| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Proteins and genomes of paramyxoviruses newly synthesized in the cytoplasm need to be transported to the plasma membrane where the budding occurs. In this study, we found Rab protein and actin-related proteins (RhoA and Profilin2) as host factors involved in intracellular transport of paramyxoviruses. These host factors promote intracellular transport of viral components by promoting transport of viral proteins to the plasma membrane or by activating transport-related signal through the binding with viral proteins, which leads to facilitate viral growth.
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