LncRNA in labial salivary glands of Sjogren's syndrome patients

• Project/Area Number: 17K16210
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
• Principal Investigator: HORAI Yoshiro 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 自己免疫研究室長 (30646782)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: シェーグレン症候群 / long non-coding RNA / NRON / NFATc1 / PIM-1 / NFATｃ１ / 免疫学

Outline of Final Research Achievements

The expressions of NRON and related substances were examined by in situ hybridisation, immunohistochemical analysis and immunofluorescence in labial salivary glands (LSGs) obtained from patients with Sjogren's syndrome (SS) and control subjects. The NRON expression in the nuclei of cell infiltration lesions of the SS patients were prominent. The NFATc1 expression was strong in the cytoplasm of infiltrating mononuclear cells and weak in ducts of both SS and controls. In SS, the NFATc1-positive area/infiltrating cell area was positively correlated with the infiltrating cell area and focus score. CD3/CD4 was expressed in infiltrating mononuclear cells, and PIM-1 colocalised with NFATc1 in the cytoplasm. These results suggest NRON along with NFATc1/PIM-1 in SS LSGs might participates in SS pathophysiology.

Academic Significance and Societal Importance of the Research Achievements

LncRNAの発現及び機能解析は自己免疫疾患を含めた様々な病態に対する特異的な治療法に直結することが期待されている。本研究はSSの病変主座である小唾液腺におけるlncRNAと関連分子の局在を含めた発現解析、及びそれらの病態への関与を示す最初の報告であるため、今回の成果はSSにおける疾患特異的治療ターゲットの同定につながることが期待される。

Research Products

• [Journal Article] Clinical Characteristics of Patients With IgG4-Related Disease Complicated by Hypocomplementemia (2022)
  • Author(s): Fujita Yuya、Fukui Shoichi、Umeda Masataka、Tsuji Sosuke、Iwamoto Naoki、Nakashima Yoshikazu、Horai Yoshiro、Suzuki Takahisa、Okada Akitomo、Aramaki Toshiyuki、Ueki Yukitaka、Mizokami Akinari、Origuchi Tomoki、Watanabe Hiroshi、Migita Kiyoshi、Kawakami Atsushi
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 828122-828122
  • DOI: 10.3389/fimmu.2022.828122
  • Peer Reviewed / Open Access
• [Journal Article] Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sj?gren’s Syndrome Patients (2021)
  • Author(s): Horai Yoshiro、Nakamura Hideki、Shimizu Toshimasa、Nishihata Shinya、Iwamoto Naoki、Kuroki Tamotsu、Okano Shinji、Kawakami Atsushi
  • Journal Title: Applied Immunohistochemistry & Molecular Morphology Volume: 29 Issue: 10 Pages: 734-740
  • DOI: 10.1097/pai.0000000000000959
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the quantitative measurement of 18F-FDG PET/CT and histopathological findings in IgG4-related disease. (2021)
  • Author(s): Tsuji S, Iwamoto N, Horai Y, et al.
