii Takaaki、Obayashi Sayaka、Kurozumi Sasagu、Kawabata-Iwakawa Reika、Gombodorj Navchaa、Nishiyama Masahiko、Asao Takayuki、Shirabe Ken、Kuwano Hiroyuki、Oyama Tetsunari
    • Journal Title

      International Journal of Oncology

      Volume: Mar;54(3) Pages: 833-844

    • DOI

      10.3892/ijo.2019.4675

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Significantly mutated genes and regulatory pathways in SCLC?a meta-analysis2017

    • Author(s)
      Sundaresan Varsha、Lin Victor T.、Liang Faming、Kaye Frederic J.、Kawabata-Iwakawa Reika、Shiraishi Kouya、Kohno Takashi、Yokota Jun、Zhou Lei
    • Journal Title

      Cancer Genetics

      Volume: 216-217 Pages: 20-28

    • DOI

      10.1016/j.cancergen.2017.05.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma2017

    • Author(s)
      Otaka Yukihiro、Rokudai Susumu、Kaira Kyoichi、Fujieda Michiru、Horikoshi Ikuko、Iwakawa-Kawabata Reika、Yoshiyama Shinji、Yokobori Takehiko、Ohtaki Yoichi、Shimizu Kimihiro、Oyama Tetsunari、Tamura Jun'ichi、Prives Carol、Nishiyama Masahiko
    • Journal Title

      Clinical Cancer Research

      Volume: 23 Issue: 13 Pages: 3442-3452

    • DOI

      10.1158/1078-0432.ccr-16-1815

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma2017

    • Author(s)
      Bao Pinjie、Yokobori Takehiko、Altan Bolag、Iijima Misaki、Azuma Youko、Onozato Ryoichi、Yajima Toshiki、Watanabe Akira、Mogi Akira、Shimizu Kimihiro、Nagashima Toshiteru、Ohtaki Yoichi、Obayashi Kai、Nakazawa Seshiru、Bai Tuya、Kawabata-Iwakawa Reika、Asao Takayuki、Kaira Kyoichi、Nishiyama Masahiko、Kuwano Hiroyuki
    • Journal Title

      Annals of Surgical Oncology

      Volume: 24 Issue: 13 Pages: 4017-4024

    • DOI

      10.1245/s10434-017-6083-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients2017

    • Author(s)
      Handa Tadashi、Katayama Ayaka、Yokobori Takehiko、Yamane Arito、Horiguchi Jun、Kawabata-Iwakawa Reika、Rokudai Susumu、Bao Pinjie、Gombodorj Navchaa、Altan Bolag、Kaira Kyoichi、Asao Takayuki、Kuwano Hiroyuki、Nishiyama Masahiko、Oyama Tetsunari
    • Journal Title

      Journal of Surgical Oncology

      Volume: 116 Issue: 6 Pages: 706-715

    • DOI

      10.1002/jso.24705

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Myeloid sarcoma arising in malignant phyllodes tumour: clonal relationships revealed by comparative genome-wide analyses2017

    • Author(s)
      Arai Hideo、Nobusawa Sumihito、Kawabata-Iwakawa Reika、Rokudai Susumu、Higuchi Toru、Yamazaki Tatsuya、Horiguchi Jun、Sano Takaaki、Kojima Masaru、Nishiyama Masahiko、Yokoo Hideaki、Hirato Junko、Oyama Tetsunari
    • Journal Title

      British Journal of Haematology

      Volume: 181 Issue: 2 Pages: 255-259

    • DOI

      10.1111/bjh.14539

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Next-Generation Sequencing and Bioinformatics2017

    • Author(s)
      Kawabata-Iwakawa Reika、Bono Hidemasa、Nishiyama Masahiko
    • Journal Title

      Molecular Targeted Therapy of Lung Cancer

      Volume: - Pages: 97-115

    • DOI

      10.1007/978-981-10-2002-5_6

    • ISBN
      9789811020001, 9789811020025
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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