| Project/Area Number |
17K16091
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
Uneda Kazushi 横浜市立大学, 医学部, 助教 (90780370)
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| Research Collaborator |
Tamura Kouichi
Wakui Hiromichi
Kinguchi Sho
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | レニン・アンジオテンシン系 / 腎内レニン・アンジオテンシン系 / ATRAP / 高血圧 / 慢性腎臓病 / AT1受容体 / アンジオテンシンII / 循環器・高血圧 |
|---|
| Outline of Final Research Achievements |
In this study, we generated proximal tubule-specific ATRAP KO mice. Detailed analysis of renal ATRAP expression revealed that ATRAP mRNA expression was decreased by nearly 80% in proximal regions of the nephron in proximal tubule-specific ATRAP KO mice compared with wild-type mice. There were no significant differences in blood pressure, urinary sodium retention and kidney damages between proximal tubule-specific ATRAP KO mice and wild-type mice under conditions of chronic angiotensin II stimulation. These results indicate that renal proximal tubule ATRAP has a minor role in angiotensin-mediated hypertension or kidney injury.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の検討により，近位尿細管特異的ATRAP欠損マウスではアンジオテンシンII依存性高血圧・腎障害の増悪を認めないことが明らかとなった．尿細管のATRAPに関する既報と今回の結果を総合すると，近位尿細管におけるATRAPがアンジオテンシンII依存性高血圧・腎障害の病態に及ぼす影響は少なく，むしろ遠位尿細管に存在するATRAPが重要である可能性が想起された．
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