  • Journal Title: Clin Exp Rheumatol. Volume: 39 Pages: 1338-1344
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• [Journal Article] IgA Vasculitis Triggered by Infective Endocarditis of Pulmonary Artery with Congenitally Corrected Transposition of the Great Arteries (2020)
  • Author(s): Akagi Midori、Iwanaga Nozomi、Torisu Yuichi、Fujita Hisayuki、Kawahara Chieko、Horai Yoshiro、Izumi Yasumori、Kawakami Atsushi
  • Journal Title: International Heart Journal Volume: 61 Issue: 2 Pages: 404-408
  • DOI: 10.1536/ihj.19-446
  • NAID: 130007821505
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  • Year and Date: 2020-03-28
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• [Journal Article] Clinical analysis of pre-existing diabetes mellitus and dipeptidyl peptidase-4 inhibitors in patients with remitting seronegative symmetrical synovitis and pitting edema syndrome (2020)
  • Author(s): Horai Yoshiro、Origuchi Tomoki、Iwanaga Nozomi、Tokumitsu Junichi、Ikeoka Toshiyuki、Kuriya Genpei、Izumi Yasumori、Kawakami Atsushi
  • Journal Title: Modern Rheumatology Volume: 30 Issue: 4 Pages: 703-707
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• [Journal Article] Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort (2020)
  • Author(s): Ichinose Kunihiro、Kitamura Mineaki、Sato Shuntaro、Fujikawa Keita、Horai Yoshiro、Matsuoka Naoki、Tsuboi Masahiko、Nonaka Fumiaki、Shimizu Toshimasa、Sumiyoshi Remi、Koga Tomohiro、Kawashiri Shin-ya、Iwamoto Naoki、Igawa Takashi、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Nishino Tomoya、Kawakami Atsushi
  • Journal Title: Arthritis Research & Therapy Volume: 22 Issue: 1 Pages: 175-175
  • DOI: 10.1186/s13075-020-02271-3
  • NAID: 120006988113
  • Peer Reviewed / Open Access
• [Journal Article] Development of hypocomplementemic urticarial vasculitis during certolizumab pegol treatment for rheumatoid arthritis: A case report (2020)
  • Author(s): Horai Yoshiro、Ishikawa Hiroshi、Iwanaga Nozomi、Izumi Yasumori、Matsuoka Yuki、Miura Shiro、Kawakami Atsushi
  • Journal Title: Journal of Clinical Pharmacy and Therapeutics Volume: 45 Issue: 5 Pages: 1179-1182
  • DOI: 10.1111/jcpt.13117
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• [Journal Article] IL‐15 is a biomarker involved in the development of rapidly progressive interstitial lung disease complicated with polymyositis/dermatomyositis (2020)
  • Author(s): Shimizu T.、Koga T.、Furukawa K.、Horai Y.、Fujikawa K.、Okada A.、Okamoto M.、Endo Y.、Tsuji S.、Takatani A.、Umeda M.、Fukui S.、Sumiyoshi R.、Kawashiri S.‐y.、Iwamoto N.、Igawa T.、Ichinose K.、Tamai M.、Sakamoto N.、Nakamura H.、Origuchi T.、Mukae H.、Kuwana M.、Kawakami A.
  • Journal Title: Journal of Internal Medicine Volume: 289 Issue: 2 Pages: 206-220
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• [Journal Article] Rheumatoid arthritis patients with low baseline Health Assessment Questionnaire scores have a risk of functional disability progression: a post hoc analysis of a nationwide longitudinal cohort in Japan (2020)
  • Author(s): Sumiyoshi, R., Hidaka, T., Koga, T., Okada, A., Fukuda, T., Ishii, T., Ueki, Y., Kodera, T., Nakashima, M., Takahashi, Y., Honda, S., Horai, Y., Watanabe, R., Okuno, H., Aramaki, T., Izumiyama, T., Takai, O., Miyashita, T., Kawashiri, S. Y., Iwamoto, N., … and the Japanese RA Patients with RRP Study Group
  • Journal Title: Clinical and experimental rheumatology Volume: 38(6) Pages: 1096-1101
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• [Journal Article] Giant Cell Arteritis with Generalized Granuloma Annulare (2019)
  • Author(s): Torisu Yuichi、Horai Yoshiro、Michitsuji Tohru、Kawahara Chieko、Mori Takahiro、Iwanaga Nozomi、Izumi Yasumori、Kawakami Atsushi
  • Journal Title: Internal Medicine Volume: 58 Issue: 8 Pages: 1173-1177
  • DOI: 10.2169/internalmedicine.1978-18
  • NAID: 130007632727
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-04-15
  • Peer Reviewed / Open Access
• [Journal Article] Activation of Toll‐like receptor 7 signaling in labial salivary glands of primary Sj?gren's syndrome patients (2019)
  • Author(s): Shimizu T.、Nakamura H.、Takatani A.、Umeda M.、Horai Y.、Kurushima S.、Michitsuji T.、Nakashima Y.、Kawakami A.
