Arrhythmia and subclinical cerebrovascular disease

• Project/Area Number: 17K15827
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Hisamatsu Takashi 滋賀医科大学, 医学部, 客員准教授 (60710449)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 不整脈 / 時間医学 / 脳動脈硬化 / 一般集団 / 脳委縮 / 一般女性 / 脳萎縮 / 心房細動 / 上室性不整脈 / 認知機能

Outline of Final Research Achievements

The association between an increased supraventricular
ectopic beat (SVEB) and subclinical cerebrovascular disease remains
unclear.We conducted a population-based study of 462 participants who underwent 24-h Holter electrocardiography and brain magnetic resonance imaging. ESVEA was defined as the presence of >10 SVEBs/h. ESVEA was independently associated with higher burdens of white matter hyperintensity and intracranial artery stenosis, but not with silent brain infarct. This suggests that the effect of increased SVEBs on ischemic stroke may partly occur through development of subclinical cerebrovascular disease.

Academic Significance and Societal Importance of the Research Achievements

高齢化の更なる進展の中で、健康寿命・社会保障費の観点からも、脳卒中の更なる予防戦略の確立が喫緊の課題である。本研究は、有病率が高く脳卒中との関連が指摘されている不整脈（心房細動・期外収縮、等）の分布・関連要因を明らかにし、日概リズムの概念に基づき不整脈（心房細動・期外収縮、等）の関連要因を明らかにした。特に脳血管障害と関連する不整脈・日内変動異常を検討し、不整脈の時間医学モデルを構築を試みた。わが国における一般集団での知見が乏しい不整脈に着目した、脳卒中の一次予防および健康寿命の延伸に資する、国内でも希少な研究である。

