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Role of T cell-independent production of intestinal IgA in Clostridioides difficile enteritis

Research Project

Project/Area Number 17K16231
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionTeikyo University

Principal Investigator

Yoshino Yusuke  帝京大学, 医学部, 病院准教授 (60624509)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsClostridioides difficile / トキシンB / BAFF / 免疫調整 / 病原性 / B細胞活性化因子 / B細胞活性化因子(BAFF) / クロストリジウムディフィシル / 粘膜免疫 / IgA
Outline of Final Research Achievements

This study showed that C. difficile and its components could not lead to the production of B-cell activating factors from the intestinal epithelium and monocytes/macrophages.On the other hand, toxin B, the main virulence factor of C. difficile coordinated with flagellin, one of components of flagellum from bacteria and lead the efficient production of inflammatory cytokines like CCL-20.In addition, toxin B acted on monocyte/macrophage lineage cells and increased the production of B-cell activating factor via the stimulation of interferon-gamma. This study proved that Toxin B could regulate the immune response as well as its traditional function of mucosal disruption and local inflammatory activity.

Academic Significance and Societal Importance of the Research Achievements

本研究により、Clostridioides difficileの病原因子として、最も重要と考えられているトキシンBに免疫反応を活性化する機能を有していることを新たに見出した。C. difficile感染症は院内感染の一つとして知られ、重篤になれば死に至る可能性のある疾患である一方で、再発も多く、治療にしばしば難渋する。病原性についてはいまだ不明な部分も多く、その結果コントロールが難しくなっているものと考えられている。今回、トキシンBの新たな機能を見出したが、この結果はC. difficileの病原性解明の一助になるものと考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (22 results)

All 2020 2019 2018 2017

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 4 results) Presentation (12 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Journal Article] Characteristics of pneumonia with negative chest radiography in cases confirmed by computed tomography2020

    • Author(s)
      Kitazawa Takatoshi、Yoshihara Hisanao、Seo Kazunori、Yoshino Yusuke、Ota Yasuo
    • Journal Title

      Journal of Community Hospital Internal Medicine Perspectives

      Volume: 10 Issue: 1 Pages: 19-24

    • DOI

      10.1080/20009666.2020.1711639

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral blood flow in young and middle-aged people living with HIV2019

    • Author(s)
      Yoshino Yusuke、Koga Ichiro、Kitazawa Takatoshi、Sakurai Keita、Oba Hiroshi、Matsuda Hiroshi、Furui Shigeru、Ota Yasuo
    • Journal Title

      Infectious Diseases

      Volume: 52 Issue: 2 Pages: 75

    • DOI

      10.1080/23744235.2019.1677939

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of fibroblast growth factor 23 in people living with HIV2019

    • Author(s)
      Yoshino Yusuke、Seo Kazunori、Kitazawa Takatoshi、Ota Yasuo
    • Journal Title

      Current HIV Research

      Volume: 17 Issue: 3 Pages: 198

    • DOI

      10.2174/1570162x17666190903231203

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacies of atovaquone, pentamidine, and trimethoprim/sulfamethoxazole for the prevention of Pneumocystis jirovecii pneumonia in patients with connective tissue diseases2019

    • Author(s)
      Kitazawa Takatoshi、Seo Kazunori、Yoshino Yusuke、Asako Kurumi、Kikuchi Hirotoshi、Kono Hajime、Ota Yasuo
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 25 Issue: 5 Pages: 351

    • DOI

      10.1016/j.jiac.2019.01.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prevalence of low serum free testosterone and the short-term effect of anti-retroviral therapy in male Japanese treatment-naïve HIV patients2019

    • Author(s)
      Yoshino Yusuke、Koga Ichiro、Misu Keita、Seo Kazunori、Kitazawa Takatoshi、Ota Yasuo
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 25 Issue: 4 Pages: 318

    • DOI

      10.1016/j.jiac.2018.09.007

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of bone loss and the short-term effect of anti-retroviral therapy on bone mineral density in treatment-naïve male japanese patients with HIV2019

    • Author(s)
      Yoshino Yusuke、Koga Ichiro、Misu Keita、Seo Kazunori、Kitazawa Takatoshi、Ota Yasuo
    • Journal Title

      The Open AIDS Journal

      Volume: 13 Issue: 1 Pages: 12

    • DOI

      10.2174/1874613601913010012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of osteoblast differentiation by ritonavir2018

    • Author(s)
      Wakabayashi Yoshitaka、Yoshino Yusuke、Seo Kazunori、Koga Ichiro、Kitazawa Takatoshi、Ota Yasuo
    • Journal Title

