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ENGRAFTMENT POTENTIAL OF MATERNAL ADIPOSE-DERIVED STEM CELLS FOR IN UTERO TRANSPLANTATION

Research Project

Project/Area Number 17K16311
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionShowa University

Principal Investigator

Kawashima Akihiro  昭和大学, 医学部, 講師 (10783376)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脂肪由来間葉系幹細胞 / 胎児治療 / 幹細胞治療 / ダウン症 / 脂肪組織由来幹細胞 / 胎児幹細胞治療 / 神経誘導 / 再生医療 / 脳疾患
Outline of Final Research Achievements

We hypothesised that maternal mesenchymal stem cells (MSCs) might be a better cell source of in utero transplantation for the fetal tissue than allograft MSCs. In the first part, the allograft ADSCs after in utero transplantation settled at day 28 after transplantation and also expressed TUBB3 and NeuN. In the second part of this study, we demonstrated that the maternal ADSCs induced less CD45+ cells and GFAP+ astrocytes around the transplanted cells than allogenic ADSCs. The maternal ADSCs expressed less TNFα, IL-6 and TIM1 gene expression in the fetus brain than allogenic ADSCs. Transplanting ADSCs from the mother may improve the success of in utero allogenic transplantation of ADSCs for their immune tolerance to the fetus.

Academic Significance and Societal Importance of the Research Achievements

この成果はダウン症児の高次機能障害の改善を目的とする胎児治療において、母体の間葉系幹細胞を用いることでより移植後の免疫反応を特別な加療なく抑制させることから道を開く画期的な方法であると考える。本研究成果は、出生前診断により早期治療介入が可能となった染色体疾患や遺伝性疾患をもつ胎児に対して、胎児期より進行する中枢神経系疾患における胎児治療の可能性を示すものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018 2017

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2020

    • Author(s)
      Kawashima Akihiro、Yasuhara Rika、Akino Ryosuke、Mishima Kenji、Nasu Michiko、Sekizawa Akihiko
    • Journal Title

      Heliyon

      Volume: 6 Issue: 3 Pages: 1-9

    • DOI

      10.1016/j.heliyon.2020.e03409

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytokine profiles in maternal serum are candidates for predicting an optimal timing for the delivery in early‐onset fetal growth restriction2020

    • Author(s)
      Kawashima Akihiro、Oba Tomohiro、Yasuhara Rika、Sekiya Bunbu、Sekizawa Akihiko
    • Journal Title

      Prenatal Diagnosis

      Volume: Epub Issue: 6 Pages: 728-737

    • DOI

      10.1002/pd.5679

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amplicon Sequencing-Based Noninvasive Fetal Genotyping for RHD-Positive D Antigen-Negative Alleles2019

    • Author(s)
      Takahashi Ken、Migita Ohsuke、Sasaki Aiko、Nasu Michiko、Kawashima Akihiro、Sekizawa Akihiko、Sato Taisuke、Ito Yuki、Sago Haruhiko、Okamoto Aikou、Nakabayashi Kazuhiko、Hata Kenichiro
    • Journal Title

      Clinical Chemistry

      Volume: 65 Issue: 10 Pages: 1307-1316

    • DOI

      10.1373/clinchem.2019.307074

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2019

    • Author(s)
      Akihiro Kawashima
    • Organizer
      The 72nd Annual Congress of JSOG
    • Related Report
      2019 Annual Research Report
  • [Presentation] The Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2019

    • Author(s)
      Akihiro Kawashima
    • Organizer
      International Society for Stem Cell Research 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Each negative alteration in early-onset fetal growth restriction changes the profile of maternal serum cytokines into a peculiar feature. We want to explore this further as an early warning system.2019

    • Author(s)
      Akihiro Kawashima
    • Organizer
      the 24th International Conference on Prenatal Diagnosis and Therapy.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] THE ENGRAFTMENT POTENTIAL OF MATERNAL ADIPOSE-DERIVED STEM CELLS, FOR FETAL TRANSPLANTATION2019

    • Author(s)
      Akihiro Kawashima
    • Organizer
      日本産科婦人科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Exploration of the use of adipose tissue-derived stem cells for in utero transplantation2018

    • Author(s)
      Akihiro Kawashima
    • Organizer
      International society for stem cell research
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] MOUSE ADIPOSE TISSUE-DERIVED STEM CELLS COULD BE AN IDEAL SOURCE FOR IN UTERO THERAPEUTIC REPAIR OF FETAL BRAIN DYSFUNCTION2017

    • Author(s)
      川嶋章弘
    • Organizer
      ISSCR 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 子宮内胎仔脳室内投与における脂肪組織由来幹細胞の中枢神経系への有効性2017

    • Author(s)
      川嶋章弘
    • Organizer
      第39回分子生物学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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