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The role of FABP7 in the regulation of lipid raft function

Research Project

Project/Area Number 17K15539
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionTohoku University

Principal Investigator

Kagawa Yoshiteru  東北大学, 医学系研究科, 助教 (30728887)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脂肪酸結合蛋白質 / FABP7 / アストロサイト / 脂質ラフト / エピゲノム / ヒストンアセチル化 / アセチルCoA / ATP-citrate synthase / グリオーマ / caveolin-1 / Acetyl CoA / 精神疾患 / 神経科学 / 細胞・組織 / 脂質 / 遺伝子 / 蛋白質
Outline of Final Research Achievements

Fatty acids intake is very important for brain development as lack of fatty acids intake is associated with mental disorders. However, the involving molecular mechanism based on brain development is still unknown. In this study, we focused on the fatty acid binding protein FABP7, which is strongly expressed in brain astrocytes and regulates its intracellular lipid dynamics by trying to elucidate its functional role in the neuronal cells.
The main points that have become clear are: 1) FABP7 interacts with enzymes that are important for nuclear acetyl-CoA production by binding to fatty acids, and controlling their activity, 2) Epigenetic changes occur depending on the amount of acetyl CoA regulated by FABP7, 3) the expression of the lipid raft scaffold protein caveolin-1 is epigenetically regulated.

Academic Significance and Societal Importance of the Research Achievements

本研究により、細胞内脂質環境の変化が新たな蛋白質相互作用を生み出し、エピゲノム変化に影響を及ぼすことが示唆される。さらに詳細な解析を加えることで、FABP7が関与する精神疾患病態や癌バイオロジーの解明及びそれら疾患の治療創薬の開発に大きく貢献できると考える。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (21 results)

All 2019 2018 2017 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (15 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Role of FABP7 in tumor cell signaling2019

    • Author(s)
      Kagawa Yoshiteru、Umaru Banlanjo A.、Ariful Islam、Shil Subrata Kumar、Miyazaki Hirofumi、Yamamoto Yui、Ogata Masaki、Owada Yuji
    • Journal Title

      Advances in Biological Regulation

      Volume: 71 Pages: 206-218

    • DOI

      10.1016/j.jbior.2018.09.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FABP7 Protects Astrocytes Against ROS Toxicity via Lipid Droplet Formation2019

    • Author(s)
      Islam Ariful、Kagawa Yoshiteru、Miyazaki Hirofumi、Shil Subrata Kumar、Umaru Banlanjo A.、Yasumoto Yuki、Yamamoto Yui、Owada Yuji
    • Journal Title

      Molecular Neurobiology

      Volume: - Issue: 8 Pages: 5763-5779

    • DOI

      10.1007/s12035-019-1489-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis.2019

    • Author(s)
      Kamizato K, Sato S, Shil SK, Umaru BA, Kagawa Y, Yamamoto Y, Ogata M, Yasumoto Y, Okuyama Y, Ishii N, Owada Y, Miyazaki H.
    • Journal Title

      Neuroscience

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus2018

    • Author(s)
      Yasumoto Yuki、Miyazaki Hirofumi、Ogata Masaki、Kagawa Yoshiteru、Yamamoto Yui、Islam Ariful、Yamada Tetsuya、Katagiri Hideki、Owada Yuji
    • Journal Title

      Molecular Neurobiology

      Volume: - Issue: 12 Pages: 9016-9028

    • DOI

      10.1007/s12035-018-1033-9

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67 Promoter Region2018

    • Author(s)
      Yamamoto Yui、Kida Hiroyuki、Kagawa Yoshiteru、Yasumoto Yuki、Miyazaki Hirofumi、Islam Ariful、Ogata Masaki、Yanagawa Yuchio、Mitsushima Dai、Fukunaga Kohji、Owada Yuji
    • Journal Title

      The Journal of Neuroscience

      Volume: 38 Issue: 49 Pages: 10411-10423

    • DOI

      10.1523/jneurosci.1285-18.2018

    • NAID

      130007813353

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Role of FABP7 in astrocytes and its possibe association with psychiatric diseases.2019