  • Journal Title: Clinical & Experimental Immunology Volume: 196 Issue: 1 Pages: 39-51
  • DOI: 10.1111/cei.13242
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• [Journal Article] Swollen joints and peripheral arthritis are signs of malignancy in polymyalgia rheumatica (2019)
  • Author(s): Michitsuji Tohru、Iwanaga Nozomi、Horai Yoshiro、Tsuji Yoshika、Kawahara Chieko、Izumi Yasumori、Taniguchi Ken、Yoshida Shinichiro、Kawakami Atsushi
  • Journal Title: Modern Rheumatology Volume: 29 Issue: 6 Pages: 1013-1016
  • DOI: 10.1080/14397595.2018.1538027
  • Peer Reviewed
• [Journal Article] Factors predictive of long-term mortality in lupus nephritis: a multicenter retrospective study of a Japanese cohort (2019)
  • Author(s): Ichinose K、Kitamura M、Sato S、Fujikawa K、Horai Y、Matsuoka N、Tsuboi M、Nonaka F、Shimizu T、Fukui S、Umeda M、Koga T、Kawashiri S、Iwamoto N、Tamai M、Nakamura H、Origuchi T、Nishino T、Kawakami A
  • Journal Title: Lupus Volume: 28 Issue: 3 Pages: 295-303
  • DOI: 10.1177/0961203319826690
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• [Journal Article] A case of simultaneously diagnosed microscopic polyangiitis and lung adenocarcinoma (2019)
  • Author(s): Kawaguchi Y, Iwanaga N, Michitsuji T, Kawahara C, Horai Y, Mori H, Nagayoshi Y, Izumi Y, Ito M, Kawakami A.
  • Journal Title: Acta Med Nagasaki Volume: 62 Pages: 69-72
  • NAID: 130007683977
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• [Journal Article] Efficacy of infliximab as a switched biologic in rheumatoid arthritis patients in daily clinical practice (2018)
  • Author(s): Umeda Masataka、Koga Tomohiro、Ichinose Kunihiro、Takatani Ayuko、Igawa Takashi、Shimizu Toshimasa、Fukui Shoichi、Nishino Ayako、Horai Yoshiro、Hirai Yasuko、Kawashiri Shin-Ya、Iwamoto Naoki、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Aramaki Toshiyuki et al.
  • Journal Title: Immunological Medicine Volume: 41 Issue: 4 Pages: 181-186
  • DOI: 10.1080/25785826.2018.1542942
  • Peer Reviewed / Open Access
• [Journal Article] Serum cytokine profiles and Mac-2 binding protein glycosylation isomer (M2BPGi) level in patients with autoimmune hepatitis (2018)
  • Author(s): Migita K, Horai Y, Kozuru H, Koga T, Abiru S, Yamasaki K, et al.
  • Journal Title: Medicine Volume: 97 Issue: 50 Pages: e13450-e13450
  • DOI: 10.1097/md.0000000000013450
  • NAID: 120007128247
  • Peer Reviewed / Open Access
• [Journal Article] Podocyte foot process width is a prediction marker for complete renal response at 6 and 12 months after induction therapy in lupus nephritis. (2018)
  • Author(s): Ichinose K, Kitamura M, Sato S, Fujikawa K, Horai Y, Matsuoka N, Tsuboi M, Nonaka F, Shimizu T, Fukui S, Umeda M, Koga T, Kawashiri SY, Iwamoto N, Igawa T, Tamai M, Nakamura H, Origuchi T, Nishino T, Kawakami A.
  • Journal Title: Clin Immunol. Volume: 197 Pages: 161-168
  • DOI: 10.1016/j.clim.2018.10.002
  • Peer Reviewed / Open Access
• [Journal Article] Anti-SS-A antibody-negative/anti-SS-B antibody-positive Sjögren's syndrome with increased serum concentration and lymph node infiltration of immunoglobulin G4: a case report (2018)
  • Author(s): Horai Y, Izumi Y, Michitsuji T, Iwanaga N, Nakashima Y, Nakamura H, Ito M, Kawakami A.