      Biomedical Reports

      Volume: 9 Issue: 6 Pages: 491

    • DOI

      10.3892/br.2018.1154

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catheter-related bloodstream infection due to Rhodotorula mucilaginosa with normal serum (1→3)-β-D-glucan level2018

    • Author(s)
      Kitazawa T.、Ishigaki S.、Seo K.、Yoshino Y.、Ota Y.
    • Journal Title

      Journal de Mycologie M?dicale

      Volume: 28 Issue: 2 Pages: 393

    • DOI

      10.1016/j.mycmed.2018.04.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short Communication: The Clinical Value of Cystatin C as a Marker of Renal Function in HIV Patients Receiving Dolutegravir2017

    • Author(s)
      Yoshino Y, Koga I, Seo K, Kitazawa T, Ota Y.
    • Journal Title

      AIDS Res Hum Retroviruses.

      Volume: 33 Issue: 11 Pages: 1080

    • DOI

      10.1089/aid.2017.0074

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical efficacy of laninamivir and peramivir in patients with seasonal influenza: a randomized clinical trial2017

    • Author(s)
      Yoshino Y, Seo K, Koga I, Kitazawa T, Ota Y.
    • Journal Title

      Infect Dis

      Volume: 49 Issue: 5 Pages: 417

    • DOI

      10.1080/23744235.2016.1242773

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] HIV 感染患者における血清 fibroblast growth factor(FGF)23 値2019

    • Author(s)
      吉野友祐, 三須恵太, 北沢貴利, 太田康男
    • Organizer
      第 93 回日本感染症学会総会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Evaluation of Clinical Course and Heath-Related Quality-of-Life Following Treatment with Oseltamivir, Laninamivir and Baloxavir Marboxil in Adult Patients with Seasonal Influenza: Prospective Observational Study2019

    • Author(s)
      Yusuke Yoshino, Ai Yamamoto, Keita Misu, Yoshitaka Wakabayashi, Takatoshi Kitazawa, Yasuo Ota
    • Organizer
      ID week 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HIV 感染症における現状の課題と最新治療アップデート2019

    • Author(s)
      吉野友祐
    • Organizer
      第68回日本感染症学会東日本地方会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] TDF/FTC から TAF/FTC へのスイッ チが骨密度及び骨代謝マーカーに及ぼす影響2019

    • Author(s)
      吉野友祐、山本 藍、三須恵太、 若林義賢、北沢貴利、太田康男
    • Organizer
      第33回エイズ学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Low-Temperature Exposure Suppresses the Production of B Cell Activating Factor Via TLR3 in BEAS-2B Cells2018

    • Author(s)
      Y. Yoshino, K. Misu, K. Seo, I. Koga, T. Kitazawa, Y. Ota
    • Organizer
      ATS 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 日本人男性 HIV 未治療患者における性腺機能 低下の状況と抗レトロウイルス薬開始後の変化について2018

    • Author(s)
      吉野 友祐, 三須 恵太, 妹尾 和憲, 古賀 一郎, 北沢 貴利, 太田 康男
    • Organizer
      日本感染症学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] Fibroblast Growth Factor 23, a Potential Risk Factor for Cardiovascular Diseases Is Associated with Abacavir/Lamivudine Use in HIV Patients.2018

    • Author(s)
      Yusuke yoshino, Keita Misu, Takatoshi Kitazawa, Yasuo Ota
    • Organizer
      ID week 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ドルテグラビルを含む抗 HIV 療法へ の変更が骨密度・骨代謝マーカーに与え る影響について2018

    • Author(s)
      吉野友祐、三須恵太、北沢貴利、太田康男
    • Organizer
      日本エイズ学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] The prevalence of bone loss and short term effect of anti-retroviral therapy on bone mineral density in male Japanese patients with HIV.2017

    • Author(s)
      Yusuke Yoshino, Keita Misu, Kazunori Seo, Ichiro Koga, Takatoshi Kitazawa, Yasuo Ota
    • Organizer
      International Congress of Chemotherapy and Infection (ICC) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The clinical value of cystatin C as a marker of renal function in HIV patients receiving dolutegravir2017

    • Author(s)
      Yusuke Yoshino, Keita Misu, Kazunori Seo, Ichiro Koga, Takatoshi Kitazawa, Yasuo Ota
    • Organizer
      ID week 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] ペラミビル及びラニナミビルの季節性インフルエンザに対する臨床効果2017

    • Author(s)
      吉野友祐、古賀一郎、妹尾和憲、北沢貴利、太田康男
    • Organizer
      第109回 日本内科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] ドルテグラビル使用 HIV 感染症患者における血清シスタチン C 測定の 有用性2017

    • Author(s)
      吉野友祐、妹尾和憲、古賀一郎、北沢貴利、太田康男
    • Organizer
      第30回日本エイズ学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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