Research Products

• [Journal Article] The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study (2020)
  • Author(s): Khan Md Maruf Haque、Fujiyoshi Akira、Shiino Akihiko、Hisamatsu Takashi、Torii Sayuki、Suzuki Sentaro、Kunimura Ayako、Segawa Hiroyoshi、Kadota Aya、Ohkubo Takayoshi、Nozaki Kazuhiko、Miura Katsuyuki、Ueshima Hirotsugu、for the SESSA Research Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 27 Issue: 9 Pages: 995-1009
  • DOI: 10.5551/jat.51284
  • NAID: 130007894637
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2020-09-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study (2020)
  • Author(s): Fujiyoshi Akira、Miura Katsuyuki、Ohkubo Takayoshi、Miyagawa Naoko、Saito Yoshino、Miyazawa Itsuko、Shiino Akihiko、Kadota Aya、Kadowaki Sayaka、Hisamatsu Takashi、Torii Sayuki、Takashima Naoyuki、Tooyama Ikuo、Ueshima Hirotsugu
  • Journal Title: Journal of Epidemiology Volume: 30 Issue: 6 Pages: 244-252
  • DOI: 10.2188/jea.JE20180258
  • NAID: 130007852129
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-06-05
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study (2020)
  • Author(s): Liu Ziyi、Zaid Maryam、Hisamatsu Takashi、Tanaka Sachiko、Fujiyoshi Akira、Miyagawa Naoko、Ito Takahiro、Kadota Aya、Tooyama Ikuo、Miura Katsuyuki、Ueshima Hirotsugu
  • Journal Title: Journal of Epidemiology Volume: 30 Issue: 3 Pages: 121-127
  • DOI: 10.2188/jea.JE20180193
  • NAID: 130007805895
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-03-05
  • Peer Reviewed
• [Journal Article] Anthropometric Obesity Indices were Stronger than CT-Based Indices in Associations with Carotid Intima-Media Thickness in Japanese Men (2019)
  • Author(s): Liu Yuyan、Fujiyoshi Akira、Arima Hisatomi、Kadota Aya、Kadowaki Sayaka、Hisamatsu Takashi、Miyazawa Itsuko、Kondo Keiko、Tooyama Ikuo、Miura Katsuyuki、Ueshima Hirotsugu、for the SESSA Research Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 12 Pages: 1102-1114
  • DOI: 10.5551/jat.47977
  • NAID: 130007754392
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-12-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men (2019)
  • Author(s): Kimani Cecilia、Kadota Aya、Miura Katsuyuki、Fujiyoshi Akira、Zaid Maryam、Kadowaki Sayaka、Hisamatsu Takashi、Arima Hisatomi、Horie Minoru、Ueshima Hirotsugu、for the SESSA Research Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 5 Pages: 452-464
  • DOI: 10.5551/jat.44784
  • NAID: 130007641278
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-05-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: a population‐based study (2019)
  • Author(s): Hisamatsu T.、Miura K.、Fujiyoshi A.、Kunimura A.、Ito T.、Miyazawa I.、Torii S.、Shiino A.、Nozaki K.、Kanda H.、Arima H.、Ohkubo T.、Ueshima H.、on behalf of the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group
  • Journal Title: European Journal of Neurology Volume: [Epub ahead of print] Issue: 9 Pages: 1219-1225
  • DOI: 10.1111/ene.13970
  • Peer Reviewed / Open Access
• [Journal Article] Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men (2019)
  • Author(s): Shitara Satoshi、Fujiyoshi Akira、Hisamatsu Takashi、Torii Sayuki、Suzuki Sentarou、Ito Takahiro、Arima Hisatomi、Shiino Akihiko、Nozaki Kazuhiko、Miura Katsuyuki、Ueshima Hirotsugu、for the SESSA Research group
  • Journal Title: Stroke Volume: 50 Issue: 10 Pages: 2967-2969
  • DOI: 10.1161/strokeaha.119.025964
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Coronary Artery Calcium Progression Among the US and Japanese Men (2019)
  • Author(s): Hisamatsu Takashi、Liu Kiang、Chan Cheeling、Krefman Amy E.、Fujiyoshi Akira、Budoff Matthew J.、Miura Katsuyuki、Lloyd-Jones Donald M.、Ueshima Hirotsugu
  • Journal Title: Circulation: Cardiovascular Imaging Volume: 12 Issue: 2
  • DOI: 10.1161/circimaging.118.008104