  • Journal Title: Clin Rheumatol Rel Res Volume: 30 Pages: 276-83
  • Peer Reviewed
• [Journal Article] Development of Diffuse Alveolar Hemorrhage during Maintenance Therapy for Systemic Lupus Erythematosus: a Case Report (2018)
  • Author(s): Horai Y, Michitsuji T, Chikamatsu G, Moritsuka T, Torisu Y, Kubota Y, Iwanaga N, Iwanaga N, Izumi Y.
  • Journal Title: Clin Rheumatol Rel Res Volume: 30 Pages: 175-82
  • NAID: 130007657461
  • Peer Reviewed
• [Journal Article] Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sj?gren’s Syndrome (2018)
  • Author(s): Nakamura Hideki、Horai Yoshiro、Shimizu Toshimasa、Kawakami Atsushi
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Issue: 8 Pages: 2369-2369
  • DOI: 10.3390/ijms19082369
  • Peer Reviewed / Open Access
• [Journal Article] The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus (2018)
  • Author(s): Ichinose K、Sato S、Kitajima Y、Horai Y、Fujikawa K、Umeda M、Fukui S、Nishino A、Koga T、Kawashiri S Y、Iwamoto N、Tamai M、Nakamura H、Origuchi T、Yasuhi I、Masuzaki H、Kawakami A
  • Journal Title: Lupus Volume: - Issue: 8 Pages: 1312-1320
  • DOI: 10.1177/0961203318770536
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Therapeutic effect of certolizumab pegol in patients with rheumatoid arthritis in daily clinical practice: A single-center, retrospective study (2018)
  • Author(s): Horai Y, IwanagaN, Izumi Y, Migita K.
  • Journal Title: Clin Rheumatol Rel Res Volume: 30 Pages: 98-106
  • NAID: 130007502007
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• [Journal Article] Detection of human T lymphotropic virus type-I bZIP factor and tax in the salivary glands of Sjögren's syndrome patients (2018)
  • Author(s): 11.Nakamura H, Hasegawa H, Sasaki D, Takatani A, Shimizu T, Kurushima S, Horai Y, Nakashima Y, Nakamura T, Fukuoka J, Kawakami A.
  • Journal Title: Clin Exp Rheumatol Volume: 36 Suppl 112 Pages: 51-60
  • Peer Reviewed
• [Journal Article] Combined classification system based on ACR/EULAR and ultrasonographic scores for improving the diagnosis of Sjogren's syndrome (2018)
  • Author(s): Takagi Y, Nakamura H, Sumi M, Shimizu T, Horai Y, Eida S, Sasaki M, Nakamura T
  • Journal Title: PLOS ONE Volume: 13 Issue: 4 Pages: 1-15
  • DOI: 10.1371/journal.pone.0195113
  • NAID: 120006987320
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• [Journal Article] Protein-losing gastroenteropathy in a patient with concomitant systemic lupus erythematosus and Sjögren’s syndrome (2018)
  • Author(s): Eguchi M, Iwanaga N, Sakai K, Michitsuji T, Tsuji Y, Kawahara C, Kobayashi H, Horai Y, Mori T, Izumi Y, Ito M, Kawakami A.
  • Journal Title: Immunological Medicine Volume: 41 Issue: 1 Pages: 34-38
  • DOI: 10.1080/09114300.2018.1451614
  • Peer Reviewed / Open Access
• [Journal Article] M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis (2018)
  • Author(s): Fukui Shoichi、Iwamoto Naoki、Takatani Ayuko、Igawa Takashi、Shimizu Toshimasa、Umeda Masataka、Nishino Ayako、Horai Yoshiro、Hirai Yasuko、Koga Tomohiro、Kawashiri Shin-ya、Tamai Mami、Ichinose Kunihiro、Nakamura Hideki、Origuchi Tomoki、Masuyama Ritsuko、Kosai Kosuke、Yanagihara Katsunori、Kawakami Atsushi
  • Journal Title: Frontiers in Immunology Volume: 8 Pages: 1958-1958
  • DOI: 10.3389/fimmu.2017.01958
  • NAID: 120006987316
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus. (2018)
  • Author(s): Umeda M, Koga T, Ichinose K(corresponding author), Igawa T, Sato T, Takatani A, Shimizu T, Fukui S, Nishino A, Horai Y, Hirai Y, Kawashiri SY, Iwamoto N, Aramaki T, Tamai M, Nakamura H, Yamamoto K, Abiru N, Origuchi T, Ueki Y, Kawakami A.
  • Journal Title: Clin Immunol. Volume: 187 Pages: 50-57
  • DOI: 10.1016/j.clim.2017.10.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis (2017)
  • Author(s): Michitsuji T, Horai Y, Sako A, Asano T, Iwanaga N, Izumi Y, Kawakami A.
  • Journal Title: Japanese Journal of Clinical Immunology Volume: 40 Issue: 6 Pages: 467-470
  • DOI: 10.2177/jsci.40.467
  • NAID: 130006319725
  • ISSN: 0911-4300, 1349-7413
  • Peer Reviewed / Open Access
• [Journal Article] Steroid Treatment of Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Complicated by Pleural Effusion : A Case Report (2017)
  • Author(s): HORAI Y, MATSUO Y, TAKEMOTO S, IWANAGA N, IZUMI Y.
  • Journal Title: Fukuoka Igaku Zasshi Volume: 108 Pages: 217-222
  • NAID: 120006413995
  • Peer Reviewed / Open Access
• [Journal Article] Coexistence of Takayasu's arteritis and inflammatory colitis detected by fluorodeoxyglucose positron emission tomography (2017)
  • Author(s): Horai Y, Kurushima S, Igawa T, Ichinose K, Nakamura H, Kawakami A.
  • Journal Title: Japanese Journal of Clinical Immunology Volume: 40 Issue: 5 Pages: 387-390
  • DOI: 10.2177/jsci.40.387
  • NAID: 130006251854
  • ISSN: 0911-4300, 1349-7413
  • Peer Reviewed / Open Access
• [Journal Article] Phalangeal Microgeodic Syndrome in a Patient with Systemic Lupus Erythematosus (2017)
  • Author(s): Kurushima S, Horai Y, Takatani A, Nishino A, Kawashiri SY, Ichinose K, Nakamura H, Kawakami A
  • Journal Title: Internal Medicine Volume: 56 Issue: 24 Pages: 3385-3387
  • DOI: 10.2169/internalmedicine.9195-17
  • NAID: 130006250545
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Anti-transcription Intermediary Factor1γ-antibody-positive Dermatomyositis Complicated by Dysphagia (2017)
  • Author(s): Kurushima S, Horai Y, Umeda M, Kawakami A
  • Journal Title: Internal Medicine Volume: 56 Issue: 21 Pages: 2965-2966
  • DOI: 10.2169/internalmedicine.9149-17
  • NAID: 130006191979
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Anti-citrullinated peptide antibodies are the strongest predictor of clinically relevant radiographic progression in rheumatoid arthritis patients achieving remission or low disease activity: A post hoc analysis of a nationwide cohort in Japan (2017)
  • Author(s): Koga T, Okada A, Fukuda T, Hidaka T, Ishii T, Ueki Y, Kodera T, Nakashima M, Takahashi Y, Honda S, Horai Y, et al.
