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Challenges to the Dilemma of Sarcopenia and Renal Dysfunction in Patients with Chronic Heart Failure

Research Project

Project/Area Number 17K16027
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Suzuki Norio  聖マリアンナ医科大学, 医学部, 助教 (00770158)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords心不全 / サルコペニア / 腎機能障害 / 慢性腎臓病 / 慢性心不全 / アミノ酸摂取 / リハビリテーション / 栄養学 / 循環器・高血圧
Outline of Final Research Achievements

In addition to exercise therapy, adequate protein-containing nutrients are important to prevent the development and progression of sarcopenia in heart failure patients, but protein restriction is required for some patients with chronic kidney disease (CKD). This results in inadequate protein intake and an increased risk of developing or progressing to sarcopenia.
Leucine-enriched amino acid-containing jellies are effective in preventing or improving sarcopenia by increasing skeletal muscle mass and improving muscle strength with smaller amounts than the usual dietary protein intake. In hospitalized heart failure patients with CKD who underwent cardiac rehabilitation, leucine-enriched amino acid-containing jelly could be safely consumed in addition to dietary intake without progression of renal dysfunction.

Academic Significance and Societal Importance of the Research Achievements

CKDを合併した心不全では、腎機能障害の進行リスクを増加させず、サルコペニアに対する効果的な食事療法として、至適たんぱく質摂取量が不明であった。たんぱく質制限を要するCKD患者に対して、ロイシン強化型アミノ酸含有ゼリーは筋蛋白の合成に必要なアミノ酸を効率的に少量で摂取することができ、たんぱく質過剰摂取による腎機能障害の進行を防ぐことが可能であった。CKDを合併した心不全患者に対して、ロイシン強化型アミノ酸含有ゼリーの付加は、CKDの悪化やサルコペニアによる生命予後やADL、医療費、介護負担などに与える影響を改善することにつながる可能がある。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (16 results)

All 2021 2020 2019 2018 2017

All Presentation (16 results) (of which Int'l Joint Research: 5 results,  Invited: 7 results)

  • [Presentation] 心血管疾患の栄養管理 -2021年改訂版心リハガイドラインをふまえて-2021

    • Author(s)
      鈴木規雄
    • Organizer
      第69回心臓病学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 重症患者の栄養療法2020

    • Author(s)
      鈴木規雄
    • Organizer
      第26回日本心臓リハビリテーション学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 心不全患者の栄養評価の重要性2020

    • Author(s)
      鈴木規雄
    • Organizer
      第24回日本心不全学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 臨床現場における心臓悪液質に対するアプローチ2019

    • Author(s)
      鈴木規雄
    • Organizer
      第34回日本静脈経腸栄養学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 腸管の変化に伴う心臓悪液質の病態およびスクリーニング2019

    • Author(s)
      鈴木規雄、木田圭亮、中山由衣、笠原みづほ、桒田真吾、髙井学、松田央郎、水野幸一、明石嘉浩
    • Organizer
      第6回日本サルコペニア・悪液質・消耗性疾患研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Mini Nutritional Assessment Short Form and Kihon checklist are simple and useful screening for cardiac cachexia in outpatients with heart failure.2019

    • Author(s)
      Norio Suzuki, Keisuke Kida, Shunichi Doi, Yui Nakayama, Mizuho Kasahara, Kazuaki Okuyama, Kei Mizukoshi, Kohei Ashikaga, Hisao Matsuda, Koichi Mizuno, Tomoo Harada, Yoshihiro J Akashi
    • Organizer
      ESPEN 2019 Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 栄養管理のポイント2019

    • Author(s)
      鈴木規雄
    • Organizer
      第67回日本心臓病学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 心不全患者における栄養評価・管理の重要性2019

    • Author(s)
      鈴木規雄
    • Organizer
      第23回日本心不全学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Evaluation of useful and convenient screening methods for cardiac cachexia in outpatients with heart failure2019

    • Author(s)
      Norio Suzuki, Keisuke Kida, Shunichi Doi, Kohei Ashikaga, Hisao Matsuda, Koichi Mizuno, Tomoo Harada, Yoshihiro J. Akashi
    • Organizer
      12th International Conference on Cachexia, Sarcopenia& Muscle Wasting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Heart failure severity, low blood pressure, low handgrip strength and malnutrition are the predictive factors for frailty in patients with chronic heart failure in Japan2018

    • Author(s)
      Norio Suzuki, Keisuke Kida, Chikayuki Ito, Kohei Ashikaga, Kengo Suzuki, Kazuto Omiya, Tomoo Harada, Yoshihiro J. Akashi
    • Organizer
      Heart Failure 2018 & World Congress on Acute Heart Failure
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pros & Cons:重症心不全のリハビリテーション 栄養か?運動か?-栄養が優先-2018

    • Author(s)
      鈴木規雄
    • Organizer
      第24回日本心臓リハビリテーション学会 学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Depending on the difference in left ventricular ejection fraction, lower total cholesterol level can be a prognostic predictor in chronic heart failure patients2018

    • Author(s)
      N. Suzuki, K. Kida, S. Doi, C. Ito, K. Ashikaga, H. Matsuda, K. Mizuno, T. Harada, Y. J. Akashi
    • Organizer
      ESPEN 2018 Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 二次性サルコペニアと医原性サルコペニア2018

    • Author(s)
      鈴木規雄
    • Organizer
      第5回日本サルコペニア・フレイル学会大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 最新栄養学2018

    • Author(s)
      鈴木規雄
    • Organizer
      第3回日本心臓リハビリテーション学会関東甲信越支部地方会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Low blood pressure in heart failure patients with underweight is the predictive factor of mortality and risk factor of frailty2018

    • Author(s)
      Norio Suzuki, Keisuke Kida, Shunichi Doi, Chikayuki Ito, Yui Nakayama, Mizuho Kasahara, Shingo Kuwata, Kohei Ashikaga, Manabu Takai, Hisao Matsuda, Koichi Mizuno, Tomoo Harada, Yoshihiro J. Akashi
    • Organizer
      11th Cachexia Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心不全患者の骨格筋量と各栄養指標の関連-BMIと血液学的指標は骨格筋量を反映するか?-2017

    • Author(s)
      鈴木規雄
    • Organizer
      第23回日本心臓リハビリテーション学会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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