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2018)
  • Author(s): Seto-Yukimura R, Ogawa E, Hisamatsu T, Torii S, Shiino A, Nozaki K, Fujiyoshi A, Miura K, Nakano Y, Ueshima H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 10 Pages: 1009-1021
  • DOI: 10.5551/jat.42127
  • NAID: 130007493888
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-10-01
  • Peer Reviewed / Open Access
• [Journal Article] Change in Pericardial Fat Volume and Cardiovascular Risk Factors in a General Population of Japanese Men (2018)
  • Author(s): Miyazawa Itsuko、Ohkubo Takayoshi、Kadowaki Sayaka、Fujiyoshi Akira、Hisamatsu Takashi、Kadota Aya、Arima Hisatomi、Budoff Matthew、Murata Kiyoshi、Miura Katsuyuki、Maegawa Hiroshi、Ueshima Hirotsugu、for the SESSA Research Group
  • Journal Title: Circulation Journal Volume: 82 Issue: 10 Pages: 2542-2548
  • DOI: 10.1253/circj.CJ-18-0153
  • NAID: 130007490057
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-09-25
  • Peer Reviewed
• [Journal Article] Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2018)
  • Author(s): Tai P, Fujiyoshi A, Arima H, Tanaka-Mizuno S, Hisamatsu T, Kadowaki S, Kadota A, Zaid M, Sekikawa A, Yamamoto T, Horie M, Miura K, Ueshima H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 6 Pages: 477-489
  • DOI: 10.5551/jat.42416
  • NAID: 130007382558
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-06-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Home blood pressure variability and subclinical atherosclerosis in multiple vascular beds (2018)
  • Author(s): Hisamatsu Takashi、Miura Katsuyuki、Ohkubo Takayoshi、Arima Hisatomi、Fujiyoshi Akira、Satoh Atsushi、Kadota Aya、Zaid Maryam、Takashima Naoyuki、Ohno Seiko、Horie Minoru、Ueshima Hirotsugu
  • Journal Title: Journal of Hypertension Volume: 36 Issue: 11 Pages: 2193-2203
  • DOI: 10.1097/hjh.0000000000001810
  • Peer Reviewed / Open Access
• [Journal Article] Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men (2018)
  • Author(s): Sekikawa Akira、Mahajan Hemant、Kadowaki Sayaka、Hisamatsu Takashi、Miyagawa Naoko、Fujiyoshi Akira、Kadota Aya、Maegawa Hiroshi、Murata Kiyoshi、Miura Katsuyuki、Edmundowicz Daniel、Ueshima Hirotsugu
  • Journal Title: European Journal of Clinical Nutrition Volume: 73 Issue: 5 Pages: 783-792
  • DOI: 10.1038/s41430-018-0242-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study. (2018)
  • Author(s): Hisamatsu T, Miura K, Fujiyoshi A, Kadota A, Miyagawa N, Satoh A, Zaid M, Yamamoto T, Horie M, Ueshima H.
  • Journal Title: Atherosclerosis Volume: 未定 Pages: 145-152
  • DOI: 10.1016/j.atherosclerosis.2018.03.035
  • Peer Reviewed
• [Journal Article] Step counts measured with a pedometer and risk of incident metabolic syndrome: a 5-year follow-up of population-based cohort. (2017)
  • Author(s): Hisamatsu T, Miura K, Shibukawa T, Fujiyoshi A, Miyagawa N, Sayuki T, Kondo K, Miyazawa I, Suzuki S, Satoh A, Yamazoe M, Yanagita M, Maegawa H, Ueshima H; SESSA Research Group.
  • Journal Title: JJCDP Volume: 52 Pages: 20-28
  • Peer Reviewed
• [Journal Article] Increased aortic calcification is associated with arterial stiffness progression in multi ethnic middle-aged men. (2017)
  • Author(s): Guo J, Fujiyoshi A, Willcox B, Choo J, Vishnu A, Hisamatsu T, Ahuja V, Takashima N, Barinas-Mitchell E, Kadota A, Evans RW, Miura K, Edmundowicz D, Masaki K, Shin C, Kuller LH, Ueshima H, Sekikawa A
  • Journal Title: Hypertension Volume: 69 Pages: 102-108
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Relationship of four blood pressure indexes to subclinical cerebrovascular diseases assessed by brain MRI in general Japanese men (2020)
  • Author(s): Salman E, AKadota A, Hisamatsu T, Segawa H, Torii S, Fujiyoshi A, Kondo K, Arima H, Shiino A, Miura K, Ueshima H
