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Develop new therapeutic strategies for atopic dermatitis, focusing on stratum corneum pH

Research Project

Project/Area Number 17K16347
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionOita University

Principal Investigator

Sakai Takashi  大分大学, 医学部, 助教 (20624290)

Project Period (FY) 2021-03-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアトピー性皮膚炎 / 炎症性皮膚疾患 / 角層pH / トランスクリプトーム解析 / Flaky tail マウス / マイクロアレイ
Outline of Research at the Start

代表的な皮膚炎モデルマウス、かつ、角層pHの恒常性維持機能に障害があるFlaky tail mice (FTM)を用いた研究で、peroxisome proliferator-activated receptor(PPAR)シグナル経路の障害是正が、皮膚炎予防につながる可能性が示された。さらに研究代表者が所属する研究室が近年着目しているWnt/β-cateninシグナル経路の利用を含め、複数の予防法開発を目指していく。

Outline of Final Research Achievements

Atopic dermatitis (AD) is chronic dermatitis characterized by itchy and relapsed eczema. The pathogenesis of AD is not fully understood. In this study, we investigated the pathogenesis of AD with flaky tail mice (FTM), an AD model mice. It is known that FTM has a problem maintaining stratum corneum pH and develops spontaneous dermatitis with age. We found that dermatitis on FTM revealed site-specificity. And this study demonstrated that peroxisome proliferator-activated receptor signaling pathway might contribute to the pathogenesis of FTM’s dermatitis by evaluating site-specific dermatitis on FTM.

Academic Significance and Societal Importance of the Research Achievements

flaky tailマウス(FTM)は頻用されているアトピー性皮膚炎(AD)モデルマウスである。同マウスの皮膚炎をより詳細に解析した本研究は、今後、FTMを利用したAD研究のさらなる発展に貢献することが期待される。併せて、FTMは角層pH調節機能の障害を持つ。従って、本研究成果は、角層pHと皮膚炎をつなぐ病態の一部を示している可能性がある。ADにおける角層pHの役割、病態意義はまだ不明な点が多いが、本研究で得られた情報は、将来的なAD診療における角層pHの臨床応用を構築する際に、有用な基礎情報となることが期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Site-specific microarray evaluation of spontaneous dermatitis in flaky tail mice2019

    • Author(s)
      Takashi Sakai, Chinatsu Aoki, Yasuko Mori, Tomoko Yamate, Haruna Matsuda-Hirose, Yutaka Hatano
    • Journal Title

      Journal of Investigative Dermatology

      Volume: in press Issue: 12 Pages: 2554-2557.e5

    • DOI

      10.1016/j.jid.2019.04.024

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Site-specific microarray evaluation of spontaneous dermatitis in flaky tail mice2018

    • Author(s)
      Takashi Sakai, Chinatsu Aoki, Yasuko Mori, Yutaka Hatano.
    • Organizer
      International Investigative Dermatology 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2023-01-30  

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