The regulation of STING pathway
Project/Area Number |
17K15445
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | Tohoku University (2018-2019) The University of Tokyo (2017) |
Principal Investigator |
Kojiro Mukai 東北大学, 生命科学研究科, 助教 (90767633)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 自然免疫 / リソソーム / 細胞内膜輸送 |
Outline of Final Research Achievements |
Stimulator of interferon genes (STING) is essential for the type I interferon response against DNA pathogens. In this project, we examined the regulation of STING pathway, and found that the translocation of STING to lysosome was required for termination of the type I interferon signaling.
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Academic Significance and Societal Importance of the Research Achievements |
本研究の成果として、STINGがリソソームにおいて蛋白質分解を受けることで、STING経路の活性化が収束することが分かり、その分子機構の一端が明らかとなった。この研究成果は、細胞生物学基礎研究として重要であると同時に、免疫チェックポイント阻害剤の適用をより広汎にするための新規創薬標的分子の同定につながる可能性を秘めている。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells2017
Author(s)
Matsudaira, T., K. Mukai, T. Noguchi, J. Hasegawa, T. Hatta, S. Iemura, T. Natsume, N. Miyamura, H. Nishina, J. Nakayama, K. Semba, T. Tomita, S. Murata, H. Arai, and T. Taguchi
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Journal Title
Nature Communications
Volume: 8(1)
Issue: 1
Pages: 651-651
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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