Understanding the Mechanisms by Which Taurine Mitigates the Radiation-Induced Cellular Damages
| Project/Area Number |
17K15809
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | タウリン / タウリントランスポーター / 8-OhdG / 8-nitroguanine / TNF-α / 放射線損傷緩和 / 8-OHdG / 放射線 |
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| Outline of Final Research Achievements |
We tested the taurine administration on small intestinal injuries of mice after 4.5 Gy whole body X-irradiation. Taurine suppressed the decrease in the expression of taurine and taurine transporter in the small intestine after radiation exposure. Moreover, taurine suppressed radiation- induced oxidative damage in the small intestine after radiation exposure. These results suggest that taurine might compensate for the taurine losses via taurine transporter and, contribute to recovery from radiation-induced small intestine injury, possibly by suppressing an inflammation caused by cytokines and ROS.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒトへの放射線被ばく影響の緩和にタウリンを応用するために行った本研究の成果として、放射線暴露後のタウリン投与によりマウス小腸組織のタウリントランスポーター発現が増加し、組織中のDNA損傷を抑制することを明らかにした。このように放射線による細胞損傷をタウリンが調節する分子機構の一部を示したことで、がん治療や意図しない自然災害やテロリズムによって引き起こされる原子力発電所からの放射線暴露による一般人の放射線による細胞損傷軽減への応用が期待できる。
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Report
(4 results)
Research Products
(26 results)
