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Molecular epidemiological study of syphilis in Japan

Research Project

Project/Area Number 17K16222
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionThe University of Tokyo

Principal Investigator

Adachi Eisuke  東京大学, 医科学研究所, 助教 (80725804)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords梅毒 / 分子疫学 / ゲノム解析 / MLST / 男性間性交渉 / 感染症 / 内科
Outline of Final Research Achievements

The aim of this research is to establish a method of \molecular epidemiology for syphilis which is caused by the Treponema Pallidum, T.pallidum hasbeen hindered by an inability to culture the organism continuously in vitro. we performed molecular typing of TPA, using a newly introduced MLST typing system, on samples collected in IMSUT hospital from 2016 to 2018, Out of 47 typeable samples, 13 were fully-typed at all TP0136, TP0548, and TP0705 loci. Among the fully and partially typed samples, several different allelic profiles were identified. Altogether, some novel allelic variants were found. The distribution of TPA allelic profiles identified in IMSUT hospital revealed that multiple strains have involved the syphilis endemic in Japan. e A2059G mutation was also found in half of strains identified in this study.

Academic Significance and Societal Importance of the Research Achievements

2015年度の東京都の梅毒報告数は5年前の6倍と激増し現在も増加傾向にある。一方、申請者の施設では以前より梅毒はcommonな疾患であり、実に初診のHIV患者の40%程度がTP抗体陽性で、年間10-30例程度を報告していた。日本のHIV感染者はMSM(Men who have sex with men)が多数で、heterosexualな性行為を行う集団も一定数含まれているが、梅毒の感染経路が粘膜の接触を伴う性行為に限られることを考えると集団間の伝播は少なく梅毒の分子疫学研究による成果はHIVなど他の重要な性感染症の感染防止体策に関しても効果的な介入方法を提供できる

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (10 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Cytokine Profile in Sweet's Syndrome under the Treatment of Pulmonary Toxoplasmosis Complicated with Myelodysplastic Syndrome2019

    • Author(s)
      Matsuzawa Y, Adachi E, Takahashi A, Sato H, Lim LA, Komatsu T, Koibuchi T, Nagamura-Inoue T, Tojo A, Nagayama H, Yotsuyanagi H
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 14 Pages: 2079-2083

    • DOI

      10.2169/internalmedicine.2372-18

    • NAID

      130007679530

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-07-15
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastric Syphilis in a Human Immunodeficiency Virus–Infected Patient2019

    • Author(s)
      Eisuke Adachi, Tomohiko Koibuchi, and Hiroshi Yotsuyanagi
    • Journal Title

      JMA Journal

      Volume: 2 Issue: 1 Pages: 93-94

    • DOI

      10.31662/jmaj.2018-0025

    • NAID

      130007681520

    • ISSN
      2433-328X, 2433-3298
    • Year and Date
      2019-03-04
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imported Tungiasis in a Non-endemic Country2018

    • Author(s)
      Adachi E, Miharu Y, Suzuki M, Yotsuyanagi H
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 23 Pages: 3497-3498

    • DOI

      10.2169/internalmedicine.1314-18

    • NAID

      130007539631

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-12-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] DRV/COBIへのブースター変更症例における臨床所見の変化2018

    • Author(s)
      安達 英輔, 佐藤 秀憲, 菊地 正, 古賀 道子, 堤 武也, 鯉渕 智彦, 四柳 宏
    • Journal Title

      日本エイズ学会誌

      Volume: 20 Pages: 173-178

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] GUT HOMING CD4+ T CELL COUNT IS ASSOCIATED WITH CHRONIC GASTRITIS ACTIVITY2018

    • Author(s)
      Hidenori Sato, Yasunori Ota, Yasuo Matsubara, Tadashi Kikuchi, Michiko Koga, Tomohiko Koibuchi, Takeya Tsusumi, Tetsuro Matano, Ai Kawana-Tachikawa, Hiroshi Yotsuyanagi, Eisuke Adachi.
    • Organizer
      International AIDS Conference 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] HIV感染者におけるヘリコバクターピロリと胃マイクロバイオームのクロストーク2018

    • Author(s)
      城戸康年, 安達英輔, 佐藤秀憲, 菊地正, 古賀道子, 鯉渕智彦, 堤武也, 四柳宏
    • Organizer
      第92回日本感染症学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 放射線療法により治癒したエイズ関連原発性中枢神経リンパ腫症例 第67回日本感染症学会東日本地方学術集会2018

    • Author(s)
      安達英輔, 林阿英, 佐藤秀憲, 古賀道子, 鯉渕智彦, 堤武也, 四柳宏
    • Organizer
      第67回日本感染症学会東日本地方学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] HIV感染者におけるヘリコバクターピロリと胃マイクロバイオームの相互作用2018

    • Author(s)
      桧垣朱友子, 城戸康年, 安達英輔, 松本昴, 岩崎もにか, 松原康朗, 大田泰徳, 佐藤秀憲, 菊地正, 古賀道子, 鯉渕智彦, 堤武也, 四柳宏, 山岡吉生
    • Organizer
      第32回日本エイズ学会学術集会・総会
    • Related Report
      2018 Research-status Report
  • [Presentation] HIV感染者におけるHelicobacter pylori感染2017

    • Author(s)
      安達英輔、城戸康年、佐藤秀憲、松澤幸正、菊地正、古賀道子、鯉渕智彦、四柳宏
    • Organizer
      第91回日本感染症学会総会・学術講演会、東京
    • Related Report
      2017 Research-status Report
  • [Presentation] HIV陽性者の死亡原因から見た現状 AIDS指標悪性腫瘍と非AIDS指標疾患の後方視的研究2017

    • Author(s)
      古賀道子, 菊地正, 佐藤秀憲, 安達英輔, 鯉渕智彦, 四柳宏
    • Organizer
      第31回日本エイズ学会学術集会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] EVG/cobi/FTC/TAF使用症例における臨床所見の変化2017

    • Author(s)
      安達英輔、佐藤秀憲、菊地正、古賀道子、鯉渕智彦、堤武也、四柳宏
    • Organizer
      第31回日本エイズ学会学術集会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] DRV/rtvからDRV/cobiへのブースター変更症例における臨床所見の変化2017

    • Author(s)
      安達英輔、佐藤秀憲、菊地正、古賀道子、鯉渕智彦、堤武也、四柳宏
    • Organizer
      第31回日本エイズ学会学術集会・総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 上部尿路結石に伴う閉塞性腎盂腎炎の検討2017

    • Author(s)
      松澤 幸正, 安達 英輔, 亀井 潤, 西松 寛明
    • Organizer
      第65回日本化学療法学会総会・学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] HIV感染者におけるB型急性肝炎の検討2017

    • Author(s)
      佐藤秀憲,古賀道子,菊地正,安達英輔,鯉渕智彦,堤武也,四柳宏
    • Organizer
      第66回日本感染症学会東日本地方会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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