| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, to clarify whether any association between B7 family and Autoimmune thyroid disease exist associations, we genotyped polymorphisms and examined B7 family expressions in patients with Autoimmune thyroid disease and control subjects. We firstly reported that CD80 rs1599795 A/T and CD80 rs2222631 C/T were associated with HD severity and GD activity, respectively. CD86 rs2715267 A/C was also associated with the susceptibility of HD. In peripheral blood, CD80 on B cells and CD86 on monocytes were related to the severity and the susceptibility of Autoimmune thyroid disease, respectively.
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