  • Journal Title: PLoS One Volume: 12 Issue: 5 Pages: e0175281-e0175281
  • DOI: 10.1371/journal.pone.0175281
  • NAID: 120006987476
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety at 24 weeks of daily clinical use of tofacitinib in patients with rheumatoid arthritis (2017)
  • Author(s): Iwamoto N, Tsuji S, Takatani A, Shimizu T, Fukui S, Umeda M, Nishino A, Horai Y, Koga T, Kawashiri SY, Aramaki T, Ichinose K, Hirai Y, Tamai M, Nakamura H, Terada K, Origuchi T, Eguchi K, Ueki Y, Kawakami A
  • Journal Title: PLoS One Volume: 12 Issue: 5 Pages: 0177057-0177057
  • DOI: 10.1371/journal.pone.0177057
  • NAID: 120006987500
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Baseline MRI bone erosion predicts the subsequent radiographic progression in early rheumatoid arthritis patients who achieved sustained good clinical response. (2017)
  • Author(s): Tamai M, Arima K, Nakashima Y, Kita J, Umeda M, Fukui S, Nishino A, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri SY, Iwamoto N, Ichinose K, Yamasaki S, Nakamura H, Origuchi T, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Journal Title: Mod Rheumatol Volume: 印刷中 Issue: 6 Pages: 1-6
  • DOI: 10.1080/14397595.2017.1294280
  • Peer Reviewed
• [Presentation] リウマチ性多発筋痛症の病態に対する性別と既存糖尿病の関与についての臨床的検討 (2022)
  • Author(s): 寶來 吉朗, 大塚 瑞奈, 川原 知瑛子, 岩永 希, 山﨑 悠介, 渡部 太郎, 安井 順一, 最勝寺 佑介, 鳥巣 裕一, 森 隆浩, 森 英毅, 和泉 泰衛, 川上 純
  • Organizer: 第63回九州リウマチ学会
• [Presentation] シェーグレン症候群小唾液腺における LncRNA NRON及びNFATc1関連分子発現の解析 (2021)
  • Author(s): 寶來 吉朗, 中村 英樹, 清水 俊匡, 西畑 伸哉, 岩本 直樹, 黒木 保, 岡野 慎士, 川上 純
  • Organizer: 第29回日本シェーグレン症候群学会
• [Presentation] 長崎県のRS3PE症候群患者における既存糖尿病と治療薬についての後ろ向き研究 (2021)
  • Author(s): 寶來 吉朗，清水 俊匡, 岡田 覚丈, 徳満 純一, 池岡 俊幸, 厨 源平, 岩永 希，和泉 泰衛，折口 智樹, 川上 純
  • Organizer: 第61回九州リウマチ学会
• [Presentation] LncRNA NRON upregulation associates with clinical manifestations of Sjogren's syndrome by keeping NFATc1 and PIM-1 in the cytoplasm in labial salivary glands (2020)
  • Author(s): Yoshiro Horai, Hideki Nakamura, Toshimasa Shimizu, Naoki Iwamoto, Atsushi Kawakami
  • Organizer: 第65回日本リウマチ学会総会・学術集会
• [Presentation] RS3PE症候群患者における既存糖尿病と治療薬についての臨床的検討 (2019)
  • Author(s): 寶來 吉朗，折口 智樹，岩永 希，徳満 純一，池岡 俊幸，厨 源平，和泉 泰衛，川上 純
  • Organizer: 第57回九州リウマチ学会
• [Presentation] 当科におけるセルトリズマブペゴル使用関節リウマチの治療効果に関する後ろ向き研究 (2018)
  • Author(s): 寶來 吉朗, 岩永 希, 和泉 泰衛, 右田 清志
  • Organizer: 第62回日本リウマチ学会総会・学術集会
• [Presentation] 高IgG4血症及び耳介組織へのIgG4陽性形質細胞浸潤を認めた抗SS-A抗体陰性/抗SS-B抗体陽性シェーグレン症候群の1例 (2018)
  • Author(s): 寶來 吉朗, 和泉 泰衛, 道辻 徹, 岩永 希, 中島 好一, 中村 英樹, 伊東 正博, 川上 純
  • Organizer: 第27回日本シェーグレン症候群学会学術集会
• [Presentation] ステロイド反応性胸水を合併したRS3PE症候群の1例 (2018)
  • Author(s): 松尾友里子, 和泉泰衛, 竹本真之輔, 寶來吉朗, 岩永希
  • Organizer: 第320回日本内科学会九州地方会
• [Book] シェーグレン症候群の診断と治療マニュアル(第4章 臨床症状 2.腺外症状 7 原発性シェーグレン症候群の筋・骨格系徴候；筋・関節病変) (2018)
  • Author(s): 日本シェーグレン症候群学会(分担執筆者 寶來 吉朗)
  • Publisher: 診断と治療社
  • ISBN: 9784787823694