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Role of intracellular magnesium in cell-cycle progression

Research Project

Project/Area Number 17K15108
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biophysics
Research InstitutionTokyo University of Science, Yamaguchi (2018-2019)
Keio University (2017)

Principal Investigator

Yamanaka Ryu  山陽小野田市立山口東京理科大学, 薬学部, 助教 (90795436)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsマグネシウムイオン / 蛍光イメージング / 細胞周期 / 生物物理 / マグネシウム / ダイナミクス / 細胞内情報伝達 / エネルギー代謝 / シグナル伝達 / 細胞内代謝 / 生体生命情報学 / 生理学 / 細胞・組織
Outline of Final Research Achievements

In this study, we revealed that the concentration of the intracellular magnesium ion is dynamically changed during the progression of cell-cycle, and the changes actively regulate cell-cycle progression in each stages of cell-cycle. In addition, we revealed that intracellular magnesium regulates several intracellular signalling related to cell proliferation. We reported two paper and are preparing a paper about these results for the submission.

Academic Significance and Societal Importance of the Research Achievements

本研究では、細胞周期の進行と細胞内マグネシウムイオン動態の関係に着目した研究を行なった。細胞周期の進行は細胞増殖速度を決定するが、マグネシウムイオンが制御している可能性を示唆した。この結果は、マグネシウムイオンは、がん等、細胞増殖がかかわる疾患の治療や予防のターゲット分子である可能性を示唆している。つまり今回、発見した細胞内Mgイオン動態とその役割は細胞生物学における基礎的な知見になるだけでなく、がんなど細胞分裂が関わる疾患の治療法開発のための重要な知見となる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018 2017 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Magnesium Is a Key Player in Neuronal Maturation and Neuropathology2019

    • Author(s)
      Yamanaka Ryu, Shindo Yutaka, Oka Kotaro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 14 Pages: 3439-3439

    • DOI

      10.3390/ijms20143439

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GABA-Induced Intracellular Mg2+ Mobilization Integrates and Coordinates Cellular Information Processing for the Maturation of Neural Networks2018

    • Author(s)
      Ryu Yamanaka, Yutaka Shindo, Kohji Hotta, Koji Suzuki, Kotaro Oka
    • Journal Title

      Current Biology

      Volume: 28 Issue: 24 Pages: 3984-3991

    • DOI

      10.1016/j.cub.2018.10.044

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Quantitative analysis of cell cycle progression within heterogeneous cell population using information theory2019

    • Author(s)
      Ryu Yamanaka, Kotaro Oka
    • Organizer
      The 6th International Symposium on Bioimaging
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経ネットワークの成熟におけるMg2+シグナルの定量的解析2018

    • Author(s)
      山中龍、新藤豊、堀田耕司、鈴木孝治、岡浩太郎
    • Organizer
      定量生物学の会
    • Related Report
      2018 Research-status Report
  • [Presentation] GABA-induced intracellular Mg2+mobilization integrates and coordinates cellular information processing for the maturation of neural networks2018

    • Author(s)
      RyuYamanaka, Yutaka Shindo, Kohji Hotta, Koji Suzuki, Kotaro Oka
    • Organizer
      2019, Winter Q-bio
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] GABA-induced Mg2+ signaling facilitates neuronal differentiation in developing neurons2017

    • Author(s)
      Ryu Yamanaka
    • Organizer
      日本神経科学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inhibition of Na+/Mg2+ exchanger protects neurons from excitotoxicity2017

    • Author(s)
      Yutaka Shindo, Ryu Yamanaka, Koji Suzuki, Kohji Hotta, Kotaro Oka
    • Organizer
      日本神経科学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Characterization of Neurons and astrocytes derived from human dental pulp stem cells2017

    • Author(s)
      Yuki Arimura, Toko Kikuchi, Ryu Yamanaka, Yutaka Shindo, Koji Hotta, Mai Mochizuki, Taka Nakahara, Kotaro Oka
    • Organizer
      日本神経科学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Estimation of energy metabolism by fluorescent imagings.2017

    • Author(s)
      Mitsuru Iizumi, Rika Suzuki, Ryu Yamanaka, Yutaka Shindo, Kohji Hotta, Kotaro Oka
    • Organizer
      日本神経科学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Magnesium signaling activated by GABA facilitates neuronal differentiation in developing neurons2017

    • Author(s)
      Ryu Yamanaka, Yutaka Shindo, Kohji Hotta, Koji Suzuki, Kotaro Oka
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characteristics of neuronal differentiated cells derived from human dental pulp stem cells (hDPSCs)2017

    • Author(s)
      Yuki Arimura, Toko Kikuchi, Ryu Yamanaka, Yutaka Shindo, Koji Hotta, Mai Mochizuki, Taka Nakahara, Kotaro Oka
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Estimation of metabolic energy balance in neurons by using fluorescent imagings2017

    • Author(s)
      Mitsuru Iizumi, Rika Suzuki, Ryu Yamanaka, Yutaka Shindo, Kohji Hotta, Kotaro Oka
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 数でとらえる細胞生物学2020

    • Author(s)
      Ron Milo、Rob Phillips、舟橋 啓(監訳)、板橋 正寛、大岡 麻耶、小林 佑也、斎藤 昴哉、徳岡 雄大、中村 隆之、中村 善次、西本 勝利、広井 賀子、本室 美貴子、山崎 孔敬、山田 貴大、山中 龍(翻訳:五十音順)
    • Total Pages
      320
    • Publisher
      羊土社
    • ISBN
      9784758121064
    • Related Report
      2019 Annual Research Report
  • [Remarks] javascript:onSave()

    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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