Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
ADP-ribosylation is an important post-translational modification of protein. However, recent researches show that DNA is also ADP-ribosylated. ScARP from Streptomyces coelicolor ADP-ribosylates guanine. In this study, I revealed how ScARP recognizes GDP using X-ray crystallography. The ternary complex structure of ScARP, GDP, and NAD show that the recognition mechanisms of protein and DNA are common.
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