Analysis of a novel cell-cell contact-dependent signaling pathway in antiviral immune response

• Project/Area Number: 17K15725
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: National Institute of Advanced Industrial Science and Technology (2018); Osaka University (2017)
• Principal Investigator: Kumagai Yutaro 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (00528408)
• Research Collaborator: Trost Nina
• Project Period (FY): 2017-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 抗ウイルス免疫応答 / I型インターフェロン / 細胞間接触 / 免疫学

Outline of Final Research Achievements

We found a novel cell-cell contact dependent mechanism which controls production of type I interferon, a cytokine important for antiviral immune response. We investigated molecular mechanism of the cell-cell contact dependent signaling. Molecules inducing the cell-cell contact signaling, required downstream molecules, and gene expression program evoked by the signaling have been elucidated.

Academic Significance and Societal Importance of the Research Achievements

IFNの制御は抗ウイルス自然免疫応答のみならず、IFNのアジュバントとしての機能に関連した獲得免疫系の制御、自己免疫疾患への関与など非常に重要であり、今回の研究によって明らかになった新規の分子機構により今までできなかった治療、予防等へ繋がる可能性がある。

Research Products

• [Journal Article] Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation (2018)
  • Author(s): Vandenbon Alexis、Kumagai Yutaro、Lin Mengjie、Suzuki Yutaka、Nakai Kenta
  • Journal Title: Genome Biology Volume: 19 Issue: 1 Pages: 0-0
  • DOI: 10.1186/s13059-018-1524-z
  • NAID: 120006559396
  • Peer Reviewed / Open Access
• [Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception. (2018)
  • Author(s): Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
  • Journal Title: iScience Volume: 6 Pages: 306-318
  • DOI: 10.1016/j.isci.2018.08.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimation of diffusion constants from single molecular measurement without explicit tracking. (2018)
  • Author(s): Teraguchi Shunsuke、Kumagai Yutaro
  • Journal Title: BMC Systems Biology Volume: 12 Issue: S1 Pages: 25-39
  • DOI: 10.1186/s12918-018-0526-5
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. (2018)
  • Author(s): Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S.
  • Journal Title: Sci Transl Med. Volume: -- Issue: 429 Pages: 264-273
  • DOI: 10.1126/scitranslmed.aan0333
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intracellular Protein-Labeling Probes for Multicolor Single-Molecule Imaging of Immune Receptor?Adaptor Molecular Dynamics (2017)
  • Author(s): Sato Ryota、Kozuka Jun、Ueda Masahiro、Mishima Reiko、Kumagai Yutaro、Yoshimura Akimasa、Minoshima Masafumi、Mizukami Shin、Kikuchi Kazuya
  • Journal Title: Journal of the American Chemical Society Volume: 139 Issue: 48 Pages: 17397-17404
  • DOI: 10.1021/jacs.7b08262
  • Peer Reviewed
• [Journal Article] Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis (2017)
  • Author(s): Maruyama Kenta、Takayama Yasunori、Kondo Takeshi、Ishibashi Ken-ichi、Sahoo Bikash Ranjan、Kanemaru Hisashi、Kumagai Yutaro、Martino Mika?l M.、Tanaka Hiroki、Ohno Naohito、Iwakura Yoichiro、Takemura Naoki、Tominaga Makoto、Akira Shizuo
  • Journal Title: Cell Reports Volume: 19 Issue: 13 Pages: 2730-2742
  • DOI: 10.1016/j.celrep.2017.06.002
  • Peer Reviewed / Open Access / Int'l Joint Research