    • Author(s)
      Yoshiteru Kagawa, Umaru Banlanjo, Yuji Owada
    • Organizer
      Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care(星稜オーディトリウム, 仙台)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂肪酸結合蛋白質FABP7とATP-citrate lysis(ACLY)の相互作用による核内Acetyl CoAの量的調節機構2019

    • Author(s)
      香川慶輝, Umaru Banlanjo Abdulaziz, 大和田祐二
    • Organizer
      第124回日本解剖学会総会全国学術集会(朱鷺メッセ,新潟)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脱髄疾患におけるアストロサイトの脂肪酸結合蛋白質FABP7の機能的役割の検討2019

    • Author(s)
      宮崎啓史, 神里賢勇, 佐藤匠、香川慶輝, 大和田祐二
    • Organizer
      第124回日本解剖学会総会全国学術集会(朱鷺メッセ,新潟)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Role of mitochondrial complex 1 and its subunit Ndufs4 in the regulation of glial and neuronal mitochondrial morphology and function2019

    • Author(s)
      Shil Subrata, Fumika Nanto, Hirofumi Miyazaki, Yoshiteru Kagawa, Yui Yamamoto, Yuji Owada
    • Organizer
      第124回日本解剖学会総会全国学術集会(朱鷺メッセ,新潟)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fatty acid binding protein 7 (FABP7) promotes glio,a cell proliferation through modulation of Wnt/β-catenin signaling2019

    • Author(s)
      Umaru Banlanjo, Yoshiteru Kagawa, Yuji Owada
    • Organizer
      第124回日本解剖学会総会全国学術集会(朱鷺メッセ,新潟)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質の細胞核局在がエピゲノム変化におよぼす影響2018

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第59回日本組織細胞化学会総会 シンポジウム「遺伝子発現のエピジェネティック制御とその破綻」(宮崎市民プラザ, 宮崎市)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞核内FABP7とATP citrate lyase (ACLY) の相互作用によるエピゲノム制御機構2018

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第41回日本分子生物学会(パシフィコ横浜, 横浜市)
    • Related Report
      2018 Annual Research Report
  • [Presentation] アストロサイトにおける脂肪酸結合蛋白質FABP7の機能解析2018

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] マクロファージの細胞内代謝変化による抗炎症性機能活性化とFABP7の関与の検討2018

    • Author(s)
      宮崎啓史, 宍戸愛, 安本有希, 香川慶輝, 大和田祐二
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Ndufs4欠損マウスにおける顎下腺・副腎の形態異常とステロイド合成障害2018

    • Author(s)
      小林祐太, 尾形雅君, 南都文香, 香川慶輝, 山本由似, 宮崎啓史, 伊藤将人, 香取幸夫, 阿部高明, 大和田祐二
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] FABP7 protects astrocyte against ROS toxicity under ROS stress2018

    • Author(s)
      Ariful Islam, Yoshiteru Kagawa, Hirofumi Miyazaki, Subrata Kumar Shil, Yuji Owada
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脂肪酸結合蛋白質FABP7によるヒストンアセチル化を介したcaveolin-1転写調節機構2017

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第11回エピジェネティクス研究会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] マクロファージの抗炎症性機能分化における細胞内代謝の変化とFABP7の関与2017

    • Author(s)
      宮崎啓史, 宍戸愛, 香川慶輝, 安本有希, 南都文香, 大和田祐二
    • Organizer
      日本解剖学会 第63回東北・北海道連合支部学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] FABP7は核内Acetyl-CoAレベル調節を介してエピジェネティックに遺伝子発現を制御する2017

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Research-status Report
  • [Presentation] FABP7 is involved in M2 polarization of macrophages via mitochondrial fatty-acid oxidation.2017

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Research-status Report
  • [Remarks] 東北大学大学院医学系研究科器官解剖学分野

    • URL

      http://www.organ-anatomy.med.tohoku.ac.jp/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2020-03-30  

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