Role of Polycomb potentiates in acute kidney disease
| Project/Area Number |
17K16103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 急性腎障害 / ポリコームグループタンパク質 / SCMH1 / 虚血耐性 / 腎保護作用 / 腎臓内科 / 腎臓 / 内科 / 細胞・組織 |
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| Outline of Final Research Achievements |
Frequency of onset of iatrogenic acute kidney injury (AKI) is increasing under development of medical technology in as aging society. However, such a AKI has few curative treatments. The aim of this study was to reveal a role of polycomb group protein (Bmi1 and SCMH1) under hypoxia which is a main cause of iatrogenic AKI. Because proximal tubular cells are principle target for the AKI, human proximal tubular cells (HK2 cells) were used. Down-regulation of SCMH1 by siRNA for SCMH1 induced increase in cytotoxicity and decrease in cell survival rate. However, such a result was not found by down-regulation of Bmi1 by siRNA for Bmi1.The SCMH1 expressed in the proximal tubule may have a protective effect against hypoxia.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢者の増加、医療技術の進歩により、医原性の急性腎障害(AKI)の発症頻度が、世界的に増加しているものの、その有効な治療法がないため、ポリコームグループタンパク質（PRC1構成蛋白 Bmi1およびSCMH1)に着目し、その細胞保護作用の有無を検討した。その結果、SCMH1が、腎保護的に作用する事が明らかになった。SCMH1の発現増強は、AKI治療に有効である可能性があり、さらなる検討を行う。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Relationship between urinary liver-type fatty acid-binding protein (L-FABP) and sarcopenia in spontaneously diabetic Torii fatty rats.2020
Author(s)
Tanabe J, Ogura Y, Kosaki K, Nagai Y, Sugaya T, Ohata K, Watanabe S, Ichikawa D, Inoue K, Hoshino S, Kimura K, Maeda S, Shibagaki Y, Kamijo-Ikemori A.
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Journal Title
Journal of Diabetes Research
Volume: -
NAID
Related Report
Peer Reviewed / Open Access
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