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Elucidation of glucose, lipid and bone metabolism by an estrogen-inducible mitochondrial respiratory supercomplex assembly factor

Research Project

Project/Area Number 17K16170
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionSaitama Medical University

Principal Investigator

Shiba Sachiko  埼玉医科大学, 医学部, 研究員 (70633824)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsミトコンドリア / エストロゲン応答遺伝子 / 遺伝子改変マウス / 糖代謝 / 脂質代謝 / COX7RP / 呼吸鎖複合体
Outline of Final Research Achievements

Estrogen, a female hormone, is involved in the regulation of various metabolism; however, the molecular mechanism remains to be elucidated. COX7RP has been identified as an estrogen-responsive gene and recently reported as a stimulating factor for mitochondrial respiratory supercomplex assembly. In this study, physiological function of COX7RP was analyzed using gene-modified mouse model. COX7RP knockout mice (Cox7rpKO) showed low blood glucose levels and reduced gluconeogenesis. In addition, mitochondrial respiratory supercomplex formation and ATP synthesis were decreased in mitochondria prepared from the liver of Cox7rpKO. These results suggest that COX7RP plays an important role in glucose metabolism.

Academic Significance and Societal Importance of the Research Achievements

エストロゲンは様々な代謝系の調節に関与しており、そのメカニズムの解明は肥満、糖尿病、脂質代謝異常などの治療に役立つ可能性が想定される。本研究によって、エストロゲン作用とミトコンドリア機能との接点となるCOX7RP が糖代謝に重要な役割を担っていることを解明したことは、内分泌学をはじめとする医学、生物学に新しい研究分野を拓くものと考えられる。また、COX7RPの機能解明は、上記疾患等の病因解明と新たな予防・治療法への応用が期待され、社会的にも生活習慣病の改善や健康維持などに資すると期待できる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice2017

    • Author(s)
      Shiba Sachiko、Ikeda Kazuhiro、Horie-Inoue Kuniko、Nakayama Akitoshi、Tanaka Tomoaki、Inoue Satoshi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 7606-7606

    • DOI

      10.1038/s41598-017-08081-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Establishment of patient-derived cells and xenografts of endometrial cancer using a long-term culture based on spheroid formation2019

    • Author(s)
      Inoue S, Shiba S, Ikeda K, Horie-Inoue K
    • Organizer
      The 11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 患者由来子宮内膜がん三次元培養とPatient-Derived Xenograft(PDX)モデルの樹立2018

    • Author(s)
      柴 祥子、池田 和博、鈴木 貴、新谷 大輔、岡本 康司、堀江 公仁子、長谷川 幸清、井上 聡
    • Organizer
      第19回ホルモンと癌研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 女性ホルモンに応答する患者由来子宮内膜がん培養・移植モデルの確立とそのメカニズムの解析2018

    • Author(s)
      柴 祥子、池田 和博、鈴木 貴、新谷 大輔、岡本 康司、堀江 公仁子、長谷川 幸清、井上 聡
    • Organizer
      第26回日本ステロイドホルモン学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 患者由来子宮内膜がん三次元スフェロイド培養とマウス移植モデルの確立およびそのホルモン・薬剤反応性の解析2018

    • Author(s)
      柴 祥子、池田 和博、鈴木 貴、堀江 公仁子、新谷 大輔、岡本 康司、長谷川 幸清、井上 聡
    • Organizer
      第2回がん三次元培養研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 子宮内膜がんのスフェロイド培養と細胞増殖抑制法の検討2017

    • Author(s)
      柴 祥子、池田和博、堀江公仁子、滑川剛史、新谷大輔、 岡本康司、長谷川幸清、井上 聡
    • Organizer
      第1回がん三次元培養研究会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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