  • Organizer: American Heart Association EPI/LIFESTYLE 2020 Scientific Sessions
  • Int'l Joint Research
• [Presentation] Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: A population-based study (2019)
  • Author(s): Hisamatsu T, Miura K, Fujiyoshi A, Kunimura A, Shiino A, Nozaki K, Arima H, Ohkubo T, Ueshima H
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2019)
  • Author(s): Hisamatsu T, Ohkubo T, Kadota A, Fujiyoshi A, Miura K, Ueshima H
  • Organizer: IDACO/IDHOCO/IDCARS Consortium Meeting 2019
  • Int'l Joint Research / Invited
• [Presentation] Serum levels of LOX-1 ligand containing ApoAI are associated with coronary artery calcification in middle-aged Japanese men (2019)
  • Author(s): Hirata A, Kakino A, Okamura T, Usami Y, Fujita Y, Kadota A, Fujiyoshi A, Hisamatsu T, Sawamura T, Miura K, Ueshima H
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Relationship of four blood pressure indexes to subclinical cerebrovascular diseases assessed by brain MRI in general Japanese men (2019)
  • Author(s): Salman E, AKadota A, Hisamatsu T, Segawa H, Torii S, Fujiyoshi A, Kondo K, Arima H, Shiino A, Miura K, Ueshima H
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: A population-based study (2019)
  • Author(s): Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Ayako Kunimura, Akihiko Shiino, Kazuhiko Nozaki, Hisatomi Arima, Takayoshi Ohkubo, Hirotsugu Ueshima
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Coronary artery calcium progression among the United States and Japanese men: MESA and SESSA (2019)
  • Author(s): Takashi Hisamatsu
  • Organizer: Cardiovascular Epidemiology Seminar Series. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine.
  • Int'l Joint Research / Invited
• [Presentation] CT-based Obesity Indices were Not Stronger than Anthropometric Obesity Indices in the Association with Carotid Intima-media Thickness In Community-dwelling Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (2018)
  • Author(s): Liu Y; Fujiyoshi A, Arima H, Kadota A, Kadowaki S, Hisamatsu T, Miyazawa I, Kondo K, Miura K, Ueshima H
  • Organizer: 第29回日本疫学会学術集会
• [Presentation] 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連:滋賀動脈硬化疫学研究SESSA (2017)
  • Author(s): 久松隆史、三浦克之、有馬久富、門田文、門脇紗也佳、鳥居さゆ希、鈴木仙太朗、宮川尚子、佐藤敦、藤吉朗、大久保孝義、Abbott D. Robert、関川暁、堀江稔、上島弘嗣
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] Objectively measured step counts was independently associated with higher cognition in apparently healthy Japanese men: SESSA study (2017)
  • Author(s): Takeshi Shibukawa, Akira Fujiyoshi, Katsuyuki Miura, Naoko Miyagawa, Yoshino Saito, Maryam Zaid, Takashi Hisamatsu, Takayoshi Ohkubo, Hisatomi Arima, Ikuo Tooyama, Hirotsugu Ueshima
  • Organizer: AHA EPI Lifestyle 2018 Scientific Sessions
  • Int'l Joint Research
• [Presentation] 日本人一般男性における飲酒習慣と肥満指標・腹部脂肪分布(内臓脂肪・皮下脂肪)との関連 (2017)
  • Author(s): 炭昌樹，久松隆史，藤吉朗，門田文，宮川尚子，近藤慶子，門脇紗也佳，鈴木仙太朗，鳥居さゆ希，Zaid Maryam，佐藤敦，有馬久富，三浦克之，上島弘嗣
  • Organizer: 第53回日本循環器病予防学会学術集会
• [Presentation] Smoking associates with higher incidence and progression of coronary atherosclerosis in a community-based sample of Japanese men (2017)
  • Author(s): Pham Tai, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Kadowaki Sayaka, Zaid Maryam, Horie Minoru, Miura Katsuyuki, Ueshima Hirotsugu
  • Organizer: 第52回日本アルコール・アディクション医学会学術集会
• [Presentation] 厳密な安静後の診察室血圧値と家庭血圧値の比較、及びその差に影響を及ぼす要因の検討 (2017)
  • Author(s): 門脇 紗也佳, 寳澤 篤, 藤吉 朗, 久松 隆史, 佐藤 敦, 田中 佐智子, 岡村 智教, 大久保 孝義, 三浦 克之, 上島 弘嗣
  • Organizer: 第40回日本高血圧学会総会
• [Remarks] 滋賀動脈硬化疫学研究
  • URL: https://shiga-publichealth.jp/sessa/
• [Remarks] 滋賀医科大学アジア疫学研究センター
  • URL: http://cera.shiga-med.ac.jp/
• [Remarks] 滋賀動脈硬化疫学研究 セッサ SESSA
  • URL: https://hs-web.shiga-med.ac.jp/sessa/index.html