• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the pathology and establishment of comprehensive management; Leptospirosis in Manila, Philippines

Research Project

Project/Area Number 17K16227
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionNagasaki University

Principal Investigator

Kitashoji Emi  長崎大学, 熱帯医学研究所, 客員研究員 (30772561)

Project Period (FY) 2017-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsレプトスピラ / 感染症
Outline of Final Research Achievements

Leptospirosis is a zoonotic disease caused by Leptospira spp., and exhibits various clinical manifestations ranging from mild to severe. Clear diagnosis and treatment has not been established, and severe cases have a high mortality rate.
In this study, we conducted a prospective inpatient cohort study of suspected leptospirosis patients admitted to San Lazaro Hospital, a national infectious disease hospital located in Manila, the Philippines. We collected clinical and laboratory data from severe leptospirosis patients and worked on the development of prognosis prediction methods and treatment methods. We also established new diagnostic testing techniques in San Lazaro Hospital; LigA-IgM ELISA method and the LAMP method, and strengthen diagnostic capabilities.

Academic Significance and Societal Importance of the Research Achievements

本研究では前向きコホート研究を行い、確定診断となったレプトスピラ症患者の臨床・検査データを収集することで質の高いデータセットを作成し、レプトスピラ症の重症化要因の特定を行った。血清型によるレプトスピラ患者の臨床特性の違いを明らかにすることで、今後臨床特性に応じた、効果が期待される治療法を選択することができる。予後改善効果と費用対策効果が期待でき、これらに基づいて蔓延地域における、重症レプトスピラ症患者の予後改善に貢献することを目指す。

Report

(8 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2021 2017

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results)

  • [Journal Article] Laboratory diagnostic, epidemiological, and clinical characteristics of human leptospirosis in Okinawa Prefecture, Japan, 2003-20202021

    • Author(s)
      Tetsuya Kakita, Sho Okano, Hisako Kyan Masato Miyahira, Katsuya Taira, Emi Kitashoji, Nobuo Koizumi
    • Journal Title

      PLoS Neglected Tropical Diseases

      Volume: 14;15(12) Issue: 12 Pages: e0009993-e0009993

    • DOI

      10.1371/journal.pntd.0009993

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Building prognostic models for adverse outcomes in a prospective cohort of hospitalised patients with acute leptospirosis infection in the Philippines2017

    • Author(s)
      Nathaniel Lee, Emi Kitashoji, Nobuo Koizumi, Talitha Lea V Lacuesta, Maricel R Ribo, Efren M Dimaano, Nobuo Saito, Motoi Suzuki, Koya Ariyoshi, Christopher M Parry
    • Journal Title

      Transactions of The Royal Society of Tropical Medicine and Hygiene

      Volume: 111 Issue: 12 Pages: 531-539

    • DOI

      10.1093/trstmh/try015

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2017-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi